Selective Properties Research Articles

Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.

Hydrogen has been shown to exhibit selective antioxidant properties against hydroxyl radicals, and exerts antioxidant and anti-inflammatory effects. The monocrotaline-induced model of pulmonary hypertension is suitable for studying substances with antioxidant activity because oxidative stress is induced by monocrotaline. On day 1, male Wistar rats were subcutaneously injected with a water-alcohol solution of monocrotaline or a control with an only water-alcohol solution. One group of monocrotaline-injected animals was placed in a plastic box that was constantly ventilated with atmospheric air containing 4% of molecular hydrogen, and the two groups of rats, injected with monocrotaline or vehicle, were placed in boxes ventilated with atmospheric air. After 21 days, hemodynamic parameters were measured under urethane narcosis. The results showed that, although hydrogen inhalation had no effect on the main markers of pulmonary hypertension induced by monocrotaline injection, there was a reduction in systemic blood pressure due to its systolic component, and a decrease in TGF-β expression, as well as a reduction in tryptase-containing mast cells.

Highly elastic photothermal nanofibrillated cellulose aerogels for solar-assisted efficient cleanup of viscous oil spill

Frequent oil spills and illegal industrial pollutant discharge cause ecological and resource damages, so it is necessary to establish efficient adsorption and recovery strategies for oils in wastewater. Herein, inspired by solar-driven viscosity-breaking, we propose a facile approach to fabricate multifunctional nanofibrillated cellulose-based aerogel with high elasticity, excellent photothermal conversion, efficient selective oil adsorption and antibacterial properties. Firstly, copper sulfide (CuS) nanoparticles were in situ deposited on the template of oxidative nanofibrillated cellulose (ONC), aiming at achieving efficient photothermal effect and antibacterial properties. Ethylene glycol diglycidyl ether (EGDE) was employed to establish multiple crosslinking network between CuS@ONC and polyethyleneimine (PEI). A thin hydrophobic PMTS layer deposited on the surface of aerogel via a facile gas-solid reaction ensured stable oil selectivity. The resulting composite aerogel can rapidly adsorb oil under solar self-heating, significantly reducing the adsorption time from 25 to 5 min. Furthermore, it exhibits excellent adsorption capacities for various oils, retaining over 92 % of its initial capacity even after 20 adsorption-desorption cycles, and the antibacterial properties extend its lifespan. This work offers a promising method for constructing multifunctional aerogels for efficient oil-water separation, especially beneficial for high-viscosity and high-melting-point oil cleanup.

Preparation of chitosan mesoporous membrane/halloysite composite for efficiently selective adsorption of Al(III) from rare earth ions solution through constructing pore structure on substrate

The removal of impurity Al(III) from rare earth ion solution by selective adsorption method was one of the challenging tasks. Herein, calcination and acid dissolution treatment were used to construct the pore structure for the halloysite substrate (Hal-650-H) and provide conditions for the formation of the chitosan mesoporous membrane to prepare composite (Hal-H-2CS). The selective adsorption properties and mechanism of the Hal-H-2CS for Al(III) in the rare earth ion solution were studied. The results showed that the formation of mesoporous structures for chitosan provided abundant sites for the adsorption of Al(III). Hal-H-2CS showed remarkable selective adsorption properties for Al(III) in a wide pH range and the binary mixtures with high content of Al(III) or La(III). The maximum adsorption capacity of Al(III) was 106 mg/g, while the adsorption capacity of La(III) was only 1.41 mg/g at pH 4.0. In addition, the Hal-H-2CS exhibited excellent regeneration and structural stability. The remarkable selective properties of Hal-H-2CS was achieved by the synergistic effect between chitosan mesoporous membrane and Hal-650-H, the main adsorption sites were the OH, NH2, CONH2 of chitosan and the oxygen sites of the Hal-650-H. This work provides a new strategy for the design and preparation of outstanding selective adsorbent for Al(III).

