Self-reported Food Allergy Research Articles

Prevalence of self-reported food allergy in U.S. adults: 2001, 2006, and 2010.

Epidemiologic evidence indicates that food allergies are increasing in the population. Information on a change in self-reported food allergy (srFA) in adults over time is lacking. To report the prevalence of srFA and compare differences at three time points over a decade. We analyzed srFA and reported physician-diagnosed food allergy in >4000 U.S. adults who participated in the 2010 U.S. Food and Drug Administration Food Safety Survey. Information on causative food(s), reaction severity characteristics, and various diagnostic factors was also analyzed. We compared 2010 Food Safety Survey data with 2006 and 2001 data, and highlighted relevant differences. SrFA prevalence increased significantly, to 13% in 2010 and 14.9% in 2006 compared with 9.1% in 2001 (p < 0.001). Physician diagnosed food allergy was 6.5% in 2010, which was not significantly different compared with 7.6% in 2006 and 5.3% in 2001. SrFA increased in both men and women, non-Hispanic white and black adults, 50-59 year olds, and in adults with a high school or lower education. In 2010, milk, shellfish, and fruits were the most commonly reported food allergens, similar to 2001. Also, in 2010, 15% of reactions reportedly required a hospital visit and 8.4% were treated with epinephrine. Minor differences in reaction severity characteristics were noted among the surveys. Analysis of survey results indicates that the prevalence of srFA increased among U.S. adults from 2001 to 2010 and that adults are increasingly self-reporting FAs without obtaining medical diagnosis. Improved education about food allergies is needed for this risk group.

The loss of healthy life time is similarly high for both food allergy and intolerance sufferers

Methods 314 study participants (≥18) with self-reported food allergies or intolerances were recruited in 2009 by the German Allergy and Asthma Association (DAAB). 247 completed the BELANA questionnaire four times within four-month intervals. The participants had to state whether they were unable to fulfil their daily tasks at work, at home, or at school due to problems with their food allergy or intolerance. Furthermore, they had to indicate the number of affected days.

Prevalence of self reported food allergy in US adults: 2001, 2006, and 2010.

Epidemiologic evidence indicates that food allergies are increasing in the population. Information on a change in self-reported food allergy (srFA) in adults over time is lacking. To report the prevalence of srFA and compare differences at three time points over a decade. We analyzed srFA and reported physician-diagnosed food allergy in 4000 U.S. adults who participated in the 2010 U.S. Food and Drug Administration Food Safety Survey. Information on causative food(s), reaction severity characteristics, and various diagnostic factors was also analyzed. We compared 2010 Food Safety Survey data with 2006 and 2001 data, and highlighted relevant differences. SrFA prevalence increased significantly, to 13% in 2010 and 14.9% in 2006 compared with 9.1% in 2001 (p less than 0.001). Physician diagnosed food allergy was 6.5% in 2010, which was not significantly different compared with 7.6% in 2006 and 5.3% in 2001. SrFA increased in both men and women, non-Hispanic white and black adults, 50-59 year olds, and in adults with a high school or lower education. In 2010, milk, shellfish, and fruits were the most commonly reported food allergens, similar to 2001. Also, in 2010, 15% of reactions reportedly required a hospital visit and 8.4% were treated with epinephrine. Minor differences in reaction severity characteristics were noted among the surveys. Analysis of survey results indicates that the prevalence of srFA increased among U.S. adults from 2001 to 2010 and that adults are increasingly self-reporting FAs without obtaining medical diagnosis. Improved education about food allergies is needed for this risk group.

Attitudes and preferences of consumers toward food allergy labeling practices by diagnosis of food allergies.

BACKGROUND/OBJECTIVESThe objective of this study was to investigate food allergens and prevalence rates of food allergies, followed by comparison of consumer attitudes and preferences regarding food allergy labeling by diagnosis of food allergies.SUBJECTS/METHODSA total of 543 individuals living in Seoul and Gyeonggi area participated in the survey from October 15 to 22 in 2013.RESULTSThe results show that the prevalence of doctor-diagnosed food allergies was 17.5%, whereas 6.4% of respondents self-reported food allergies. The most common allergens of doctor-diagnosed and self-reported food allergy respondents were peaches (30.3%) and eggs (33.3%), respectively, followed by peanuts, cow's milk, and crab. Regarding consumer attitudes toward food labeling, checking food allergens as an item was only significantly different between allergic and non-allergic respondents among all five items (P < 0.001). All respondents reported that all six items (bold font, font color, box frame, warning statement, front label, and addition of potential allergens) were necessary for an improved food allergen labeling system. PLSR analysis determined that the doctor-diagnosed group and checking of food allergens were positively correlated, whereas the non-allergy group was more concerned with checking product brands.CONCLUSIONSAn effective food labeling system is very important for health protection of allergic consumers. Additionally, government agencies must develop policies regarding prevalence of food allergies in Korea. Based on this information, the food industry and government agencies should provide clear and accurate food labeling practices for consumers.

Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

BackgroundIt is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.ObjectiveTo discover if FA in a random sample from the Dutch community is comparable to that of outpatients.MethodsThis study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.ResultsIn the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.ConclusionIn the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

I can’t eat that: The sociology behind the rise in food allergies and intolerances

This article focuses on the social and cultural aspects of the unprecedented and unparalleled proliferation of food-related allergies and intolerances. It thus aims to contribute to filling the theoretical lacunae in the current sociological approach to this fairly recent phenomenon. The article’s framework is divided into four segments. First, the rise in food allergies is placed within the field of the social history and medicalization of allergies, and seeks to understand the phenomenon in the context of the industrialized modern world. The following section discusses how and why lay experts are increasingly dominating the food allergy-related discourse. Drawing on recent empirical data, it is further shown how food allergies rise along with a population’s affluence and education. Third, the idiosyncrasies of food allergies and intolerances are addressed with respect to food consumption and its changing social implications. It is argued that individualization places less pressure on individuals to conform to broader social norms of food refusal, which offers the sufferers with a newly acquired sense of control over a random, scientified, and confounding food availability and provides a medium to covertly convey their educational and socioeconomic background. Lastly, the health belief model is applied in order to suggest a further potential explanation for the current increase in self-reported food allergies and intolerances.

Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET)

Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET)

Access to health care and food in children with food allergy

Access to health care and food in children with food allergy

Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States

BackgroundThe prevalence of food allergy is thought to be increasing, but data from the United States have not been systematically synthesized. ObjectiveTo summarize the data on prevalence of food allergy in the US pediatric population and to estimate the effects of time, race/ethnicity, and method of assessing food allergy on the estimated prevalence. MethodsEmbase, MEDLINE, bibliographies of identified reports, and data from publically available data sets were searched. Studies were limited to those in English with data from the general pediatric US population. Study synthesis was performed by meta-analysis and meta-regression to estimate the effect of study- and participant-level covariates. Meta-regression was limited to nationally representative surveys conducted by the Centers for Disease Control and Prevention. ResultsA total of 10,090 publications were identified, from which 27 different survey administrations, representing 452,237 children, were identified, covering the period of 1988 to 2011. Because of heterogeneity among surveys in the estimated food allergy prevalence, a summary estimate of food allergy prevalence was not possible. Meta-regression was performed using 20 of these surveys. Temporal trends were pronounced, with an estimated increased prevalence of self-reported food allergy of 1.2 percentage points per decade (95% confidence interval [CI], 0.7-1.6). The increase per decade varied by race/ethnicity: 2.1% among non-Hispanic blacks (95% CI, 1.5%-2.7%), 1.2% among Hispanics (95% CI, 0.7%-1.7%), and 1.0% among non-Hispanic whites (95% CI, 0.4%-1.6%). ConclusionSelf-report of food allergy among US children has sharply increased in the past 2 decades. The increase has been greatest among non-Hispanic black children, a disparity that needs to be investigated.

Food allergy competencies of dietitians in the United Kingdom, Australia and United States of America.

BackgroundA knowledgeable and competent dietitian is an integral part of the food allergy multidisciplinary team, contributing to effective diagnosis and management of food allergic disorders. Little is currently known about the food allergy training needs and preferences of dietitians. The purpose of this paper is to measure and compare self-reported food allergy competencies of dietitians based in the UK, Australia and USA.MethodsA survey of USA-based paediatric dietitians was developed to measure self-reported proficiency and educational needs in the area of food allergy. The survey was modified slightly and circulated online to paediatric and adult dietitians in the UK and Australia. Descriptive statistics and Pearson correlations are presented.ResultsA total of 797 dietitians completed the questionnaire. Competency in “developing food challenge protocols” and “managing feeding problems” were rated the poorest overall across all three settings. A higher level of competency was significantly positively associated with length of practice as a dietitian, percentage of caseload composed of patients with food allergy and training in food allergy. The most popular topics for further training were food additives, pharmacological reactions and oral allergy syndrome.ConclusionsThere is a need amongst dietitians to increase their knowledge in different aspects of food allergy diagnosis and management, specifically the areas of developing food challenge protocols and management of feeding problems. This study provides valuable information for designing targeted food allergy education for dietitians.Electronic supplementary materialThe online version of this article (doi:10.1186/2045-7022-4-37) contains supplementary material, which is available to authorized users.

