Selective Extraction Research Articles

Electrochemical insights into the direct dissolution of impure sphalerites and their partial oxidation in an acidic environment

This study examined the electrodissolution mechanism of five impure sphalerite samples, which differ significantly in purity levels, along with their partially oxidized counterparts in a 0.5 M H2SO4. Partially oxidized samples were prepared through an incomplete leaching of sphalerite using H2SO4 with Fe2(SO4)3.H2O as an oxidizing agent. The original sphalerite samples and the partially oxidized samples were referred to as SP and POS samples, respectively. Analyses using XRD, SEM, Raman spectroscopy, and electrochemical techniques suggested presence of elemental sulfur and a metal-deficient layer on the surface of the POS samples. Cyclic voltammetry revealed that the sample with the highest iron content exhibited the highest electrochemical response, while the sphalerite with the highest lead concentration had the lowest activity. Electrochemical impedance spectroscopy (EIS) studies showed that impedance values were higher in the POS samples compared to the PS samples, indicating a correlation within the passivation phenomenon. In conclusion, these findings suggested that the sphalerite dissolution process is primarily controlled by charge transfer and kinetic polarization. This understanding can lead to the development of more selective and sustainable extraction methods and improving the overall economic viability of zinc hydrometallurgical operations.

Comparison of 12- to 24-Hour Versus 72-Hour Intravenous Terlipressin in Patients With Acute Esophageal Variceal Bleeding: A Systematic Review and Meta-analysis.

Objective: To compare the efficacy and safety of 12-24 hours versus 72 hours of intravenous terlipressin therapy in patients with acute esophageal variceal bleeding (AVB). Data sources: A systematic search was conducted using PubMed, Scopus, Cochrane Library, Google Scholar, Web of Science, VHL, and ClinicalTrials.gov for studies published up to February 24, 2024. The search terms included "terlipressin," "variceal bleeding," "short-course," and "72-hour treatment." Study selection and data extraction: Randomized controlled trials (RCTs) comparing 12 to 24 hours with 72 hours of terlipressin therapy in patients with AVB were included. Studies not meeting these criteria or focusing on unrelated outcomes were excluded. Two authors conducted data extraction and bias assessment independently, with discrepancies resolved by a third reviewer. Baseline characteristics and outcomes (rebleeding and mortality within 5 days) were recorded. Results: Four RCTs with 469 patients were included in the analysis. There were no significant differences observed in 5-day rebleeding rates (OR = 0.943; 95% CI [0.384, 2.317]; P = 0.898) or mortality rates (OR = 0.386; 95% CI [0.066, 2.260]; P = 0.291) between terlipressin treatment durations of 12 to 24 hours and 72 hours within the first 5 days posttreatment. In addition, no heterogeneity was found in both variables (P > 0.1). Conclusion: This meta-analysis indicates that there is no significant difference in rebleeding rates or mortality between 12 to 24 hours and 72 hours of terlipressin therapy for AVB within 5 days posttreatment. Shorter treatment durations may offer advantages in terms of resource utilization and adverse event risk but require further validation through studies involving larger patient populations.

Efficient and Selective Extraction of Prenylated Flavonoids from Sophora flavescens Using Ultrasound-Assisted Hydrophobic Ionic Liquid and Characterization of Extraction Mechanism

Efficient and Selective Extraction of Prenylated Flavonoids from Sophora flavescens Using Ultrasound-Assisted Hydrophobic Ionic Liquid and Characterization of Extraction Mechanism

Recovery of rare earths from end-of-life NdFeB permanent magnets from wind turbines.

This work aims to recover rare earths from wind turbines NdFeB magnets through pyrometallurgical and hydrometallurgical techniques. First, a NdFeB hydride powder is obtained by decrepitation with hydrogen. Subsequently, this powder was subjected to a chlorination roasting process and successive leaching with water to bring the metals into solution. This was followed by a liquid-liquid extraction to remove the iron and purify the rare earth solution. For this purpose, Aliquat 336 diluted in Solvesso was selected as the iron selective extraction agent. As a single extraction was not enough for complete iron removal, a second Fe extraction step was carried out. This second extraction step was performed using the restored organic phase. This restoration was achieved by treating the organic phase with Na2SO3 and then washing it with a 3M HCl solution. In this way, the process was achieved more sustainably. Finally, the rare earths contained in the final solution were precipitated using oxalic acid to obtain mixed rare earth oxalates.

