Selcuk University Faculty Research Articles

Evaluation of sialic acid, malondialdehyde and glutathione levels in infertile male

Introduction and objectivesAround 15% of productive couples in the world are infertile. Recent years, biochemical mechanisms leads to male infertility are started to research. Redox regulation and oxidative stress (OS) show importance in the pathogenesis of infertility in male. Malondialdehyde (MDA) and Glutathione (GSH) are biochemical indicatives of sperm damage by reactive oxygen species (ROS). In addition, sperm are coated with a thick glycocalyx rich in sialic acids. It is aimed to determine and evaluate the differences between normozoospermic and oligozoospermic individuals according to sialic acid, MDA and GSH concentrations and correlations between spermyogram and these parameters. Material and methodsThis study was carried out on seminal plasma of individuals who admitted to Selcuk University Faculty of Medicine IVF Unit Andrology Laboratory. The groups were divided into two as normozoospermics (n=30, sperm concentration≥15million/mL), and oligozoospermics (n=30, sperm concentration<15million/mL). Spermyogram were evaluated regarding WHO (2010) Kruger criteria. GSH, MDA and sialic acid concentrations were analyzed in seminal plasma. Diagnostic performance of sialic acid has been determined with ROC curve analysis. ResultsSialic acid levels were significantly lower in Normozoospermic than Oligozoospermic individuals (p<0.0001), MDA and GSH levels were not differ significantly in both groups (p>0.05). Sialic acid correlated significantly with most of the spermyogram findings. When diagnostic performance of sialic acid was evaluated, the cut off value of sialic acid found as 4.175nmol/mL by ROC curve. ConclusionHigh seminal plasma sialic acid levels may be used as a biomarker and sialic acid is important determinant in oligozoospermia.

The relationship between helicobacter pylori infection and nodular antral gastritis in pediatric patients

Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It is a common infectious agent in children. In this study, we aim to evaluate the demographic data, and the clinical and histopathological findings of pediatric patients that underwent upper gastrointestinal endoscopy (UGSE) in our clinic. Between July 2017 and February 2019, 636 patients applied to the Selcuk University Faculty of Medicine, Pediatric Gastroenterology outpatient clinic with complaints of epigastric abdominal pain and/or dyspeptic complaints. Patients who underwent upper gastrointestinal endoscopy were evaluated retrospectively. Data on age, gender, family history of peptic ulcer disease, and family history of H. pylori were recorded. Endoscopic and histopathological findings were collected from medical records. 235 (36.9%) of the patients participating in the study were male, and 401 (63.1%) were female. H. pylori infection was detected in 277 (43.6%) patients as a result of histopathological examination of H. Pylori, urea breath tests and H. Pylori antigen tests in the stools of patients are included in the study. Nodular antral gastritis was detected in 282 (44.3%) of our patients endoscopically. H. pylori was detected in 83.7% (n: 236) of the 282 patients with nodular antral gastritis. Nodular antral gastritis was observed to be significantly higher in H. pylori-positive patients than in H. pylori-negative cases (odds ratio (OR), 39.16; 95% confidence interval (CI), 24.88-61.64; p: <0.001). Nodular antral gastritis is caused by chronic H. pylori infection. It is predicted that early detection of H. pylori infection in children is important and may decrease complications later in life. Our study shows that all the markers evaluated are very good predictors of H. pylori infection. Positive significant association was found between the prevalence of H. pylori infection and nodular antral gastritis.

Comparison of endoscopic and microscopic methods in stapedotomy: a retrospective analysis.