Metal-Organic framework based on N, N, N’, N’-Tetrakis(4-carboxyphenyl)-1,4-phenylenediamine: Magnetic properties and selective luminescence sensing properties and DFT calculation

A linear fluorescent pyridyl ligand, 9,10-di(4-pyridyl)anthracene (dpa), and N,N,N’,N’-Tetrakis(4-carboxyphenyl)-1,4-phenylenediamine (H4TCPPDA) were selected as organic ligands to synthesize a new Co(II) metal–organic framework, namely {[Co2(TCPPDA)(dpa)(H2O)2]·3DMF·3H2O}n (CoMOF-s1). In the crystal structure of CoMOF-s1, the Co(II) was connected by TCPPDA4- and dpa to construct a three-dimensional framework, which features a 2, 4, 6-c network topology with the point symbol of {44.62.88.12}{44.62}{8}. Magnetic analyses revealed an overall antiferromagnetic coupling between two adjacent metal centers. Moreover, luminescence sensing experiments demonstrated that CoMOF-s1 displays highly sensitive and selectivity properties in the detection of nitrofuran antibiotics (nitrofurazone, NFZ, nitrofurantoin, NFT) with low detection limits of 0.15 μM and 0.23 μM, respectively. Furthermore, possible reasons for the quenching response were further explored by Powder X-ray diffraction (PXRD), UV–vis, and density functional theory (DFT) calculation.

Formulation of an Efficiency Model Valid for High Vacuum Flat Plate Collectors

High Vacuum Flat Plate Collectors (HVFPCs) are the only type of flat plate thermal collectors capable of producing thermal energy for middle-temperature applications (up to 200 °C). As the trend in research plans is to develop new Selective Solar Absorbers to extend the range of HVFPC application up to 250 °C, it is necessary to correctly evaluate the collector efficiency up to such temperatures to predict the energy production accurately. We propose an efficiency model for these collectors based on the selective absorber optical properties. The proposed efficiency model explicitly includes the radiative heat exchange with the ambient, which is the main source of thermal losses for evacuated collectors at high temperatures. It also decouples the radiative losses that depend on the optical properties of the absorber adopted from the other thermal losses due to HVFPC architecture. The model has been validated by applying it to MT-Power HVFPC manufactured by TVP-Solar. The dissipative losses other than thermal radiation were found to be mostly conductive with a linear coefficient k = 0.258 W/m2K. The efficiency model has been also used to predict the energy production of HVFPCs equipped with new, optimized Selective Solar Absorbers developed in recent years. Considering the 2019 meteorological data in Cairo and an operating temperature of 250 °C, the annual energy production of an HVFPC equipped with an optimized absorber is estimated to be 638 kWh/m2.

Design and Fabrication of a Novel Corona-Shaped Metamaterial Biosensor for Cancer Cell Detection.

The early detection and diagnosis of cancer presents significant challenges in today's healthcare. So, this research, suggests an original experimental biosensor for cell cancer detection using a corona-shaped metamaterial resonator. This resonator is designed to detect cancer markers with high sensitivity, selectivity, and linearity properties. By exploiting the unique properties of the corona metamaterial structure in the GHz regime, the resonator provides enhanced interaction of electromagnetic waves and improved detection skills. Through careful experimental, simulation, and optimization studies, we accurately demonstrate the resonator's ability to detect cancer. The proposed detection system is capable of real-time non-invasive cancer detection, allowing for rapid intervention and better patient outcomes. The sensitivity value was confirmed through simulation, estimated at 0.1825 GHz/RIU. The results of two different simulation methods are used: the simulation software CST Studio Suite (version 2017) based on the finite element method (FEM), and the simulation software ADS (version 2019) based on the equivalent circuit method, thereby increasing confidence in the convergence of simulation and measurement results. This work opens new avenues for developing advanced detection technologies in the field of oncology, and paves the way for more effective cancer diagnosis. The experimental study verified that this realized sensor has very small frequency shifts, significantly small electrical dimension and miniaturization, high sensitivity, and good linearity. The suggested configurations showed a capacity for sensing cancer cells in the GHz regime.

Crn (n=1–4) clustered (8, 0) single-walled CNT: Comparison of gas-sensitive properties to air discharge pollutants (CO, NOx)

Air is a good insulating medium under normal conditions. The insulation performance of many electrical equipment is closely related to air. The detection of air decomposition pollutants is considered to be one of the effective ways to diagnose the fault of air insulated power equipment. Based on the first-principles, the adsorption and sensing characteristics of Single-walled CNT modified by transition metal clusters (Crn) for air discharge pollutants (CO, NOx) were analyzed. Firstly, through the modeling and analysis of different doping sites, four most stable models of Crn doped SWCNT are obtained, and their resistance is briefly analyzed. On the basis of these four configurations, the most stable adsorption configurations were found. The corresponding adsorption energy, adsorption distance and transfer charge are obtained. Then, the differential charge density, frontier molecular orbitals, adsorption selectivity and desorption properties of each system were analyzed. The result is that Crn-SWCNT surface has a good adsorption capacity for pollutants. The theoretical recovery time is not ideal at room temperature. However, CO can be rapidly desorbed from the surface of Crn-SWCNT at extremely high temperatures. Interestingly, Crn-SWCNT can be used as solid adsorption materials for purifying CO, NOx. This work provides a new idea for clean air to treat air discharge pollutants.