Prevalence of Food Allergy and the Sensitization Rates of Food Allergens in School-Aged Children in Jeju

Objectives : This study is to survey school-aged children's prevalence of food allergy and to investigate sensitization rates to common food allergens. Methods : The self-administered questionnaire survey and skin prick tests with 12 food allergens were applied to school children in Jeju, Korea. From 3 elementary schools, 1,189 children were enrolled with informed consent. Results : The lifetime prevalence of self-reported food allergy were 10.5%. The period prevalence of self-reported food allergy(last 12 months), the lifetime prevalence of clinician-diagnosed food allergy and the period prevalence of clinician-treated food allergy(last 12 months) were 4.8%, 5.8% and 2.6%, respectively. The sensitization rate to one or more food allergens was 3.7%. Male(4.8%) showed more sensitized than female (2.5%)(p=0.043). Shrimps(1.1%), egg white(0.6%), mussels(0.5%), yolk(0.4%) and milk(0.4%) were commonly sensitized food allergens. The commonly associated allergens in the lifetime prevalence of food allergy include egg white, yolk, tuna, chicken and soybeans. The multivariate analysis revealed that the allergens most significantly related with the lifetime prevalence of food allergy were eggs, showing the risk of food allergy was 10.53 times higher in the cases with sensitization to egg. Conclusion : Compared to those in other regions, the school-aged children in Jeju show no difference in the prevalence of food allergy, but, with a gradual increase in frequency. Among the food allergens, egg is one of the most commonly sensitizing allergen as well as cause of food allergy. Serial epidemiological investigations and customized educational programs concerning food allergy are necessary at school.

The epidemiology of food allergy in Europe: a systematic review and meta‐analysis

Food allergy (FA) is an important atopic disease although its precise burden is unclear. This systematic review aimed to provide recent, up-to-date data on the incidence, prevalence, time trends, and risk and prognostic factors for FA in Europe. We searched four electronic databases, covering studies published from 1 January 2000 to 30 September 2012. Two independent reviewers appraised the studies and qualified the risk of bias using the Critical Appraisal Skills Programme tool. Seventy-five eligible articles (comprising 56 primary studies) were included in a narrative synthesis, and 30 studies in a random-effects meta-analysis. Most of the studies were graded as at moderate risk of bias. The pooled lifetime and point prevalence of self-reported FA were 17.3% (95% CI: 17.0-17.6) and 5.9% (95% CI: 5.7-6.1), respectively. The point prevalence of sensitization to ≥1 food as assessed by specific IgE was 10.1% (95% CI: 9.4-10.8) and skin prick test 2.7% (95% CI: 2.4-3.0), food challenge positivity 0.9% (95% CI: 0.8-1.1). While the incidence of FA appeared stable over time, there was some evidence that the prevalence may be increasing. There were no consistent risk or prognostic factors for the development or resolution of FA identified, but sex, age, country of residence, familial atopic history, and the presence of other allergic diseases seem to be important. Food allergy is a significant clinical problem in Europe. The evidence base in this area would benefit from additional studies using standardized, rigorous methodology; data are particularly required from Eastern and Southern Europe.

Prevalence and classification of rhinitis in preschool children in Portugal: a nationwide study