The goal of the present study was to compare the audiologic results, complications, and advantages/disadvantages of endoscopic and microscopic stapedotomy. Patients who experienced stapedotomy surgery in the Ear Nose Throat Clinic (ENT) of Selcuk University Faculty of Medicine between September 2011 and January 2018 were included in the study. The data of all patients were analyzed and divided into two groups. Those who underwent endoscopic stapedotomy were included in group I, and patients who underwent microscopic stapedotomy formed group II. Surgical findings, complications, and operation times were compared for the two groups. Air and bone conduction thresholds were evaluated at the frequencies of 500, 1000, 2000, and 4000Hz pre- and postoperatively at 1, 3, and 6months, and the mean (± SD) air-bone gap value was recorded. While the mean pre- and postoperative air-bone gaps were 34.38 ± 7.47dB (23-53dB) and 9.69 ± 4.43dB (0-19dB), respectively, in group I, 34.32 ± 7.57dB (23-6dB) and 9.62 ± 4.25dB (2-23dB) were the respective means calculated in group II (p < 0.05). When the mean postoperative air-bone gap was compared, there was no statistically significant difference between the two groups (p = 0.774). The mean operative times for groups I and II were 57.22 ± 4.37min and 63.70 ± 7.34min, respectively (p < 0.001). The requirement for chorda tympani nerve manipulation and scutum curettage was significantly less in group I compared to group II (p = 0.003). Postoperative dysgeusia and postoperative pain were found to be higher in group II than group I, but they were not statistically significant (p > 0.05). Endoscopic stapedotomy displayed similar audiological results, shorter operation times, and similar complication rates, as well as being a less invasive surgery, compared to the microscopic approach.

MEME KANSERİ OLAN HASTALARDA SERUM HOMOSİSTEİN DÜZEYLERİNİN ARAŞTIRILMASI

Objective: Scientific studies are continuing on many molecules in order to be used in the diagnosis of diseases. The fact that even one of these molecules can be used for diagnosis is very important for clinicians in diagnosing the disease. For this purpose, intensive studies continue on homocysteine and arginine.&#x0D; For these reasons, in this study, we aim to determine whether there is any change in homocysteine and arginine levels in the serum of blood samples of breast patients and to explain its relationship with breast cancer.&#x0D; Material Materials and Methods: We carried out our work in Selcuk University Faculty of Medicine Biochemistry Metabolism Laboratory. Our study included 20 controls, 20 breast Ca, 20 metastasis patients. Blood collected from breast cancer patients stored at -80 ° C until biochemical analysis is performed. Homocysteine and arginine levels measured in the sera obtained from the blood samples taken. The levels of proteins were measured at 470 nm in the NMRspectrophotometer. To measure homocysteine levels were injected into the mass spectrometer for chromatography.&#x0D; Results: In the evaluation, a statistical increase was observed in Arginine, Arginine / ADMA levels in patients with breast Ca, and Homocysteine levels in patients with metastases compared to the control group. When the breast cancer error group was compared with the metastasis group, the homocysteine level increased statistically, while the Arginine / ADMA level decreased statistically.&#x0D; Conclusion: Based on the results we obtained, it is thought that these markers can be used during the diagnosis and treatment of breast cancer patients.

An evaluation on coping with stress of Selcuk University Faculty of Veterinary Medicine students: Covid-19 pandemic process

An evaluation on coping with stress of Selcuk University Faculty of Veterinary Medicine students: Covid-19 pandemic process

Impact of Education on Student Nurses' Advocacy and Ethical Sensitivity.

The nursing literature emphasizes that there are still inadequacies, differences, and inconsistencies in the definition of nurses' advocacy role, and that nursing education plays an important role in educating nurses for patient advocacy. The aim of the present study is to determine the effects of advocacy education onsocial justice advocacy and ethical sensitivity. Pre-test, post-test, parallel group, randomized controlled study. The study was carried out on 80 undergraduate nursing students in Turkey. Students was divided into experimental (40) and control (40) groups. Experimental group received advocacy education cirruculum. Both groups were applied as Socio-Demographic Characteristics, as pre- test and post-tests Social Justice Advocacy Scale, and Moral Sensitivity Questionnaire. The data were statistically evaluated with, the chi-square test, Two-Way Anova. The study was approved by Selcuk University Faculty of Health Sciences Non-Interventional Clinical Research Ethics Committee (09.25.2019/1218). Written informed consent was obtained from all participants. The pre-test score of the intervention group and that of the control group were similar(p > 0.05). The study group's post-test score was significantly higher than its pre-test score and the post-test score of the control group "social justice advocacy skills" and "moral sensitivity Questionnaire." In two-way analysis of variance in repeated measures, there was a significant main effect of the type of groups. The two-way ANOVA results in repeated measures showed that group-time interaction was significant. The advocacy education cirruculum the experimental group increased in the social justice advocacy knowledge, attitude and skills and moral sensitivity. The advocacy education cirruculum the experimental group increased the social justice advocacy skills and moral sensitivity. The Advocacy education cirruculum can be suggested to be integrated into the undergraduate nursing curriculum.