P0728 Interventions for ocular extraintestinal manifestations in inflammatory bowel disease: an umbrella review of systematic reviews

Abstract Background A significant proportion of patients with inflammatory bowel disease (IBD) develop extraintestinal manifestations (EIM). Ocular involvement occurs in an estimated 12–25% of ulcerative colitis cases and 25–50% of Crohn’s disease cases, making it the third most common EIM after rheumatological and dermatological manifestations. There is limited information on treatment options for ocular EIM. To address this gap, we reviewed all systematic reviews (SRs) evaluating drug interventions for ocular EIM. Methods We searched three databases (MEDLINE, Embase, and the Cochrane Database of Systematic Reviews) from inception to May 2024 to identify SRs addressing therapeutic interventions for ocular EIM. The exclusion criteria ruled out studies that were not systematic reviews, did not focus on patients with IBD, or were unrelated to ocular interventions. Screening, selection, and data extraction were performed independently by two authors, with a third author consulted when necessary. The quality of SRs was assessed using the AMSTAR-2 tool. Results Of 1,436 studies, six met the inclusion criteria. The ocular EIMs most commonly reported included uveitis, iritis, scleritis, and episcleritis. The number of studies reporting ocular EIM within each SR varied from two (Guillo, 2021) to 22 (Peyrin-Biroulet, 2017). Therapeutic interventions differed: two SRs evaluated vedolizumab (Zheng, 2024; Chateau, 2019), one focused on ustekinumab (Guillo, 2021), while the others assessed different advanced therapies. Quality assessment using AMSTAR-2 rated the reviews from high to low confidence, with most achieving moderate confidence due to some non-critical weaknesses. The incidence of new ocular EIM after treatment was 1% for both vedolizumab and ustekinumab in two SRs. For existing EIM, ocular symptoms improved in 55–59% of cases with ustekinumab (data from two SRs). However, there was no consistent evidence supporting vedolizumab for treating established ocular EIM. Anti-tumor necrosis factor (TNF) drugs were evaluated in two SRs, showing benefits for most patients with ocular manifestations without notable differences in the effectiveness among the different anti-TNF agents. No SRs focused on the risk of new ocular EIM after starting anti-TNF therapy. Conclusion Infliximab, adalimumab, certolizumab and ustekinumab appear effective for ocular EIM. There is no strong evidence that vedolizumab is effective for treating existing ocular EIM, though it may reduce the occurrence of new EIM. Further research with clear definitions and systematic assessments of ocular manifestations is needed. A multidisciplinary approach remains crucial. References Licona Vera E, Betancur Vasquez C, Peinado Acevedo JS, Rivera Bustamante T, Martinez Redondo JM. Ocular Manifestations of Inflammatory Bowel Disease. Cureus. 2023;15(6):e40299

P0989 Interventions for rheumatological extraintestinal manifestations in Inflammatory Bowel Disease: an umbrella review of systematic reviews

Abstract Background Inflammatory Bowel Disease (IBD) is associated with extraintestinal manifestations (EIMs), commonly affecting the joints, eyes, skin, and liver, and influences treatment selection. We aimed to synthesize evidence from systematic reviews (SRs) with or without meta-analyses on the efficacy of therapeutic options for rheumatological EIMs to better clarify their positioning in the management of IBD Methods We searched MEDLINE, Embase, and the Cochrane Database of Systematic inception to May 31 2024 to identify SRs addressing therapeutic interventions for rheumatological EIMs. The exclusion criteria ruled out studies that were not SRs, did not focus on patients with IBD patients, or were unrelated to articular interventions. Screening, selection, and data extraction were performed independently by two authors, with a third author consulted when necessary. Reporting was aligned with PRISMA standards. The quality of SRs was assessed using the AMSTAR-2 tool Results We screened 1,436 references and included 10 SRs (2 with meta-analyses) in our analysis. The rheumatological EIMs most commonly reported included arthralgia, peripheral arthropathy, axial arthropathy, spondyloarthritis, and sacroiliitis. Therapeutic interventions included in the SRs were anti-TNF agents, methotrexate (MTX), ustekinumab, (UST) vedolizumab (VDZ), and JAK inhibitors. Treatment efficacy was mainly reported through symptom reduction rates. Quality of the SRs rated from high to very low confidence, with most achieving moderate confidence due to some non-critical weaknesses. In four SRs anti-TNF therapy showed high response rates for both axial (range 59.1% to 61.8% in a SR) and peripheral spondyloarthritis (range 73.4% to 81.2% in a SR). One SR reported MTX as effective for peripheral enteropathic arthritis. Data on VDZ, UST, and JAK inhibitors were more controversial. One SR reported that UST was effective for arthralgia and psoriatic arthritis. A more recent meta-analysis showed that the improvement of pre-existing joint manifestations was greater in UST-treated patients compared to VDZ-treated patients (54% vs 42%). For tofacitinib, no change in peripheral arthritis was reported by two SRs. Four SRs evaluated treatment-induced rheumatological EIMs, revealing heterogeneous results, particularly with VDZ. However, data from a recent SRs suggest similar rates of new-onset rheumatological EIMs with VDZ and UST (9% vs. 6%) Conclusion Anti-TNF therapy appears to be effective in managing both peripheral and axial spondyloarthritis. Given the lack of consistent data on new advanced therapies, prospective studies designed to assess the impact of other advances therapeutics on rheumatological EIMs ,with rigorous endpoint assessment, are needed

