The dialogue process between China and ASEAN was officially launched in 1991. Over the past three decades, the bilateral relations between them have made remarkable achievements and become a model of cooperation in the Asia-Pacific region. Since the outbreak of COVID-19, China and ASEAN have developed closer ties and made great progress in cooperation in political security, economic trade, health security and other fields. Today, ASEAN has surpassed the United States and the European Union to become China's largest trading partner. This paper discusses the necessity of cooperation between China and ASEAN in the post-epidemic era. For China, ASEAN is an important strategic pivot to safeguard its neighborhood security. China has always followed an ASEAN-centric strategy, and its vaccine diplomacy during the pandemic has been very effective, which has boosted its relations with ASEAN. For ASEAN, its internal vulnerability has forced it to rely on external powers, with China being one of its preferred powers because of its geographical location and close economic ties. As to global order, the US pivot to Asia and the more serious friction between China and the US during the pandemic era make it necessary for China and ASEAN to work together to maintain the unity of the Asian region.