Improvement on solar selective absorption properties of anodic aluminum oxide photonic crystal films by electrodeposition of silver

Solar selective absorption films based on anodic aluminum oxide (AAO) photonic crystals were prepared by an anodization under periodic current-pulses, subsequently with an alternating current electrodeposition of Co and Ag in sequence. The phase structure, microstructure, and solar selective absorption properties of the Co–Ag electrodeposited film were investigated in comparison with a Co electrodeposited counterpart. Moreover, the stability of the properties against thermal annealing was examined for the two films. A one-dimensional photonic crystal structure was verified for the AAO part in both films, with the first-order photonic bandgap occurring at around 4 μm, while the metals were confirmed to be deposited at the bottom of the AAO part in the form of nanoparticles. For the Co–Ag electrodeposited film, the Ag nanoparticles were deposited over those of Co. The Ag electrodeposition not only was contributive to the solar selective absorption properties, but also substantially improved the stability of the properties against thermal annealing. The Co–Ag electrodeposited film exhibited an infrared emissivity of 0.12, a solar absorptivity of 0.94, and a spectral selectivity of 7.83 before experiencing thermal annealing, while retained a decent spectral selectivity of 6.00 after being annealed in air at 300 °C for 24 h.

MXene-based membranes in water treatment: Current status and future prospects

Emerging highly selective MXene-based membranes have drawn a greater scientific interest in the field of water treatment due to their ion-selective and controlled molecular transport characteristics. However, MXene-based membranes have limitations in water treatment due to the difficulties including permeability-selectivity trade-off, swelling, fouling, oxidation, etc. Thus, a better understanding of the rational structural design principles of the membranes and their separation mechanisms are essential to further their development in water treatment. This review provides a concise overview of the key timeline in the fabrication of MXene-based membranes, the membrane characterization approaches used to understand their structure-property correlations, and the present difficulties in synthesizing high-performance MXene-based membranes. To overcome these challenges, new designing approaches are comprehensively reviewed to enhance the permeability, selectivity, stability, and antifouling properties of MXene-based membranes. These approaches include physical intercalation, chemical cross-linking, membrane surface modification, etc. Then, the separation mechanisms involved in the membranes in water treatment are presented, followed by the related applications. Looking forward, the perspective is provided on the future research directions for further advancing the membranes. This timely review may help to bridge the gap between academic research and industrial needs of MXene-based membranes for water treatment.

Lethal and sublethal effects of carlina oxide on Tetranychus urticae (Acari: Tetranychidae) and Neoseiulus californicus (Acari: Phytoseiidae).

Tetranychus urticae Koch, is a polyphagous and damaging pest, presenting several resistant populations worldwide. Among new and more environmentally friendly control tools, botanical pesticides represent a valuable alternative to synthetic ones within integrated pest management strategies. Accordingly, we investigated the lethal and sublethal effects of carlina oxide isolated from Carlina acaulis (Asteraceae) roots on T. urticae and its natural enemy, the predatory mite, Neoseiulus californicus (McGregor). Carlina oxide (98.7% pure compound) was used for acaricidal tests on eggs, nymphs, and adult females of T. urticae (concentrations of 312.5, 625, 1250, 2500 and 5000 μL L-1 ), and eggs and females of N. californicus (1250 and 5000 μL L-1 on eggs and females, respectively). Behavioral two-choice tests were also conducted on phytoseiid females. Carlina oxide toxicity was higher on T. urticae females than nymphs (median lethal dose 1145 and 1825 μL L-1 , respectively), whereas egg mortality and mean hatching time were significantly affected by all tested concentrations. A decreasing daily oviposition rate for T. urticae was recorded with concentrations ranging from 625 to 5000 μL L-1 , whereas negative effects on the population growth rate were recorded only with the three higher concentrations (1250, 2500 and 5000 μL L-1 ). No toxic effect on N. californicus females was found, but a strong repellent activity lasting for 48 h from application was recorded. Carlina oxide reduced longevity and fecundity of T. urticae adults, but not of N. californicus. This selective property allows us to propose it as a novel active ingredient of ecofriendly acaricides for T. urticae management. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