Synthesis of a fluorophilic magnetic microporous organic network for selective enrichment of fipronil and ethiprole in milk and egg samples.

Considering the widespreadly use, large consumption, and serious environmental and health threats of phenylpyrazole insecticides (PPIs), development of a selective and sensitive method for accurate detection of their residuals in food samples is of great significance and challenging. Herein, depending on the hydrophobic and F-containing characteristics of PPIs, a novel fluorinated magnetic microporous organic network (FMMON) was designed and prepared for efficient and selective magnetic solid-phase extraction (MSPE) of two typical PPIs (fipronil and ethiprole) from milk and egg samples before the HPLC-UV determination. FMMON owned large specific surface area, multiple interaction sites, excellent magnetic separation performance and stability and exhibited good extraction and selectivity for fipronil and ethiprole through the specific F-F, hydrogen bonding, hydrophobic, and π-π interactions. Under optimal extraction conditions, the established FMMON-MSPE-HPLC-UV method provided wide linear ranges (0.1-1000 µg L-1), low limits of detection (0.03-0.05 µg L-1), large enrichment factors (96.2-99.7), low adsorbent consumption (4 mg), and short extraction time (6 min) for fipronil and ethiprole. This work revealed the bright future of fluorinated MONs in sample pretreatment of fluorinated contaminants in complex substrates.

Selective gold extraction from e-waste leachate via sulfur-redox mechanisms using sulfhydryl-functionalized MOFs.

Urban mining of precious metals from electronic waste (e-waste) offers a dual advantage by addressing solid waste management challenges and supplying high-value metals for diverse applications. However, traditional extraction methods generally suffer from poor selectivity and limited capacity in complex acidic leachate. Herein, we present a sulfhydryl-functionalized zirconium-based metal-organic framework (Zr-MSA-AA) as a recyclable and highly selective adsorbent for efficient gold recovery. Specifically, the Zr-MSA-AA exhibits high recovery capacity (1021 mg g-1), remarkable pH-universal, and superb selectivity (Kd of 2.2 × 107 mL g-1) for gold ions across wide pH range and competitive conditions. Comprehensive mechanistic investigations highlight the pivotal role of sulfhydryl groups in selectively capturing gold ions. The redox-transformation of sulfhydryl and sulfonic acid groups mediated the reduction of Au(III) to Au(0) through the nucleation of chlorine-stabilized gold clusters. This unique mechanism, driven by the redox activity of designed sulfhydryl sites, not only mitigates interference from competing cations but also facilitates rapid adsorption kinetics (kf of 1.17 × 10-7 m s-1) for gold ions, surpassing the performance of previous adsorbents. Consequently, Zr-MSA-AA demonstrates exceptional practical applicability, achieving high-purity gold recovery (23.8 Karat) from real e-waste leachate through straightforward physical separation methods. This study introduces an alternative practical strategy for utilizing sulfur's redox activity in adsorbent design, advancing the sustainable recycling of non-renewable metal resources while contributing to environmental conservation.

Functionalized 2D multilayered MXene for selective and continuous recovery of rare earth elements from real wastewater matrix.

