The off-axis three-mirror anastigmatic (TMA) optical system has the advantages of eliminating all primary aberrations, having no aperture obscuration, no chromatic aberration, and good environmental adaptability, making it essential in high-performance optical instruments. Freeform surfaces, with their rich degrees of freedom (DOFs) in mathematical representation, positively affect the image quality and sensitivity of optical systems. When applied correctly to off-axis TMA optical systems, they can achieve fast F-numbers, large fields of view (FOVs), and long focal lengths. There are dozens of configurations for off-axis TMA optical systems, and freeform surfaces can be combined in numerous ways within these systems. This paper first analyzes the sensitivity of off-axis TMA optical systems with different configurations, selects the configuration with the lowest sensitivity, and combines it with a low sensitivity freeform surface combination to achieve high-performance freeform off-axis TMA optical systems with low sensitivity.