STRUCTURE AND PROPERTIES OF THE GLOMERULAR FILTRATION BARRIER OF VERTEBRATES: ROLE OF CHARGE FOR FILTERING PROTEINS

The renal glomerulus is a unique structure that distinguishes the nephrons of vertebrates from the nephridia of invertebrate animals, providing a direct connection between the circulatory and excretory systems and the most effective control of the composition of the internal environment due to the significant intensification of filtration. The modern ideas about the structure of the glomerular filtration barrier in representatives of all major groups of vertebrates (cyclostomes, fishes, amphibians, reptiles and birds, mammals) were reviewed. Emphasis is placed on the role of the charge of the glomerular barrier structures for its selective properties; approaches to studying the contribution of the anionic components of the renal filter to preventing the loss of plasma proteins are described. The main models of the glomerular filter functioning presented in the literature are considered. Negative charge has been demonstrated to be a distinctive feature of the glomerular filter in all vertebrates. It was shown that a multiple increase of the glomerular filtration rate (from lower vertebrates to birds and mammals) was accompanied by a number of structural changes that ensured the passage of a significant volume of water and dissolved low-molecular substances through the glomerular filter: an increase in the number and ordering of fenestrae in the endothelium of glomerular capillaries, thinning of the glomerular basement membrane and complete exclusion of cellular elements from it. It has been shown that comparative physiological data on the glomerular filter in different groups of vertebrates most strongly confirm the electrokinetic model of the glomerular filtration, since it explains the importance of the evolutionarily conservative structure of podocytes and the role of a set of fixed anionic charges in the filter wall to prevent the loss of macromolecules (primarily proteins) from blood at different intensities of the ultrafiltration.

Overview of Determination of Biopharmaceutical Properties for Development Candidate Selection.

The physicochemical and biopharmaceutical properties of putative drug molecules impact their performance in both in vitro and in vivo studies. The design and selection of molecules with drug-like properties assist in the selection of drug candidates with a higher probability of success in the development process. Described in this overview are commonly used approaches for measuring compound solubility, permeability, and partitioning in drug discovery and development. The utility of these methods in the drug discovery process and product development is discussed. The evaluation of crystallinity and physicochemical stability in relation to biopharmaceutical properties and in assessing the potential for successful development is also discussed. © 2023 Wiley Periodicals LLC.

Thermodynamics of Sorption of Organic Compounds by Sorbents Based on Supramolecular Liquid Crystal HPFAB and β-Cyclodextrin Derivatives under Gas Chromatography Conditions

Using gas chromatography, we studied the influence of the nature of substituents in the β-cyclodextrin (CD) molecule on the sorption properties and the possibility of complex formation with the macrocycle of 26 organic compounds (hydrocarbons and alcohols) in binary sorbents based on the smectic–nematic supramolecular liquid crystal 4-(3-hydroxypropyloxy)-4'-formylazobenzene (HPOFAB) and four derivatives β-CD. It has been established that the nature of the substituents in the β-CD molecule significantly affects the manifestation of solvation interactions between LC and macrocyclic additive and, as a consequence, the mesomorphic, sorption, and selective properties of the studied composite sorbents.

Anti-inflammatory and antioxidant properties of Agelas sp., Ircinia sp., and Aaptos suberitoides

Reactive oxygen species (ROS) and cyclooxygenase-2 (COX-2) can be therapeutic targets for inflammatory diseases. COX-2 expression which can be triggered by ROS might consequently promote inflammation. Inhibition of ROS by the antioxidant, however, may prevent or decrease the expression of COX-2. In this study, the antioxidant and anti-inflammatory properties of the hexane (H), dichloromethane (DCM), and methanol-water (MW) extracts of marine sponges Agelas sp. (Asp), Ircinia sp. (Isp), and Aaptos suberitoides (As) were determined. The correlation between their antioxidant properties and ability to inhibit COX enzymes was also established. The MW extracts of the marine sponges and the AsDCM contain a significant (p<0>50% of the COX-2 and gave a selectivity index (COX-2/COX-1) >1.0. This suggests that the extracts can be sources of compounds with promising and selective inhibitory properties against COX-2. Correlation analysis further showed a positive linear correlation between the extracts’ inhibitory activity against the COX enzymes and their TPC, reducing power, and DPPH radical scavenging activity. Thus, the antioxidant activity of the extracts may have influenced their anti-inflammatory property via COX inhibition.