Rare earth elements (REEs) are the "fuel" for high-tech industry, yet their selective recovery from complex waste matrices is challenging. Herein, we designed a 2D multilayered MXene Ti3C2Tx adsorbent for selective extraction of REEs in a broad pH range. By establishing strong Lewis acid-base interactions, extraction capacities of Ti3C2Tx to Eu(III) and Ho(III) reached 892.8 and 649.2 mg/g, respectively, even at pH 2.0. Following the Valence Matching Principle, the Ti3C2Tx adsorbent also demonstrated high selectivity for recovery of various REEs from real REEs processing wastewater and actual sludge from magnet manufacturing industry. To demonstrate the practical feasibility, a layer-stacked membrane of Ti3C2Tx supported on polyethersulfone substrate was fabricated for continuous recovery of REEs and exhibited excellent removal of Eu(III) (99.1 % at pH 5.0), showcasing its potential for large-scale applications. DFT calculations and material characterization demonstrated that chemisorption between Lewis acid (REEs cations) and Lewis base (F and O) sites is the main adsorption process involved in the uptake of Eu(III) and Ho(III). Finally, both the Ti3C2Tx adsorbent and membrane were successfully regenerated and reused via simple acid wash. Overall, the results demonstrate the Ti3C2Tx-based recovery as a promising path for sustainable harvesting of REEs.

Green and selective supercritical fluid extraction of essential oil and cannabidiol from Cannabis sativa L.

Green and selective supercritical fluid extraction of essential oil and cannabidiol from <scp><i>Cannabis sativa</i></scp> L.

Solid-liquid Extraction of Lithium Chloride with a Simple and Flexible Heteroditopic Receptor

Abstract The global demand for lithium has surged in recent years due to its wide applications in industry and medicine. We have achieved selective solid-liquid extraction of LiCl using a heteroditopic receptor with an ether linker as a cation recognition site and two urea functionalities as cooperative anion recognition sites. The receptor exhibits high selectivity for LiCl from 1H NMR spectra by complexation in CD3CN and CDCl3. The solid-liquid extraction, followed by stripping to neutral aqueous phase using with the receptor revealed recovery of LiCl about 90% by ion chromatography and ICP-MS analyses, with a slight competition with MgCl2. LiCl was also recovered from the artificially prepared salt mixture and natural one from the Salar de Uyuni by the solid-liquid extraction with less competitive recovery of MgCl2.

Electro-driven direct lithium extraction from geothermal brines to generate battery-grade lithium hydroxide

As Li-ion batteries are increasingly being deployed in electric vehicles and grid-level energy storage, the demand for Li is growing rapidly. Extracting lithium from alternative aqueous sources such as geothermal brines plays an important role in meeting this demand. Electrochemical intercalation emerges as a promising Li extraction technology due to its ability to offer high selectivity for Li and its avoidance of harsh chemical regenerants. In this work, we design an economically feasible electrochemical process that achieves selective lithium extraction from Salton Sea geothermal brine and purification of lithium chloride using intercalation materials, and conversion to battery grade (>99.5% purity) lithium hydroxide by bipolar membrane electrodialysis. We conduct techno-economic assessments using a parametric model and estimated the levelized cost of LiOH•H2O as 4.6 USD/kg at an electrode lifespan of 0.5 years. The results demonstrate the potential of our technology for electro-driven, chemical-free lithium extraction from alternative sources.

Selective extraction process of scandium from nickel laterite waste through hydrometallurgy.

Scandium (Sc) extraction from iron and aluminum waste is a promising technique for the recycling and valorization of laterite nickel ore waste. Iron and aluminum waste is one source of scandium during preparation of nickel and cobalt hydroxide by wet smelting of laterite nickel ore. The content of Sc is notably higher than that of the raw materials, as the element is enriched in the iron and aluminum waste. As the main element in the waste samples, Al exhibits significant interference in the selective separation of Sc. In this work, taking the production line for laterite nickel ore wet leaching as the research object, the trend and distribution of trace Sc were systematically analyzed. A series of leaching experiments was conducted under varied conditions of leaching pH (2.6-3.5), leaching time (0.5-2.0 h), volume of evaporated concentrated solution (0.2-1.0 L), mass of waste added (200-800 g), reaction temperature (240-260 °C), reaction time (0.5-1.5 h), H2SO4 addition amount (50-300 mL L-1) and (NH4)2SO4 addition amount (150-350 kg m-3). Experimental results revealed that the optimum leaching conditions were observed at a pH value of 3.0 and a leaching duration of 1 h. The optimum condition for evaporation and concentration was at 0.35 L, while the optimum conditions for impurity removal were at a waste mass of 300 g, a reaction temperature of 255 °C and a reaction time of 1 h. Under these optimum conditions, scandium content was approximately 14.67%. The product was identified as a complex salt of Sc through XRD, which could be converted to high-purity Sc2O3 after roasting.

