Secondary Processes Research Articles

Phytoremediation of Cr(VI)-rich wastewater using Water Hyacinth, Water Lettuce and Duckweed

Chromium(VI) contamination is carcinogenic and largely anthropogenic, stemming from specific industries. With Bangladesh experiencing rapid industrialization, the increasing number of industries necessitates an economic and sustainable secondary treatment process to maintain acceptable chromium levels. Phytoremediation, an environmentally friendly biochemical technique, has been extensively researched, particularly in the context of constructed wetlands. However, due to land scarcity and legal issues a constructed wetland is not the most viable option. In this study, three native aquatic plants—Eichhornia crassipes (Water Hyacinth), Pistia stratiotes (Water Lettuce), and Lemna minor (Duckweed)—were chosen to evaluate their effectiveness in removing chromium from wastewater. These plants underwent testing with five different chromium concentrations (1 mg/L, 2 mg/L, 3 mg/L, 4 mg/L, 5 mg/L) and two pH values (6 and 8) using natural ditch water as the feed solution. All the experiments were performed for 7 days in duplicate, along with a control experiment of chromium without plants. The study was conducted at Shahjalal University of Science and Technology campus, Bangladesh, from May 25 to June 1, 2023. Atomic Absorption Spectrometer was employed to measure Cr(VI) concentration, revealing average chromium removal rates of 29.4%, 81.1%, and 81.5% for Eichhornia crassipes, Pistia stratiotes, and Lemna minor, respectively, after seven days. Notably, on day three, Lemna minor exhibited the highest average removal efficiency at 84.7%.

Mixing Order Asymmetry in Nanoparticle-Polymer Complexation and Precipitation Revealed by Isothermal Titration Calorimetry.

In recent years, there has been a renewed interest in complex coacervation, driven by concerted efforts to offer novel experimental and theoretical insights into electrostatic charge-induced association. While previous studies have primarily focused on polyelectrolytes, proteins, or surfactants, our work explores the potential of using cerium (CeO2) and iron (γ-Fe2O3) oxide nanoparticles (NPs) to develop innovative nanomaterials. By combining various charged species, such as polyelectrolytes, charged neutral block copolymers, and coated NPs, we study a wide variety of complexation patterns and compare them using isothermal titration calorimetry, light scattering, and microscopy. These techniques confirm that the titration of oppositely charged species occurs in two steps: the formation of polyelectrolyte complexes and subsequent phase (or microphase) separation, depending on the system studied. Across all examined cases, the entropic contribution to the total free energy surpasses the enthalpic contribution, in agreement with counterion release mechanisms. Furthermore, our investigation reveals a consistent asymmetry in the reaction enthalpy associated with the secondary process, with exothermic profiles observed upon the addition of cationic species to anionic ones and endothermic profiles in the reverse case.

Evidence for faulting and fluid-driven earthquake processes from seismic attenuation variations beneath metropolitan Los Angeles

Seismicity in the Los Angeles metropolitan area has been primarily attributed to the regional stress loading. Below the urban areas, earthquake sequences have occurred over time showing migration off the faults and providing evidence that secondary processes may be involved in their evolution. Combining high-frequency seismic attenuation with other geophysical observations is a powerful tool for understanding which Earth properties distinguish regions with ongoing seismicity. We develop the first high-resolution 3D seismic attenuation models across the region east of downtown Los Angeles using 5,600 three-component seismograms from local earthquakes recorded by a dense seismic array. We present frequency-dependent peak delay and coda-attenuation tomography as proxies for seismic scattering and absorption, respectively. The scattering models show high sensitivity to the seismicity along some of the major faults, such as the Cucamonga fault and the San Jacinto fault zone, while a channel of low scattering in the basement extends from near the San Andreas fault westward. In the vicinity of the Fontana seismic sequence, high absorption, low scattering, and seismicity migration across a fault network suggest fluid-driven processes. Our attenuation and fault network imaging characterize near-fault zones and rock-fluid properties beneath the study area for future improvements in seismic hazard evaluation.

Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice

Traumatic brain injury (TBI) is characterized by complex secondary injury processes involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible therapeutic target. However, the pathogenic role of the p75NTR co-receptor sortilin in TBI has not been investigated. In this study, we examined whether sortilin contributes to acute and early processes of secondary injury using a murine controlled cortical impact (CCI) model of TBI. Initial expression analysis showed a down-regulation of sortilin mRNA levels 1 and 5 day post injury (dpi) and a reduced expression of sortilin protein 1 dpi. Next, a total of 40 SortilinΔExon14 loss-of-function mouse mutants (Sort1−/−) and wild-type (Sort1+/+) littermate mice were subjected to CCI and examined at 1 and 5 dpi. Neither sensorimotor deficits or brain lesion size nor CCI-induced cell death or calcium-dependent excitotoxicity as evaluated by TUNEL staining or Western blot analysis of alpha II spectrin breakdown products were different between Sort1−/− and Sort1+/+ mice. In addition, CCI induced the up-regulation of pro-inflammatory marker mRNA expression (Il6, Tnfa, Aif1, and Gfap) irrespectively of the genotype. Similarly, the mRNA expressions of neurotrophins (Bdnf, Ngf, Nt3), VPS10P domain receptors others than sortilin (Ngfr, Sorl1, Sorcs2), and the sortilin interactor progranulin were not affected by genotype. Our results suggest that sortilin is a modulatory rather than a critical factor in the acute and early brain tissue response after TBI.

Experimental Constraints on the Origin of the Lunar High‐Ti Basalts

AbstractHigh‐pressure and high‐temperature experiments were conducted to simulate melting of a hybrid cumulate lunar mantle. The experimental results show that intermediate to high‐Ti lunar pyroclastic glasses (>6 wt% TiO2) can be produced by partial melting of lunar cumulates. High‐Ti basalts are generated when the ilmenite/clinopyroxene ratios in the lunar mantle cumulates are between 1/1 and 4/1, depending on the degree of melting. The presence of an urKREEP component in the mantle cumulate strongly influences Al2O3/CaO of the melts. The experiments provide strong evidence for the model that the compositional diversity of lunar basalts is a consequence of a gravitational overturn of the lunar interior after the lunar magma ocean had solidified. Ilmenite/clinopyroxene in the cumulate mantle, which generates high‐Ti melts at partial melting, do not comprise the ratios in ilmenite‐bearing cumulates (IBC), which crystallized after ∼90% solidification of the lunar magma ocean and indicate local accumulation of ilmenite in the overturned lunar mantle. However, to fully match the natural composition of the most primitive lunar samples, secondary processes such as assimilation are still required.

Integrated analysis of transcriptomics and defense-related phytohormones to discover hub genes conferring maize Gibberella ear rot caused by Fusarium Graminearum

BackgroundGibberella ear rot (GER) is one of the most devastating diseases in maize growing areas, which directly reduces grain yield and quality. However, the underlying defense response of maize to pathogens infection is largely unknown.ResultsTo gain a comprehensive understanding of the defense response in GER resistance, two contrasting inbred lines ‘Nov-82’ and ‘H10’ were used to explore transcriptomic profiles and defense-related phytohormonal alterations during Fusarium graminearum infection. Transcriptomic analysis revealed 4,417 and 4,313 differentially expressed genes (DEGs) from the Nov-82 and H10, respectively, and 647 common DEGs between the two lines. More DEGs were obviously enriched in phenylpropanoid biosynthesis, secondary metabolites biosynthesis, metabolic process and defense-related pathways. In addition, the concentration of the defense-related phytohormones, jasmonates (JAs) and salicylates (SAs), was greatly induced after the pathogen infection. The level of JAs in H10 was more higher than in Nov-82, whereas an opposite pattern for the SA between the both lines. Integrated analysis of the DEGs and the phytohormones revealed five vital modules based on co-expression network analysis according to their correlation. A total of 12 hub genes encoding fatty acid desaturase, subtilisin-like protease, ethylene-responsive transcription factor, 1-aminocyclopropane-1-carboxylate oxidase, and sugar transport protein were captured from the key modules, indicating that these genes might play unique roles in response to pathogen infection,ConclusionsOverall, our results indicate that large number DEGs related to plant disease resistance and different alteration of defensive phytohormones were activated during F. graminearum infection, providing new insight into the defense response against pathogen invasion, in addition to the identified hub genes that can be further investigated for enhancing maize GER resistance.

Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep.

