We explore extensively topological quantum phase transitions (TQPTs) of the breathing kagomé lattice model in the presence of staggered fluxes. We obtain rich topological phases, including the Chern insulator (CI) and the second-order topological insulator (SOTI) phases, by tuning the dimerized hopping parameter t 1′ and the staggered-flux parameter ϕ. The CI phases can be identified on the basis of the chiral edge states and the non-zero Chern numbers. However, in sharp contrast to the CI phases, the SOTI phases are characterized by the robust corner states and the quantized polarizations. In addition, we explore the TQPTs considering the next-nearest-neighbor hopping parameter t 2. We demonstrate the existence of two-dimensional SOTIs with broken time-reversal symmetry and reveal the TQPTs between the CIs and the SOTIs.