Research Progress of Selective Laser Melting Forming Medical Implants

Abstract:: Selective laser melting technology has the advantages of rapid manufacture, high precision, and the ability to produce fine structures. Medical implants made using selective laser melting technology have high precision and excellent mechanical properties that meet the needs of patients and make medical implants more promising in the medical field. This paper reviews the progress of research on selective laser melting of medical implants. This paper draws on numerous journals and patents. This paper firstly reviews the classification of medical implants, mainly including hip implants, knee implants, maxillo-craniofacial implants and spinal implants. Secondly, the common porous structure design methods, the effect of porous structure on the mechanical properties of the implant, and the effect of pore structure on the growth properties of porous titanium alloy bone are summarised. Finally, the process of manufacturing titanium alloy implants by selective laser melting technology is described. Medical implants made by selective laser melting have excellent properties and are widely used in the medical field. Compared to traditional mechanical processing methods, selective laser melting technology can better preserve the properties of the raw material, while providing higher precision and faster preparation. However, selective laser melting has a number of drawbacks, including differences in material microstructure, reduced strength and plasticity, inadequate surface treatment, and enhanced safety and reliability. Further scientific research and technological innovation are needed to solve these problems. In the future, as technology continues to innovate and develop, SLM technology will become more mature, resulting in implants that are more natural, suitable for the body and long-lasting. At the same time, as implants are personalised, there will be a huge market demand and development opportunities. In addition, the continuous improvement of regulatory policies is expected to further promote the market development and application of medical implants.

Toward understanding the microstructure characteristics, phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic devices. The essential magnetic properties of Nd-Fe-B magnets, particularly coercivity and remanent magnetization, are significantly influenced by the phase characteristics and microstructure. In this work, Nd-Fe-B magnets were manufactured using vacuum induction melting (VIM), laser directed energy deposition (LDED) and laser powder bed fusion (LPBF) technologies. The microstructure evolution and phase selection of Nd-Fe-B magnets were then clarified in detail. The results indicated that the solidification velocity (V) and cooling rate (R) are key factors in the phase selection. In terms of the VIM-casting Nd-Fe-B magnet, a large volume fraction of the α-Fe soft magnetic phase (39.7 vol.%) and Nd2Fe17B x metastable phase (34.7 vol.%) are formed due to the low R (2.3 × 10−1 °C s−1), whereas only a minor fraction of the Nd2Fe14B hard magnetic phase (5.15 vol.%) is presented. For the LDED-processed Nd-Fe-B deposit, although the Nd2Fe14B hard magnetic phase also had a low value (3.4 vol.%) as the values of V (<10−2 m s−1) and R (5.06 × 103 °C s−1) increased, part of the α-Fe soft magnetic phase (31.7 vol.%) is suppressed, and a higher volume of Nd2Fe17B x metastable phases (47.5 vol.%) are formed. As a result, both the VIM-casting and LDED-processed Nd-Fe-B deposits exhibited poor magnetic properties. In contrast, employing the high values of V (>10−2 m s−1) and R (1.45 × 106 °C s−1) in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase (55.8 vol.%) directly from the liquid, while the α-Fe soft magnetic phase and Nd2Fe17B x metastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B magnet. Additionally, crystallographic texture analysis reveals that the LPBF-processed Nd-Fe-B magnets exhibit isotropic magnetic characteristics. Consequently, the LPBF-processed Nd-Fe-B deposit, exhibiting a coercivity of 656 kA m−1, remanence of 0.79 T and maximum energy product of 71.5 kJ m−3, achieved an acceptable magnetic performance, comparable to other additive manufacturing processed Nd-Fe-B magnets from MQP (Nd-lean) Nd-Fe-B powder.

Ultra-sensitive trace NO2 detection based on quantum dots-sensitized few-layer MXene: A novel convincing insight into dynamic gas-sensing mechanism

It is critical for MXene to overcome the constraints of weak gas adsorption capacity, poor sensitivity and limited selectivity properties. Herein, quantum dots (QDs)-sensitized few-layer Ti3C2Tx was successfully constructed for efficient NO2-sensing. The ideal doping content was investigated according to multiple structural analysis and sensing-properties. Impressively, the FLTS-2 sensor displays a significant 42.05-fold response (60.38%, 500-ppb NO2) compare to pure MXene (1.43%). It also exhibits ideal selectivity, well long-term stability and lower detection limit (0.83-ppb), demonstrating its considerable potential for trace-level monitoring and practical applications. Meanwhile, a novel convincing dynamic gas-sensing mechanism is proposed to elucidate the enhancement of sensing-capabilities, including gas diffusion/adsorption, selective mechanisms, DFT calculations (37 models, 100 images) and QDs-sensitization mechanisms. Strikingly, dynamic gas-sensing mechanism proves that the surface functionalization of QDs modifications strongly improves the adsorption behavior and significantly facilitates the electron transfer of NO2 molecules, thus enhancing the sensing performance. The present experiment and mechanism analysis not only highlight the promising combination of 2D/0D MXene/PbS heterostructures, but also provide a theoretical perspective for designing of MXene-based sensors for trace NO2 detection.