Application of Response Surface Methodology for Selective Extraction of Lithium Using a Hydrophobic Deep Eutectic Solvent

Application of Response Surface Methodology for Selective Extraction of Lithium Using a Hydrophobic Deep Eutectic Solvent

Naso-intestinal versus gastric tube for enteral nutrition in patients undergoing mechanical ventilation: a systematic review and meta-analysis

BackgroundA systematic appraisal of the comparative efficacy and safety profiles of naso-intestinal tube versus gastric tube feeding in the context of enteral nutrition for mechanically ventilated (MV) patients is imperative. Such an evaluation is essential to inform clinical practice, ensuring that the chosen method of nutritional support is both optimal and safe for this patient population.MethodsWe executed an exhaustive search across PubMed et al. databases to identify randomized controlled trials (RCTs) that scrutinize the role of naso-intestinal and gastric tubes for mechanically ventilated (MV) patients up to May 30, 2024. The process of study selection, quality assessment, and data extraction was conducted independently by two researchers. RevMan 5.3 software was used for meta-analysis.ResultsOur meta-analysis included 8 RCTs, published between 1992 and 2018, encompassing a total of 676 MV patients. The results indicated that naso-intestinal tube feeding, compared to gastric tube feeding, was associated with a significant reduction in the incidence of ventilator-associated pneumonia (VAP) [Risk Ratio (RR) = 0.69, 95% confidence interval (CI) (0.52, 0.92)] and gastric retention (RR = 0.11, 95% CI (0.04, 0.28)). No statistically significant differences were observed in the incidence of aspiration (RR = 0.93, 95% CI (0.35, 2.50)) vomiting (RR = 0.70, 95% CI (0.23, 2.08)), abdominal distension (RR = 0.87, 95% CI (0.29, 2.63)), or diarrhea (RR = 1.10, 95% CI (0.77, 1.55)).ConclusionsThe current evidence indicates that naso-intestinal tube feeding is efficacious in lowering the incidence of VAP and gastric retention among MV patients, without a corresponding escalation in the risk of adverse events, including aspiration, vomiting, abdominal distension, and diarrhea. These insights significantly augment the existing corpus of knowledge pertaining to the optimization of enteral nutrition strategies for patients on mechanical ventilation.

Synthesis and Characterization of MIP Ghost Approach for Selective Extraction of Empagliflozin and Quantification by Liquid Chromatography.

The valid method was developed for analyzing empagliflozin in serum/plasma/urine using a molecularly imprinted ghost polymer-solid-phase extraction approach (MISPE) with liquid chromatographic methodology. Methacrylic acid (MAA) was used as the monomer, 2,2 azobis isobutyronitrile as the initiator and ethylene glycol dimethacrylate as the cross-linker in the free radical polymerization procedure. Empagliflozin was loaded onto the polymer and eluted with 1mL of a 9:1 MeOH:acetic acid solution. The PRONTOSIL C8 (250 × 4 mm × 5u) was used to design the optimized HPLC technique. Phosphate buffer (pH -5): ACN (40:60) was used as the mobile phase with a flow rate of 0.8mL/min, and 230nm was used for detection. Empagliflozin's calibration curve is linear between 0.08 and 200μg/mL. The thresholds for quantification (limit of quantification) and detection (limit of detection) were 0.002 and 0.006μg/mL, respectively. High binding affinity and selectivity were displayed by the polymer, and, at pH8, the polymer's rebinding efficiency was effective. It was discovered that the extraction recovery of the analyte employing the molecular-imprinted solid-phase extraction coupled with high-performance liquid chromatography developed technique was 93% with relative standard deviation (RSD) <2%.

Treatment of Onychomycosis and the Drug-Drug Interactions in Patients with Diabetes Mellitus and Diabetic Foot Syndrome: A Systematic Review.

