Artificial ground freezing (AGF) is used for constructing subway cross passages in coastal areas. The continuous construction of complex projects (cross-sea or cross-river tunnels) has resulted in freezing environments with high groundwater seepage velocities. Seepage cannot provide an open system in soil freezing for moisture migration, resulting in large amount of frost heave owing to segregated ice compared to close freezing system. The influence of frost heave under seepage on the compressive strength of frozen silt during artificial ground freezing must be studied to ensure AGF construction safety. Thus, a unidirectional freezing device that can control seepage and confining pressure conditions during freezing was designed to prepare frozen silt samples under different seepage velocities with confining pressures and to measure the relevant segregation frost heave. Subsequently, uniaxial compression tests were performed. The compressive strength of frozen silt under the influence of frost heave and seepage conditions was analyzed. The frost heave rate, uniaxial compressive strength, and elastic modulus of frozen silt in an open freezing system were measured. The seepage velocity during freezing increased the frost heave rate of the silt; the uniaxial compressive strength and elastic modulus of the frozen silt increased subsequently. The effective confining pressure suppressed frost heave of silt and reduced the uniaxial compressive strength and elastic modulus of the frozen silt. The test results were analyzed considering the segregation frost heave formation mechanism, and a theoretical improvement model of the uniaxial compressive strength and elastic modulus of frozen silt related to the content of segregated ice was proposed. This research is significant for ensuring the AGF construction safety in cross-river or ocean tunnel engineering under seepage conditions.