Recent Advances in Orthodontic Archwires: A Review.

Orthodontic archwires are the primary aid to achieve desirable tooth movement. These wires are also considered to be the backbone of orthodontic treatment. Orthodontic archwires are available in various materials. The journey of advancement of these wires has shown immense growth in aesthetics as well as the mechanical properties of the materials used to ultimately provide patient satisfaction. This review highlights the properties of orthodontic archwires and the disadvantages associated with these wires which limit their use in today's era. The major role of the clinician is to choose the most appropriate alloy as per the needs of the patient. This can be done by accurately analyzing the properties of every material. The introduction of robotic systems in bending archwires and the properties of newer materials like organic polymer wires and bactericide archwires have also been described in this review. Thus, this review article focuses on the recent advances in orthodontic archwires and their properties for selection as per need.

A novel study on influence of ground surface boundary conditions on thermal performance of vertical U-shaped ground heat exchanger

To better understand the influence of ground surface boundary conditions (GSBC) on the thermal performances of U-shaped ground heat exchangers (UGHE), this study proposes a numerical model with one energy balance boundary condition (EBBC) considering the spectrally selective properties of ground. This study comprehensively discusses the effects of operation and design parameters on the thermal responses of various GSBCs and UGHE. Additionally, the geographical performances of the EBBC are compared. The main results indicate that implementing EBBC in UGHE reduces prediction errors for water and borehole wall temperatures, with a maximum decrease of 1.70 °C and 1.78 °C, respectively. Regarding the average water temperature, the variation induced by different GSBCs can be reduced by 51.0% as the borehole depth increases from 50 to 125 m. Similarly, the difference induced by different GSBCs can be reduced by 22.7%, with ground thermal conductivity decreasing from 3.0 to 1.5 W/(m·K). Based on the geographical analysis, the convective GSBC can be imposed on UGHE for engineering approximation in only temperate and tropical regions. For other climate regions, the use of EBBC is recommended. Finally, the sensitivity analysis results indicate that borehole depth is the most important dependent variable, followed by ground conductivity and volumetric heat capacity.

Efficacy of dotinurad in patients with severe renal dysfunction.

Although hyperuricemia is associated with the progression of chronic kidney disease (CKD), a reduction in CKD progression by uric acid (UA)-lowering therapy has been controversial. Recently, dotinurad, a uricosuric drug with selective urate reabsorption inhibitory properties, has been developed. However, its efficacy in lowering serum UA levels and its effects on renal function in patients with severe renal dysfunction are unclear. Thus, this study aimed to determine the effects of dotinurad on renal function in patients with severe renal dysfunction. Data from 53 outpatients with hyperuricemia who newly received dotinurad between December 2020 and October 2022 were retrospectively analyzed. The mean baseline estimated glomerular filtration rate (eGFR) was 38.7 ± 17.0mL/min/1.73m2. The patients were divided into three groups based on their baseline eGFR: eGFR < 30 (n = 17), 30 ≤ eGFR < 45 (n = 17), and eGFR ≥ 45 (n = 19). The mean follow-up period was 9.8 ± 4.5 (range, 3-21) months. Serum UA levels significantly decreased in all groups. Although eGFR did not significantly change in patients with 30 ≤ eGFR < 45 and eGFR ≥ 45 (P = 0.918 and P = 0.535, respectively), it improved significantly in patients with eGFR < 30 (P = 0.032). The proportion of patients with improved eGFR was significantly higher in patients with eGFR < 30 (P = 0.038) than in patients with 30 ≤ eGFR < 45 and eGFR ≥ 45. In the multivariate logistic regression analysis, baseline eGFR < 30 and achieving a serum UA level of ≤ 6.0mg/dL were significantly associated with improved eGFR (P = 0.033 and P = 0.015, respectively). Dotinurad may have UA-lowering effects and the potential to improve kidney function in patients with severe renal dysfunction.