Acute Rheumatic Fever Cases Presented with Enthesitis: A Different View on Acute Rheumatic Fever

Background: Acute rheumatic fever (ARF) is a non-suppurative inflammatory disease that develops after group A Beta hemolytic streptococcal pharyngitis, primarily involving the heart, joint, central nervous system, skin and subcutaneous tissue. Today, Jones criteria; that were modified in 2015, are used for diagnosis. Our aim in this study is to examine the patients diagnosed with acute rheumatic fever in our clinic and presented with enthesitis.&#x0D; Methods: The type of study is case report. Five patients who were admitted to the Pediatric Rheumatology Clinic of Selcuk University Faculty of Medicine were diagnosed with acute rheumatic fever and presented with enthesitis, between 2017- 2019 were examined retrospectively. Their demographic, clinical laboratory and echocardiographic data were examined. The presence of enthesitis in all patients was established with one or more of the options of clinical examination, ultrasonography, magnetic resonance imaging, and/or orthopedics opinion. &#x0D; Results: While the clinic of the patients improved with the treatment for enthesitis, acute phase reactants did not fall and additional clinical findings appeared. Our observations suggested that acute rheumatic fever could apply to us not only with arthritis and arthralgia, but also with the enthesitis clinic. Therefore, we think that if the laboratory data are compatible among the differential diagnoses in patients presenting with enthesitis, acute rheumatic fever should also be considered, and careful physical examination and echocardiography should be performed for this purpose.&#x0D; Conclusion: In relation to the pathogenesis of the rheumatological diseases, new clinical situations are emerging day by day, and in this way, the diseases are better understood and classified. In conclusion, we think that ARF can be encountered not only with arthritis and arthralgia but also with enthesitis clinics, and echocardiographic imaging should not be ignored in patients with enthesitis clinic who have high acute phase reactants and who do not meet the enthesitis-related juvenile idiopathic arthritis criteria.

Morphological and Physiological Effects of Drought Stress on Some Strawberry Cultivars

This study was carried out in the Selcuk University Faculty of Agriculture Department of Horticulture Research and practice greenhouse. In the study, Ata77, Bolverim77, Doruk77, Dorukhan77, Eren77, Erenoğlu77 and Hilal77 strawberry varieties obtained from Yalova Atatürk Horticultural Research Institute were used. Sewing 5-6 leaf stage seedlings strawberries made after the arrival of field capacity after the leaves of plants irrigation turgor until drought. After implementation of the varieties of drought with healing and drought period of watering again losses to determine. Leaf relative water content (LRWC) loss 15. by the end of the day up to Ata77 cultivar (51.51%) while the cultivar Dorukhan77 with at least lost 29.74%. Improvement of then 7. day also represents the maximum improvement in the kind of Dorukhan77 (% 5.38), while according to the day of check out lost 17.57% Ata77. Membrane permeability up to Ata77 cultivar (91.32%) while the lowest membrane radicals Doruk77 (71.46%). The drought is finally low stomatal conductivity Ata77 (10.70 mmol m-2 h-1) from the rubrics communicate the highest stomatal conductivity Doruk77 (106.76 mmol m-2 h-1) measured from. Measured in terms of the amount of chlorophyll in leaves, drought and recovery period maximum type of SPAD value from Eren77 (56.52 and 56.73) while Hilal77 the lowest values were obtained from (52.15 and 52.31). Body weight value of relative dry drought at the end of the implementation of the Doruk77 with the highest being obtained from 33.47 g minimum value has been obtained from Ata77 with 24.35 g. In terms of relative root dry weight, the highest value is being obtained from 24.79 g Doruk77 with the minimum value has been obtained from Dorukhan77 with 18.44 g. Leaf after leaf of the drought in the area measuring growth% 2.57 cultivar Dorukhan77 with, while the lowest leaf growth is cultivar has been Doruk77 0.26%.