Background: This systematic review reports on treatments for onychomycosis in patients with diabetes and the drug interactions with other drugs in regard to the complicated diabetic patient profile. Methods: The recommendations in the preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist were applied and the included studies were evaluated using the Consolidated Standards of Reporting Trials (CONSORT) statement and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Searches were conducted in November 2023, using the PubMed (Medline), Scopus, Cochrane Library, and Web of Science databases; studies on antifungal treatments for onychomycosis in patients with diabetes were included. Two authors performed the study selection and data extraction, and any discrepancies between the two reviewers were resolved through discussions with a third reviewer. This review was registered in PROSPERO (CRD42023442107). Results: The systematic review included 10 studies that met the selection criteria. Mycological cures for mild to moderate onychomycosis were: Ageratina pichinchensis (8.6%), 8% ciclopirox (8.6% 24 weeks and 54.3% 48 weeks), 10% efinaconazole (56.5-58.33%), terbinafine (73-76.6%), itraconazole (88.2%), and laser therapy (43.8%). No serious adverse effects or drug interactions were observed because patients with major complications, such as peripheral vascular disease, diabetic neuropathy, liver and renal dysfunction, poorly controlled diabetes, and severe onychomycosis, were excluded. Conclusions: The antifungal treatments described in the included studies are safe for patients with well-controlled diabetes, but there are currently no studies involving patients with diabetes and multiple complications, such as diabetic foot syndrome or severe onychomycosis. Thus, further research is needed in terms of this patient profile.

Restraining Lattice Distortion of LiMn2O4 Facilitates Fluidic Electrochemical Lithium Extraction from Seawater.

Reversible electrochemical extraction using cathode materials shows great potential for selective lithium extraction from low-concentration aqueous sources. However, ion selectivity and structural distortion challenges have limited its application to sources like seawater. Here, we synthesize Nb-modified LiMn2O4 using a simple wet chemistry coating method, introducing minimal structural defects in the LiMn2O4 materials and enhancing stability with a LiNbO3 coating to limit lattice expansion. Additionally, operando XRD reveals reduced lattice distortion during Li+ intercalation/deintercalation. Electrochemical tests show that the composite achieves high stability (over 100 cycles), fast Li+ electrosorption, and robust ion selectivity. Furthermore, utilizing a fluidic electrochemical approach, we extract lithium from simulated seawater (3.5 ppm of Li+), achieving an absorption capacity of 13.8 mg g-1 and an energy consumption of 9.96 Wh g-1.

LiMn2O4 Nanoparticles In Situ Embedded in Carbon Networks for Lithium Extraction from Brine via Hybrid Capacitive Deionization.

Highly selective and efficient extraction of lithium from brine is considered a promising strategy to alleviate the imbalance between supply and demand of lithium resources. However, it is still challenging for lithium ions (Li+) recovery from brine. In this work, LiMn2O4 nanoparticles embedded in situ in carbon networks (LMO-C) derived from metal-organic frameworks by incomplete calcination have been developed for lithium extraction from brine via the hybrid capacitive deionization (HCDI) process. The adsorption capacity of the obtained LMO-C for Li+ is 3.5 mmol g-1, while the separation factor reaches 24.5 at a high Mg:Li ratio of 20. The extraction and insertion of Li atoms in the LiMn2O4 lattice were visually confirmed. In addition, it is found that the synergistic effect between the LMO and the carbon networks is retained in the surface of LMO-C, and the above effect effectively promotes the migration of Li+ and the sustainability of the HCDI process. This work is believed to provide a guidance for the design and synthesis of high-performance HCDI materials for the practical lithium extraction from brine.

Motor Imagery EEG Classification Based on Multi-Domain Feature Rotation and Stacking Ensemble.

Decoding motor intentions from electroencephalogram (EEG) signals is a critical component of motor imagery-based brain-computer interface (MI-BCIs). In traditional EEG signal classification, effectively utilizing the valuable information contained within the electroencephalogram is crucial. To further optimize the use of information from various domains, we propose a novel framework based on multi-domain feature rotation transformation and stacking ensemble for classifying MI tasks. Initially, we extract the features of Time Domain, Frequency domain, Time-Frequency domain, and Spatial Domain from the EEG signals, and perform feature selection for each domain to identify significant features that possess strong discriminative capacity. Subsequently, local rotation transformations are applied to the significant feature set to generate a rotated feature set, enhancing the representational capacity of the features. Next, the rotated features were fused with the original significant features from each domain to obtain composite features for each domain. Finally, we employ a stacking ensemble approach, where the prediction results of base classifiers corresponding to different domain features and the set of significant features undergo linear discriminant analysis for dimensionality reduction, yielding discriminative feature integration as input for the meta-classifier for classification. The proposed method achieves average classification accuracies of 92.92%, 89.13%, and 86.26% on the BCI Competition III Dataset IVa, BCI Competition IV Dataset I, and BCI Competition IV Dataset 2a, respectively. Experimental results show that the method proposed in this paper outperforms several existing MI classification methods, such as the Common Time-Frequency-Spatial Patterns and the Selective Extract of the Multi-View Time-Frequency Decomposed Spatial, in terms of classification accuracy and robustness.