The integration of blockchain technology in biomedical diagnostics offers a promising solution to the challenges of data security and privacy in infectious disease surveillance. As the digitalization of healthcare systems accelerates, the need to protect sensitive health information becomes increasingly critical. Blockchain, with its decentralized and immutable nature, provides a robust framework for ensuring the integrity and confidentiality of biomedical data. This abstract explores how blockchain technology can be leveraged to enhance data security and privacy in the context of infectious disease surveillance, where rapid and accurate data sharing is essential for effective public health responses. Infectious disease surveillance relies on the collection, analysis, and dissemination of large volumes of data, often shared across multiple institutions and geographical regions. Traditional systems for managing this data are vulnerable to breaches, unauthorized access, and data tampering, which can compromise public health efforts and patient privacy. Blockchain technology addresses these vulnerabilities by enabling secure, transparent, and tamper-proof data exchanges. Each transaction or data entry is recorded in a distributed ledger, accessible only to authorized participants, thus ensuring that the data remains secure and unaltered. Moreover, blockchain’s inherent transparency allows for real-time monitoring and auditing of data flows, which is crucial in the timely detection and response to infectious disease outbreaks. The use of smart contracts within blockchain networks further enhances the automation and efficiency of data management, ensuring that data is only accessed and shared according to predefined rules and conditions. This not only safeguards patient privacy but also builds trust among stakeholders, including patients, healthcare providers, and public health authorities. In conclusion, the integration of blockchain technology in biomedical diagnostics presents a transformative approach to addressing the critical issues of data security and privacy in infectious disease surveillance. By leveraging blockchain's unique features, healthcare systems can ensure that sensitive diagnostic data is protected, thus supporting more effective and secure public health interventions in the fight against infectious diseases. Keywords: One Health Approach, Zoonotic Disease, Early Detection, Development, Portable Diagnostic Device.