Effects of different fresh gas flows and different anesthetics on airway temperature and humidity in surgical patients: a prospective observational study.

This study was aimed to investigate the effects of different fresh gas (oxygen + air) flow rates and different anesthetics on airway temperature and humidity when using the same anesthesia machine in patients undergoing general anesthesia. In this prospective, observational study, 240 patients with American Society of Anesthesiologists (ASA) I–II between the age of 18–65 years to be operated under general anesthesia were enrolled and divided into two groups according to the fresh gas flow rate (3–6 L/min). Each of the two main groups was further divided into three subgroups according to the administered anesthetic gases and drugs. The resulting six groups were further divided into two subgroups according to whether the heat and humidity exchanger filter (HME) was attached to the breathing circuit, and the study was carried out on a total of 12 groups. The temperature and humidity of the inspired air were recorded every 10 minutes using an electronic thermo-hygrometer. The inspired temperature and humidity were greater in patients ventilated at 3 L/min compared to the 6 L/min group and in HME (+) patients compared to HME (–), regardless of the type of anesthetics. HME application makes the air more physiological for the respiratory tract by increasing the temperature and humidity of the air regardless of the anesthetic agent. This study was approved by Ethics Committee Review of Selcuk University Faculty of Medicine (No. 2017/261) in September 2017, and was registered in the Clinical Trial Registry (identifier No. NCT04204746) on December 19, 2019.

Clinical features and outcome of MIS-C patients: an experience from Central Anatolia.

BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a new clinical condition characterized by signs of inflammation and multiorgan dysfunction due to cytokine storm associated with SARS-CoV-2. The clinical spectrum of MIS-C ranges from mild to severe, and even to mortal multisystem involvement. To guide clinicians, we evaluated detailed demographic characteristics, clinical features, laboratory findings, and outcomes of MIS-C cases.MethodsWe performed a retrospective study of patients with MIS-C who were managed in the Department of Pediatric Infectious Disease in the Selcuk University Faculty of Medicine, Konya, Turkey. MIS-C patients were divided into three clinical severity groups (mild, moderate, and severe) and separated into three age groups (< 5 years, 5–10 years, > 10 years). We compared the characteristics of MIS-C cases according to the severity of the disease and by age groups.ResultThirty-six children with MIS-C were evaluated (52.8% male, median age of 7.8 years). A clinical spectrum overlapping with Kawasaki disease (KD) was the most common presentation (69.4%) in all age groups. The most common clinical symptoms were fever (100%), mucocutaneous rash (69.4%), and gastrointestinal symptoms (66.6%). There was no statistically significant difference in echocardiographic abnormality between KD-like and the other clinical spectra (p > 0.05). All life-threatening rhythm disturbances were observed in severe cases. No patients died.ConclusionIt is important to increase the awareness of physicians about the MIS-C disease, which can present with different combinations of different systemic findings, so that patients can be diagnosed and treated in a timely manner. Key Points• A single tertiary centre study shows that children with MIS-C can present with different clinic spectra other than Kawasaki diseases.• Electrocardiographic and echocardiographic evaluation is important in early diagnosis of children with MIS-C.• Pro-BNP can be used as a screening test in the emergency room for children with prolonged and unexplained fever for determine early cardiac involvement of MIS-C.• The lack of require biological agents and favourable outcomes in children with MIS-C may be related with administration of steroid therapy with IVIG in early stage of disease.