Domestic animals have multiple phenotypes of skin and coat color, which arise from different genes and their products, such as proteins and metabolites responsible with melanin deposition. However, the complex regulatory network of melanin synthesis remains to be fully unraveled. Here, the skin and tongue tissues of Liangshan black sheep (black group) and Liangshan semi-fine-wool sheep (pink group) were collected, stained with hematoxylin-eosin (HE) and Masson-Fontana, and the transcriptomic and metabolomic data were further analyzed. We found a large deposit of melanin granules in the epidermis of the black skin and tongue. Transcriptome and metabolome analysis identified 744 differentially expressed genes (DEGs) and 443 differentially expressed metabolites (DEMs) between the pink and black groups. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses revealed the DEGs and DEMs were mainly enriched in the pathways of secondary metabolic processes, melanin biosynthesis processes, melanin metabolism processes, melanosome membranes, pigment granule membranes, melanosome, tyrosine metabolism, and melanogenesis. Notably, we revealed the gene ENSARG00020006042 may be a family member of YWHAs and involved in regulating melanin deposition. Furthermore, several essential genes (TYR, TYRP1, DCT, PMEL, MLANA, SLC45A2) were significantly associated with metabolite prostaglandins and compounds involved in sheep pigmentation. These findings provide new evidence of the strong correlation between prostaglandins and related compounds and key genes that regulate sheep melanin synthesis, furthering our understanding of the regulatory mechanisms and molecular breeding of pigmentation in sheep.

Pursuing the circularity of wind turbine blades: Thermochemical recycling by pyrolysis and recovery of valuable resources

Wind turbine blades (WTBs) are the primary waste generated by the wind energy industry and represent one of the major challenges associated with renewable energy from a disposal perspective. Therefore, it is necessary to develop recycling processes to address this environmental issue as circular economy strategies are implemented. This work investigates the technical feasibility of a combined thermochemical process to recover high-quality glass fibers from WTBs while optimizing the composition of the liquid and gaseous fractions. For this purpose, a thermal pyrolysis process in the range of 450–500 °C was studied in a laboratory-scale fixed-bed reactor, followed by thermal cracking of the vapors between 300 and 700 °C. The fixed bed reactor in which the pyrolysis was performed was also used to study a secondary thermochemical process under oxidizing conditions in order to remove residual exogenous organic compounds from the recovered fibers (RFs). For the sake of comparison, a muffle furnace was also used in this second stage. The results indicate that high yields of RFs can be recovered (75.8–77.5 wt%) and, depending on the temperature used in the cracking reactor, either valuable gas (up to 12.9 wt%) or phenol-rich oils (in the range of 8.8–18.7 wt%) can be produced. In addition, carbonaceous compounds can be completely cleaned of RFs after an oxidation process in the same pyrolysis unit, providing a highly versatile process. As an additional advantage, it is observed that after oxidation the RFs are functionalized. This work aims at creating a resource-efficient circular economy, specifically for waste generated from end-of-life renewable energy technologies such as wind turbines.

Uji Bioaktivitas Fraksi Etanol Ekstrak Kulit Buah Jeruk Purut Citrus hystrix Sebagai Anti Bakteri Staphilococus aureus dan Escherecia coli

Plants have several ways to protect themselves from bacteria, one of which is by producing compounds that are toxic or repellent to bacteria. Compounds produced by plants are known as secondary metabolite compounds which originate from secondary metabolic processes. Several secondary metabolite compounds such as flavonoids, alkaloids, saponins, tannins, steroids and terpenoids are currently widely used as antibacterials. One of the plants that has the potential to be developed as a herbal medicine is kaffir lime leaves. Citrus hystrix is ​​the part of the plant most often used by the public. Both for cooking and traditional medicine purposes. In this research, it is hoped that lime peel extract can act as an antibacterial for Escherichia coli and staphylococcus aereus, so that it can be used as a herbal plant for diseases caused by these two bacteria. In the research, the concentrations used for each test bacteria were 50%; 25%; 12.5%. in observing S. aureus bacteria 1x24 hours with a concentration of 50%, the size of the inhibitory zone was 16 mm, the 25% concentration was 11 mm and the 12.5% ​​concentration was 9 mm. Meanwhile, E. Coli bacteria did not show any reaction to the heruk peel extract.

Horizontal Transverse Isotropy Studied Using Tools for Full-Azimuth Seismic Data Processing and an Advanced Well Logging Complex on the Example of Famennian Deposits of the Yugomashevskoye Field

Abstract —This paper presents a solution to the problem of searching for cavernous fractured zones and the zones that determine reservoir heterogeneity in Famennian deposits of one of the licensed sections of the Republic of Bashkortostan. The use of an integrated approach to the study of azimuthal horizontal-transverse isotropy of rocks using wellbore data and modern methods for processing areal seismic data for carbonate deposits associated with the development of organogenic structures is described. The results of using the full-azimuth angular migration technology are obtained. The introduction of high-tech approaches at the research site using full-azimuth seismic data processing, spectral decomposition, AVA/AVAZ inversion, and complex analysis of dynamic properties of the wave field in conjunction with well logging and core data makes it possible to identify the distorted zones of the carbonate reservoir associated with changes in the characteristics of the rock skeleton, the presence of a porous-cavernous-fracture void space and lithological replacement zones, as well as secondary processes, thereby reducing the risks associated with subsequent production drilling.

