Meme Kanseri Olan Hastalarda Serum Homoarjinin ve İskemi Modifiye Albumin Düzeyleri

Abstract

Objectives: Homoarginine and ischemia modified albumin are among the molecules that are intensely studied on. Homarginine and ischemia-modified albumin levels in breast cancer patients are extremely important in understanding the pathogenesis of diseases, associating these molecules with treatment, developing new treatment protocols, and even eliminating risk factors in healthy people before diseases occur. Our aim in this study is to determine homoarginin and ischemia-modified albumin levels in the serum of breast cancer patients and its relation with the disease. Material and Methods: 27 controls, 27 breast cancer were included in the study. Serum methylarginine and homoarginine levels were studied by mass spectrometric method, and ischemia modified albumin levels by colorimetric method in Selcuk University Faculty of Medicine Biochemistry Laboratory. Results: While the levels of L-monomethylarginine, Total Methyl Arginine, Homoarginine statistically decreased, asymmetric dimethylarginine and ischemia modified albumin levels significantly increased in patients compared to controls (p <0.05). Conclusions: Increased ischemia modified albumin levels may indicate the oxidative stress that occurs in breast cancer. Increase in asymmetric dimethylarginine levels can lead to decreased nitric oxide synthesis and deterioration of the vascular structure. Keywords: Breast cancer; Homoarginine; Ischemia modified albumin; Mass spectrometry