Education Experience of Selcuk University Faculty of Medicine During The Covid-19 Pandemic

Selçuk Üniversitesi Tıp Fakültesi 2001 yılında kurulmuş, 2002-2003 eğitim öğretim yılından beri tıp eğitimi vermekte olan ve 2015 yılından itibaren de UTEAK tarafından akredite edilmiş bir tıp fakültesidir. Fakültemiz şu ana kadar 2008-2020 dönemleri arasında toplam 1128 mezun vermiştir. Öğrenci sayımız 2019-2020 eğitim döneminde 1278’dir. Dünyada zaman zaman ortaya çıkan en önemli pandemilerden biri olarak, Çin’in Wuhan kentinde 2019’da ortaya çıkıp bütün dünyaya yayılmaya başlayan COVID-19 hastalığının Dünya Sağlık Örgütü tarafından Mart 2020’de pandemi olarak ilanı ile bütün dünyada eğitim, sağlık, ekonomi ve daha pek çok alanda ciddi değişiklikler yaşanmaya başlamıştır. SARS-CoV2 virüsünün kolay ve hızlı yayılma potansiyeli ve daha ciddi tablolar oluşturuyor olmasından dolayı, başta izolasyon önlemleri olmak üzere ciddi önlemler alınmaya başlamıştır. Eğitim bu epideminin en çok etkilediği alanlardan biri olmuştur. Tıp fakülteleri de bu süreçte uzaktan eğitim programlarına geçmiştir. Fakültemizde de uygulamakta olduğumuz çekirdek eğitim müfredatı korunacak ve COVD 19 Pandemi süreci ile ilgili yeni donanımlar kazandıracak şekilde uygulanmıştır. Sürecin gerektirdiği uzaktan eğitim sistemi teorik ve pratik dersler, ölçme ve değerlendirme süreçlerini de içerecek şekilde yeniden düzenlenmiş ve eğitim tamamlanmıştır. Bu süreçte toplam 952 ders videosu sisteme yüklenmiş ve 56 sınav gerçekleştirilmiştir. TEBDAD önerileri ile ders materyalleri ek döküman ve uygulama videoları ile desteklenmiştir. Yaşadığımız bu dönem eğitimde yeni açılımlar için de yeni alanlarda vizyon geliştirmemizi sağlamıştır. Geleneksel değerleri koruyarak değişen dünya ve koşullar ile birlikte değişme ve gelişme süreci için tıp fakülteleri de yeni hedefler ve vizyonlar geliştirmelidir.

The influence of vaginal progesterone on Uterine Artery Pulsatility Index.

Uterine artery Doppler is frequently used in the first trimester and it is one of the more effective measurement methods in the prediction of preeclampsia and intrauterine growth restriction (IUGR). Progesterone is a hormone that is used quite frequently in various indications in obstetrics and gynecologic practice. We aimed to investigate the influence of progesterone on the uterine artery Doppler pulsatility index (PI) at 11-14 gestational weeks. This study is a retrospective case-control study conducted in Selcuk University Faculty of Medicine between January and December 2019. Uterine artery Doppler PI values of patients using progesterone were compared with PI values of patients not using progesterone. Uterine artery PI was measured two times, left and right. Then the mean PI was calculated. All measurements were made by two operators and by the same ultrasonography machine RESULTS: A total of 288 patients, 140 patients using progesterone and 148 patients not using progesterone were included in the study. Demographic characteristics were similar between the groups (p > 0.05). There were no significant differences between the groups in the right and left uterine artery PI values. There was no significant difference for average uterine artery PI between the groups (p < 0.05). Progesterone has no significant influence on uterine artery PI. However, more prospective studies in which all potential confounding factors are considered including serum progesterone levels are needed for this subject.

COVID-19 Pandemisinde Sağlık Çalışanları ve Tıp Fakültesi Öğrencilerinin El-Yüz Temas Davranışlarının Değerlendirilmesi