Effect of Voltage-Gated K+ Channel Inhibition by 4-aminopyridine in Spinal Cord Injury Recovery in Zebrafish.

Spinal cord injury (SCI) affects between 250,000 to 500,000 individuals annually. After the initial injury, a delayed secondary cascade of cellular responses occurs causing progressive degeneration and permanent disability. One part of this secondary process is disturbance of ionic homeostasis. The K+ channel blocker, 4-aminopyridine (4-AP), is used clinically to alleviate symptoms of multiple sclerosis (MS). Several ongoing studies are being conducted to explore additional areas where 4-AP may have an effect, including stroke, traumatic brain injury, and nervous system recovery after SCI. The goal of our study was to determine whether 4-AP affects recovery from SCI in zebrafish (Danio rerio). Using the transgenic line Tg(gfap:EGFP), we created a spinal transection and tracked swim recovery. We found that constant treatment with 10 μM 4-AP increases swimming distance 40%. Live imaging demonstrated that treatment with 4-AP increases radial glial cells bridging at the site of injury in the presence of 4-AP. We conclude that 10 μM 4-AP is pro-regenerative after SCI.

Effect of momentum flow ratio on entrainment of a confined coaxial jet in a co-flow

Iron ore pellet production processes produce large amounts of CO2 emissions when burning fossil fuels. One example is the grate-kiln process, where normally a coal flame is used to indurate pellets. To mitigate the emissions, coal used in rotary kilns can be replaced with for example hydrogen. However, the fuel is mixed with secondary process air, and replacing a solid fuel with a gaseous one changes the mixing characteristics. This demands different means of injecting the fuel. A coaxial jet can be used to control the mixing of fuel and secondary air, as well as the flow field. The aim is to control the mixing of hydrogen and secondary air to achieve a hydrogen flame that is similar to the reference coal flame. This study numerically investigates different coaxial jet configurations. Steady-state simulations of a simplified model of the real kiln are performed using a Reynolds Stress turbulence model. Results show that decreasing the momentum flow ratio between the outer and inner jet, M jet , to a certain value delays the spread of the hydrogen jet and thus gives a longer jet. Further decreasing this ratio gives an even longer jet, but has the side effect of producing recirculation of hydrogen.

Random Forests Regression and Rescoring Strategy for Identifying Inhibitors of Ubiquitin Specific Protease-7

Ubiquitin-specific protease-7 (USP7) is a potential target for cancer therapy. In this work, the evaluation and design of USP7 inhibitors are conducted employing a comprehensive computational approach. Initially, a large database of compounds undergoes preliminary screening via similarity and pharmacophore analyses. Subsequently, a secondary selection process is executed based on both quantitative structure–activity relationship modeling and molecular docking. The final selection is refined through rescoring treatments via consensus scores and MM/GBSA binding free energy. A total of 138 experimental USP7 inhibitors were collected for the construction of random forest regression models using four different feature selection methods. 17 top experimentally active inhibitors were used as models in similarity searching, and eight representative USP7-ligand binding models were used in pharmacophore screening, performed over a database of 14 million compounds. The rescoring approach applied in this study offers an alternative and beneficial method for the ranking and selection of desired molecules. Based on the molecular scaffolds of the highly active inhibitors, some new derivatives have been designed and received high predicted scores for inhibition.

TECHNOLOGICAL COMPLICATIONS (FORMATION DAMAGE) DURING CO2 INJECTION FOR ENHANCED OIL RECOVERY. Part 1. GEOCHEMICAL PROCESSES INVOLVING ROCK MINERALS, CHANGE OF PETROPHYSICAL AND GEOMECHANICAL ROCK PROPERTIES

Decrease in permeability, porosity, change in wettability of oil-bearing formations during field development are defined by a general term - formation damage, which occur at various stages of field development, including drilling, production, application of enhanced oil recovery methods, well stimulation technologies with acid compositions, hydraulic fracturing and well workover. Reservoir damage leads to a reduction in the oil and gas content of reservoirs and in the economic efficiency of operation. In this regard, it is important to understand and prevent formation damage based on experimental and analytical methods, the applicationof which will minimize damage to the oil and gas bearing reservoir. The review considers anthropogenic processes that cause damage to oil and gas reservoir when CO2 is injected by various methods to enhance oil recovery. The processes of interaction of CO2 with formation rock are considered in detail. The main geochemical transformations of rock minerals are given, which lead to changes in the structure of pore space, permeability and porosity, decrease of geomechanical properties. Secondary sedimentation processes and risks of rock particles removal into the borehole are discussed.