Information on rhinitis epidemiology in preschool children is scarce. To estimate, in children with 3-5years of age, current rhinitis prevalence, to describe rhinitis symptoms and associated sociodemographic characteristics, and to report allergic rhinitis and its impact on asthma (ARIA) classification. Cross-sectional, nationwide, population-based study including children aged 3-5years. A multistep selection strategy was used to obtain a representative sample. Data were collected at kindergartens and parish centers by face-to-face interview to caregivers, using an adapted ISAAC questionnaire. 'Current rhinitis' (CR) was defined as the presence of ≥1 rhinitis symptom (repeated sneezing and/or itchy nose, blocked nose for >1h, or runny nose without having a cold/flu) in the last year. Rhinitis lasting ≥4days/week and ≥4 consecutive weeks was classified as persistent. Moderate-severe disease interfered 'a moderate amount' or 'a lot' in daily activities. Five thousand and eighteen children were included. CR prevalence was 43.4% [95% CI (42.0-44.8%); n=2179] and that of physician-diagnosed rhinitis was 11.7% [95% CI (10.8-12.6%); n=588]. Of children with CR, 67% reported blocked nose, 48% rhinorrhea, and 46% sneezing/itchy nose. Considering ARIA classification, 30% of the population had mild intermittent, 3% mild persistent, 7% moderate-severe intermittent, and 3% moderate-severe persistent rhinitis. Children with CR had more current wheezing, physician-diagnosed asthma, self-reported food allergy, and family history of allergic disease. These characteristics were also associated with persistent and moderate-severe rhinitis. This is the first nationwide population-based study reporting rhinitis prevalence and ARIA classification in preschool children. In this age-group, rhinitis is frequent and underdiagnosed. About 25% children with rhinitis presented moderate-severe disease.

Prevalence of self-reported food allergy in the National Health and Nutrition Examination Survey (NHANES) 2007-2010

Food allergy is a common condition, with widely varying estimates of prevalence worldwide and within the United States. The National Health and Nutrition Examination Survey (NHANES) is a periodic survey conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention that examines a nationally representative sample of approximately 5000 subjects each year. Further description of NHANES methodologies can be found in this article's Online Repository at www.jacionline.org.

The prevalence of food allergy among Aboriginal people in Canada

Background Data suggest that Aboriginal people may experience lower rates of food allergy compared with the general population. However, there have not been any population-based studies to estimate the prevalence of food allergy among Aboriginal People in Canada. Given this gap in the literature, the goal of this study is to estimate the prevalence of food allergy among Canadian Aboriginal people (First Nations, Metis or Inuit), and to compare these estimates with the general population. Methods We performed a nationwide, cross-sectional telephone survey of all Canadian provinces and territories. Census Canada 2006 data were used to identify postal codes containing a high proportion of Aboriginal people and telephone numbers were randomly selected. The household respondent was queried on whether any household member had a food allergy. Prevalence estimates and 95% Confidence Intervals (CI) were calculated for the nine most common food allergens (peanut, tree nut, fish, shellfish, sesame, milk, egg, wheat, and soy) and for all foods, among individuals reporting Aboriginal status and for the general population. Results Out of 12,747 households contacted, 6,403 responded (50.2% response rate, representing 15,043 individuals), of which 2,264 reported Aboriginal status (15.1% of individuals). All allergies except peanut and fish are more common among the general population than Aboriginal people, although the difference is only significant for tree nut [1.22% (95% CI, 1.00%, 1.44%) vs. 0.57% (95% CI, 0.31%, 0.98%)], shellfish [1.60% (95% CI, 1.35%, 1.86%) vs. 0.93% (95% CI, 0.58%, 1.41%)], milk [1.97% (95% CI, 1.64%, 2.29%) vs. 0.49% (95% CI, 0.24%, 0.87%)], wheat [0.77% (95% CI, 0.57%, 0.96%) vs. 0.13% (95% CI, 0.03%, 0.39%)] and all foods [8.07% (95% CI, 7.47%, 8.67%) vs. 4.90% (95% CI, 4.05%, 5.87%)]. Conclusion Our study suggests that the self-reported prevalence of several food allergies is lower in the Aboriginal population as compared with a representative sample of the general Canadian population. The lower prevalence of self-reported food allergy in the Aboriginal population may be attributable to several factors: genetics, differences in dietary habits and the environment, and inequities in access to health care, education and information about food allergy. These findings support a need for better education and access to health care services for Aboriginal communities, and future studies to explore the role of genetics, diet and environment in the development of food allergy.