Background: Respiratory viruses such as SARS-CoV-2 spread via different transmission routes. While the droplet path plays the most important role in transmisson, contamination of the mucous membranes with contaminated hands also plays an important role in the spread. Thus, the aim of the present study was to assess the face-touching behaviors of HCWs and intern doctors during the COVID-19 pandemic. Methods: This study was conducted in July 2020 and in the Selcuk University Faculty of Medicine in Konya, Turkey. While 1-hour COVID-19 training was given to healthcare personnel and interns, participants face-touching behavior was monitored through video recording and was tallied with a scoring sheet. Results: A total of 141 intern doctors, 46 assistant doctors, 14 nurses, 10 associate doctors, and eight staff members participated in the study. On average, each of the participants touched their face a mean of 17.2 times (median: 16; range: 0–45) per hour. Of all the face touches, 85.2% (3,228/3,787) involved contact with a face mask, whereas 14.7 % (559/3787) involved contact with the eye mucosa. Intern doctors touched their faces significantly less often with a mean of 13.7 times per hour (P &amp;lt; 0.001), while nurses touched their faces more often with a mean of 28 times per hour (P &amp;lt; 0.001). Although nurses touched their eye mucosa more often than interns and assistant doctors (P &amp;lt; 0,001), their contact with the face mask was significantly less frequent than that of the other participants (P &amp;lt; 0.001). Conclusions: To date, there are no effective vaccines or antiviral drugs for SARS-CoV-2. For the time being, isolation, social distancing measures, and individuals’ protective behaviors are essential for preventing infection. HCWs, medical students, and the broader community should be informed about self-inoculation, which can result from touching one’s mucosa or mask with contaminated hands.

Structural determination of the relationship between trait anxiety and personal indecisiveness for undergraduates of the faculty of veterinary medicine: The case of Selçuk University

In this study, it was aimed to determine the relationship between trait anxiety and personal indecisiveness of undergraduate students of the Faculty of Veterinary Medicine. For this purpose, a questionnaire was applied to 244 undergraduate students at Selcuk University Faculty of Veterinary Medicine. Trait anxiety and personal indecisiveness scales were used for this questionnaire. The Cronbach’s Alpha (α) coefficient was calculated as 0.798 for the trait anxiety scale and 0.929 for the personal indecisiveness scale. After the factors were determined by explanatory factor analysis, they were tested by confirmatory factor analysis to test the appropriateness of factor structures. Chi-square test, RMSEA, GFI and CFI fit indices were used in confirmatory factor analysis. For the results obtained from indices of fit, the chi-square test was calculated as 1.621, RMSEA 0.051, GFI 0.851, CFI 0.930. The model obtained according to the fit index values was found to fit well. As a result, there was a correlation between students’ trait anxiety and personal indecisiveness. As a result of our findings, it was revealed that trait anxiety of students affected the decision-making processes. By carrying out similar studies annually within the universities, positive or negative aspects for the personal development of students can be determined, and it can be ensured that they become healthy physicians in the future. The results can give an idea to the managers about decisions concerning some improvements and developments in universities.

Psikoeğitim Programının Üniversite Öğrencilerinin Tükenmişlik Düzeyine Etkisi

The aim of this study is to examine to what extent the psychoeducation program affects the burnout levels of university students. This research is an quasi-experimental study using pretest-posttest design with a control group. The study group consists of 24 students who were studying at Selcuk University Faculty of Health Sciences in the 2018-2019 academic year and volunteering to participate in the group study. Maslach Burnout Inventory-Student Scale (MBI-SS) and Personal Information Form were used as data collection tools in the study. The psychoeducation program for university students has been prepared based on cognitive behavioral therapy approach. A psychoeducation program consisting of 8 sessions, prepared to reduce the burnout levels of university students, was applied to the experimental group for 8 weeks. Two-way analysis of variance and t-test were used for mixed measurements to analyze the data. The analysis results showed that the psychoeducation program was effective in reducing the emotional exhaustion and depersonalization scores of the students in the experimental group.