Refugee agency in secondary mobility decision-making: a systematic literature review

Decisions made by millions of refugees about where to go, how to make a living and how to secure a future are fundamental drivers of secondary movements. While a substantial body of literature addresses factors contributing to migrants’ decision-making, a comprehensive understanding of the central role of refugees in secondary mobility decision-making, including agency and strategies employed, remains underexplored. This is partly due to the belief that refugees are constrained by external and structural factors and cannot exercise agency, which we challenge. This article provides a systematic analysis of the literature on refugees’ secondary mobility decision-making processes. Using a systematic literature review (SLR) methodology, it presents an in-depth analysis of 40 peer-reviewed, English-language research articles selected from the Web of Science and Scopus databases published before September 2022. The article critically examines the drivers, prevailing dichotomies and conceptual frameworks surrounding refugee categorization, agency, and mobility. By synthesizing a wide range of literature, our paper presents emerging alternative concepts and frameworks that shed light on the complex dynamics of decision-making.

Relevance and regulation of alternative splicing in plant secondary metabolism: current understanding and future directions.

The secondary metabolism of plants is an essential life process enabling organisms to navigate various stages of plant development and cope with ever-changing environmental stresses. Secondary metabolites, abundantly found in nature, possess significant medicinal value. Among the regulatory mechanisms governing these metabolic processes, alternative splicing stands out as a widely observed post-transcriptional mechanism present in multicellular organisms. It facilitates the generation of multiple mRNA transcripts from a single gene by selecting different splicing sites. Selective splicing events in plants are widely induced by various signals, including external environmental stress and hormone signals. These events ultimately regulate the secondary metabolic processes and the accumulation of essential secondary metabolites in plants by influencing the synthesis of primary metabolites, hormone metabolism, biomass accumulation, and capillary density. Simultaneously, alternative splicing plays a crucial role in enhancing protein diversity and the abundance of the transcriptome. This paper provides a summary of the factors inducing alternative splicing events in plants and systematically describes the progress in regulating alternative splicing with respect to different secondary metabolites, including terpenoid, phenolic compounds, and nitrogen-containing compounds. Such elucidation offers critical foundational insights for understanding the role of alternative splicing in regulating plant metabolism and presents novel avenues and perspectives for bioengineering.

Amelioration of salt‐affected soil using combined amendments for synergistic effects: Impacts and management implications

AbstractSaline acid sulphate soils are commonly ameliorated using traditional amendments like lime and cow manure. Biochar, derived from crop residues, is another potential remedy for this type of soil. Their combined use may create synergistic effects, necessitating further investigation. This study aims to assess the combined impacts of biochar with traditional amendments on soil quality, properties and rice yield. A field experiment was established with six treatments: no‐amendment (control), lime, cow manure, biochar, combined lime and biochar, and combined cow manure and biochar with rice (Oryza sativa) planted in four replicates. The study revealed that the effects of these amendments on soil properties were driven by their inherent characteristics and secondary processes, such as neutralization. Combining biochar with lime significantly increased soil pH (6.2), and exchangeable calcium (648.6 cmol(+) kg−1), while reducing exchangeable aluminium (11.83 cmol(+) kg−1) and iron (37.5 cmol(+) kg−1), compared to the control. Meanwhile, combining biochar with cow manure notably enhanced Mehlich‐1 phosphorous (3.4 mg kg−1), organic carbon (4.99%), ammonium (27.0 mg kg−1) and cation exchange capacity (17.2 cmol(+) kg−1). Biochar combined with cow manure exhibited greater synergetic effects on soil quality than when combined with lime. Consequently, these combinations improved the soil quality index, which exhibited a strong correlation with rice yield and biomass when its value was below 0.4. This finding indicates that these combinations exhibit insignificant synergistic effects on rice yield and growth. Further research is needed to elucidate these findings and explore the optimal application rates concerning soil properties for improved management practices.

