Earthquake-induced shallow landslides are widely distributed in earthquake-affected areas. These hazards mainly originate from fragmented surface rock masses or surficial loose deposits overlaid on bedrock structure slopes. The seismic response of the surficial soil-bedrock slope is the key to revealing the dynamic failure mechanism of earthquake-induced landslides. This study investigates the seismic response of a surficial soil-bedrock step-like slope to evaluate the acceleration ground motion amplification along the slope. Parametric analysis focusing on the geometry of the surficial soil, thickness of the surficial soil, surficial soil-bedrock impedance contrast and geometry of the slope is conducted using the finite difference modeling code FLAC3D. The results show that both the surficial soil characteristics and geometry of the slope have great influences on the acceleration amplification factor in the horizontal direction (AAF). A maximum AAF zone is always formed near the interface between the surficial soil and bedrock, and the AAF always abruptly amplifies near the slope surface, especially at the crest of the slope. The potential dynamic failure surfaces under earthquakes are formed near the interface between the surficial soil and bedrock, which is in accordance with the AAF amplification zone of the slope, and the depth of the dynamic failure of the surficial bedrock slope is deeper than the static failure surface. It can be concluded that the topographic effect on the seismic response of the slope is strongly dependent on the surficial soil material characteristics and geometry. The findings of this study can contribute to a better understanding of the mechanism of shallow earthquake-induced landslides and have a number of important implications for disaster prevention and mitigation.