Sigara İçen ve İçmeyen Yetişkinlerin Ekspiryum Havasındaki Karbonmonoksit Düzeylerinin Bağımlılık Puanları ile İlişkisinin Değerlendirilmesi

Objectıve: Smoking; along with psychological factors and habits, it causes addiction in people. The level of smoking addiction is determined in clinical practices with the Fagerström Test for Nicotine Dependence (FTND). CO level measurement in expiratory air is frequently used today as a biomarker in the diagnosis, treatment and follow-up stages of addiction. In this study, it was aimed to evaluate the relationship between CO levels and FTND of smokers. Materials and Methods: The questionnaire was applied to smokers and healthy volunteers coming to the Selcuk University Faculty of Medicine Family Practice Clinic. 68 smoker patients and 60 non-smoker volunteers were included. Patients' sociodemographic characteristics, age of starting smoking, CO levels in expiratory air and FTND scores were recorded. The relationship between FTND scores and CO levels in expiratory air was investigated. Chi-square test was used to examine the comparison of categorical data. P value p&amp;lt;0,05 was considered statistically significant. Results: The mean age of the individuals included in the scope of the study was 53.0±6.9 and 39.1% of them were women, 60.9% of them were men. There was a statistically significant difference was found between the participants' gender, age, occupational characteristics and marital status and smoking status. FNBT score of smokers was found to be 5.00 ± 2.44 points. The average number of cigarettes smoked/year was 31.00±17.87 years, the average number of cigarettes smoked per day was 20.00±8.76 and the average age to start smoking was 18.00±4.82. There was a positive correlation between the CO results and FTND scores (p≤0.001). There was a negative correlation between the CO results and FEV1/FVC scores(p≤0.001). Conclusıon: Among the scales that measure nicotine addiction level, FTND is the most used one in smoking cessation clinics today. In our study, there was a positive correlation between CO levels and FTND scores, which was found statistically significant. Measuring CO during patient follow-up is both an objective criterion for evaluating smoking cessation and enhances patient compliance. Therefore, CO levels can also be used as a guiding factor in determining the severity of cigarette addiction. Keywords: Addiction, Carbonmonoxide, Smoking.

How does seminal plasma fatty-acid binding protein-9 level change in infertile males?

In recent years, free fatty acid binding proteins (FABPs) are implicated in spermatogenesis and sperm morphology. FABPs are members of the intracellular lipid-binding protein family; they exhibit tissue specific expression like the FABP9/PERF15 (Perforated15) male germ cell-specific fatty acid linkage-protein.The aim of the study was to assess the levels of seminal FABP-9 in normozoospermic and oligozoospermic men, and the possible relations between seminal FABP-9 levels and semen parameters.Research was carried out on 60 male volunteers who were admitted to Selcuk University Faculty of Medicine of Andrology Laboratory. Normozoospermic individuals (n = 30) were identified as Group 1, and Oligozoospermic individuals (n = 30) were identified as Group 2. The semen samples were collected in sterile plastic containers. Sperm parameters were assessed according to Kruger's criteria. Seminal plasma FABP-9 levels were analyzed by ELISA method. Outcomes were statistically evaluated at 0.05 significance level with SPSS (22.0). The Receiver Operating Characteristic (ROC) curve was used to evaluate the performance of FABP-9 levels as compared to that of the concentration and motility data of the sperm. FABP-9 levels were significantly higher in normozoospermic individuals (3.41 ± 1.64 ng/mL) than in oligozoospermic individuals (1.99 ± 0.78 ng/mL). There were significant correlations between FABP-9 levels and sperm concentration, total sperm count, motility, progressive motility, immobility, Total Progressive Motil Sperm Count (TPMSC), head anomaly, and teratozoospermia index.We suggest that FABP-9 level is an important biomarker, and low levels of semen FABP-9 may impact the fertility status based on the ROC findings.