Quantitative phosphoproteomics reveals molecular pathway network in wheat resistance to stripe rust

Protein phosphorylation plays an important role in immune signaling transduction in plant resistance to pathogens. Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), severely devastates wheat production. Nonetheless, the molecular mechanism of wheat resistance to stripe rust remains limited. In this study, quantitative phosphoproteomics was employed to investigate the protein phosphorylation changes in wheat challenged by Pst. A total of 1537 and 2470 differentially accumulated phosphoproteins (DAPs) were identified from four early infection stage (6, 12, 18 and 24 h post-inoculation) in incompatible and compatible wheat-Pst interactions respectively. KEGG analysis revealed that Oxidative Phosphorylation, Phosphatidylinositol Signaling, and MAPK signaling processes are distinctively enriched in incompatible interaction, while Biosynthesis of secondary metabolites and RNA degradation process were significantly enriched in compatible interactions. In particular, abundant changes in phosphorylation levels of chloroplast proteins were identified, suggesting the regulatory role of photosynthesis in wheat-Pst interaction, which is further emphasized by protein-protein interaction (PPI) network analysis. Motif-x analysis identified [xxxxSPxxxx] motif, likely phosphorylation sites for defensive response-related kinases, and a new [xxxxSSxxxx] motif significantly enriched in incompatible interaction. The results shed light on the early phosphorylation events contributing to wheat resistance against Pst. Moreover, our study demonstrated that the phosphorylation levels of Nucleoside diphosphate kinase TaNAPK1 are upregulated at 12 hpi with CYR23 and at 24 hpi with CYR31. Transient silencing of TaNAPK1 was able to attenuate wheat resistance to CYR23 and CYR31. Our study provides new insights into the mechanisms underlying Pst-wheat interactions and may provide database to find potential targets for the development of new resistant varieties.

Radical socialization? Analysis of the secondary socialization process in the table tennis environment

The article is devoted to the analysis of the secondary socialization process in the table tennis environment. Sports communities represent a specific case study in this context because the secondary socialization processes occurring in them seem more radical. The sports environment is characterized by highly specific features and values conveyed, and interest in this phenomenon may be heightened because sports are a relatively less studied area in terms of their socialization impact on individuals. The main goal of the text is to analyse the specificity of the table tennis environment as a secondary socialization environment. More specific goals include issues related to the specific bonds and relationships formed in such an environment, the specific communication system (slang and characteristic meanings), and the impact of the sports environment on the relations of table tennis players with the world outside of sports. The qualitative analysis allowed for discovering unique patterns that characterize the socialization process in the sports environment. Among these patterns is the blurring of boundaries between values acquired in the sports environment and the external world, as the respondents transferred sports principles to everyday life practices. The totality of socialization in the sports environment also influences the formation of a specific “socialization bubble” and problems in establishing relationships with people not belonging to the sports world: the sports environment became, for many respondents, a reality in itself, generating bonds, rules, and communication patterns for its participants.

Oil-and-gas potential of the northeast Predpatom trough

This article discusses the geological structure and prospects of the oil and gas potential in the northeastern part of the Predpatom trough. The materials of the study included geological findings from deep drilling and data from direct geochemical studies conducted in recent years. It describes the specific features of the structural plans of the upper versus the lower part of the geological cross-section. It is assumed that deep drilling in the area of the Ulugur structure has not reached the target productive horizons in the autochthonous part of the section. After acquiring more recent seismic data, there is a proposal to drill a deeper exploratory well in the area. As another priority target for oil and gas exploration, a potential zone of Vendian clastic deposits wedging on the southwestern slope of the Suntar uplift has been identified. A forecast has been made for the distribution of lithological traps stacked with well-sorted granular Vendian reservoirs in the northern parts of the Ergedzheysky and Ulugursky license areas. In the allochthonous part of the section, the potential for oil and gas content in carbonate deposits from the Vendian and Lower Cambrian periods is highlighted in reservoirs formed by secondary processes. It is assumed that thrust deformations could lead to the circulation of aggressive solutions, resulting in the formation of secondary fractured cavernous reservoirs. Subsequently, hydrocarbon accumulations may migrate and accumulate within these reservoirs. Good gas prospects were also noted in the upper part of the section, where gas deposits were confirmed in newly discovered fields. The results of direct geochemical testing of the Ulugur and Ergedzheysky license areas are presented, enabling the preliminary delineation of promising zones and areas in the studied territory. At the same time, narrow elongated geochemical anomalies are associated with the prospects of the allochthonous part of the section, while isometric anomalies are linked to the autochthonous part of the section. The need to consolidate all available geological and geophysical information on the Pre-Atomic deflection within the framework of case studies is noted.