Association between Loss-of-Function Mutations in the Filaggrin Gene and Self-Reported Food Allergy and Alcohol Sensitivity

Background: Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. Objective: We investigated the association of FLG mutations with self-reported food allergy, symptoms of oral allergy syndrome (OAS), and alcohol sensitivity. Methods: A total of 3,471 adults from the general population participated in a health examination. Information on food allergies, OAS and alcohol sensitivity was obtained by questionnaire. FLG mutation carriers were defined as having at least one null mutation allele of R501X or 2282del4. Primary lactose intolerance (PLI) was defined as the C/C genotype of the rs4988235 polymorphism. Results: FLG mutations were associated with a higher risk of self-reported allergy to eggs (OR 3.22 and 95% CI 1.46-7.11), milk (OR 2.10 and 95% CI 1.12-3.92), fish (OR 4.54 and 95% CI 1.88-10.96) and wheat (OR 3.59 and 95% CI 1.61-8.02), but not with symptoms of OAS (OR 1.05 and 95% CI 0.73-1.51). Serum-specific IgE was measured in a subsample and confirmed the association between FLG and IgE to milk. A significant gene-by-gene interaction between FLG and PLI was observed in relation to self-reported allergy to milk. Furthermore, FLG mutations were associated with a higher risk of alcohol sensitivity. Conclusions: We found that loss-of-function mutations in the FLG gene were significantly associated with self-reported food allergy and alcohol sensitivity, but not with OAS. These findings, if confirmed, support the idea that skin barrier functions may be involved in the pathogenesis of food allergy.

Health sector costs of self-reported food allergy in Europe: a patient-based cost of illness study

Food allergy is a recognized health problem, but little has been reported on its cost for health services. The EuroPrevall project was a European study investigating the patterns, prevalence and socio-economic cost of food allergy. To investigate the health service cost for food-allergic Europeans and the relationship between severity and cost of illness. Participants recruited through EuroPrevall studies in a case-control study in four countries, and cases only in five countries, completed a validated economics questionnaire. Individuals with possible food allergy were identified by clinical history, and those with food-specific immunoglobulin E were defined as having probable allergy. Data on resource use were used to estimate total health care costs of illness. Mean costs were compared in the case-control cohorts. Regression analysis was conducted on cases from all 9 countries to assess impact of country, severity and age group. Food-allergic individuals had higher health care costs than controls. The mean annual cost of health care was international dollars (I$)2016 for food-allergic adults and I$1089 for controls, a difference of I$927 (95% confidence interval I$324-I$1530). A similar result was found for adults in each country, and for children, and was not sensitive to baseline demographic differences. Cost was significantly related to severity of illness in cases in nine countries. Food allergy is associated with higher health care costs. Severity of allergic symptoms is a key explanatory factor.

Relating microarray component testing and reported food allergy and food-triggered atopic dermatitis: a real-world analysis

BackgroundHigh epitope diversity has been associated with increased IgE-mediated food allergy severity. ObjectiveTo characterize associations between results from an automated microarray system and self-reported food allergy and food-triggered atopic dermatitis (AD). MethodsFamilies with food allergic children were identified from a Jewish community in Lakewood, New Jersey, with immediate family members without food allergy or food-triggered AD serving as controls for the identified children. Sets of microarray components analyzed were to milk (Bos d 4, Bos d 5, Bos d 8, Bos d lactoferrin), egg (Gal d 1, Gal d 2, Gal d 3, Gal d 5), and peanut (Ara h 1, Ara h 2, Ara h 3, Ara h 6). ResultsSeventy-three patients from 23 families were recruited. Culprit foods included milk (n = 20), egg (n = 10), and peanut (n = 6) for food allergy and milk (n = 10) and egg (n = 7) for food-triggered AD. Odds of having had a self-reported related food allergy or food-triggered AD reaction significantly increased with a higher number of detectable microarray components to that food. Ara h 1, Ara h 2, and Ara h 6 were individually associated with reported peanut allergy, and Bos d 4 was individually associated with reported milk allergy. The number of egg components significantly increased the odds of having related food-triggered AD. ConclusionHigh diversity of food allergen components relates well to self-reported history of food allergy and food-associated AD.

Current status of managing food allergies in schools in Seoul, Korea

Recently the need to manage food allergies in schools has been growing. This study aimed to examine the current status of managing food allergies in schools in Seoul, Korea. A questionnaire survey was conducted in cooperation with the School Dietician Association during April 2009. Among the participating 154 schools, a total of 109 (71%) were determining students' food allergy status through parental surveys based on self-reported food allergies. A total of 72 (47%) had experienced student visits to a school health room due to food allergies within one year before the survey. Over 80 percent of the schools relied on self-care only without any school-wide measures for food allergies in place. Among the 890 menu items most frequently served in school lunch programs, a total of 664 (75%) were found to contain more than one food allergen. It is highly suggested that preventive plans and treatment measures should be established to manage food allergies in schools.

Overall prevalence of self-reported food allergy in Canada

Overall prevalence of self-reported food allergy in Canada