SALÂHÎ’NİN MECMA-İ FENN-İ ZERÂFET ADLI FARSÇA GRAMERİ

Farsça, Osmanlı eğitim sisteminde XV. yüzyıldan başlayarak XX. yüzyılın ikinci çeyreğine kadar ders olarak okutulmuş bir dildir. XV. yüzyılın başlarından itibaren Farsça, tasavvufi düşüncenin gelişimi ve Mesnevî ’nin anlaşılması amacıyla tekkelerde de ders olarak okutulmuştur. Abdullah Salâhaddîn-i Uşşâkî adıyla da tanınan ve Uşşâkiyye tarikatının üçüncü piri olarak bilinen Salâhî, XVIII. yüzyılda Osmanlılar devrinde yaşamış Halvetî-Uşşâkî şeyhlerindendir. Hem Arapçaya hem de Farsçaya hakimiyeti olan âlim, şair ve şarih bir zattır. Salâhî’nin eski kaynaklarda toplamda bugünkünden daha çok eserinin olduğu söylense de günümüzde 12 adet telif eser, 11 adet şerh ve 8 adet tercümesiyle toplamda 31 adet eserinin olduğu bilinmektedir. Osmanlı Türkçesiyle yazılan Mecma-i fenn-i zerâfet , Salâhî’nin Farsça gramer konusunda kaleme aldığı telif eserlerinden biridir. Eser, erken dönemlerde sözlüklerde açıklanan gramer konularının düzenlenerek bir kitapta toplanması ve Arapça yazılan Farsça gramerlerin de anlaşılmasındaki zorluğun giderilmesi amacıyla Osmanlı Türkçesiyle yazılmıştır. Mecma-i fenn-i zerâfet adlı eserde müellifin istifade ettiğini söylediği kaynaklar, kütüphanelerdeki kataloglarda farklı adlarla kaydedilmiş ve eserlerle ilgili bilgiler eksik verilmiştir. Bu makalede, Farsçanın tarihi seyri konusunda kısa bir bilgiden sonra hem Salâhî’nin Mecma-i fenn-i zerâfet adlı eser hem de istifade ettiğini söylediği Kavâid-i Fürs ile Mefâtîh-i deriyye adlı eserlerle ilgili bilgiler verilmiş ve Mecma-i fenn-i zerâfet adlı eser tanıtılmıştır.

Meme Kanseri Olan Hastalarda Serum Homoarjinin ve İskemi Modifiye Albumin Düzeyleri

Objectives: Homoarginine and ischemia modified albumin are among the molecules that are intensely studied on. Homarginine and ischemia-modified albumin levels in breast cancer patients are extremely important in understanding the pathogenesis of diseases, associating these molecules with treatment, developing new treatment protocols, and even eliminating risk factors in healthy people before diseases occur. Our aim in this study is to determine homoarginin and ischemia-modified albumin levels in the serum of breast cancer patients and its relation with the disease. Material and Methods: 27 controls, 27 breast cancer were included in the study. Serum methylarginine and homoarginine levels were studied by mass spectrometric method, and ischemia modified albumin levels by colorimetric method in Selcuk University Faculty of Medicine Biochemistry Laboratory. Results: While the levels of L-monomethylarginine, Total Methyl Arginine, Homoarginine statistically decreased, asymmetric dimethylarginine and ischemia modified albumin levels significantly increased in patients compared to controls (p &lt;0.05). Conclusions: Increased ischemia modified albumin levels may indicate the oxidative stress that occurs in breast cancer. Increase in asymmetric dimethylarginine levels can lead to decreased nitric oxide synthesis and deterioration of the vascular structure. Keywords: Breast cancer; Homoarginine; Ischemia modified albumin; Mass spectrometry

Value Perceptions of National Boxers that Study at Physical Education and Sports Department of Universities

&lt;p&gt;Purpose of this research is to determine the perception of value of national boxers who study in physical education and sports department in universities. The research was evaluated with semi-structured interview method which is one of the qualitative research designs. The research group consisted of 11 national boxers studying at Gazi University Faculty of Sport Sciences, Firat University Faculty of Sport Sciences, Selcuk University Faculty of Sport Sciences and Mustafa Kemal University School of Physical Education and Sports in 2016-2017 academic year. Data were accessed through the Personal Information Form (4 questions) and Semi-Structured Interview Form (3 questions) prepared by the researchers. In the analysis of the data, content analysis method was utilized. As a result, national boxers who received sports science education at universities had value perceptions such as discipline, gentlemanship, self-confidence, respect, cooperation, responsibility, empathy, health, ambition, systematic work, tolerance and protection from bad habits and they also do not tolerate discrimination, violence and doping.&lt;/p&gt;