The Albian-Santonian interval (∼113–83 Ma) is a key interval for Cretaceous climatic and environmental changes. This interval is associated to a rise in sea level until the Late Cenomanian (∼ 94 Ma) and to a progressive increase in oceanic temperatures, leading to consider the Late Cenomanian-Santonian interval (∼ 94–83 Ma) as the warmest period of the last 200 Myr. While the Albian-Santonian interval has been well studied in the Northern Hemisphere, the climatic and environmental variations and their consequences on weathering conditions are less documented of the Southern Hemisphere, especially in mid and high latitudes. To better understanding the evolution of weathering conditions, associated to continental climate and sea level changes during this key period, an integrated study, based on a coupled mineralogical and geochemical approach, was carried out on the clay-sized (< 2 μm) fraction from sediments of International Ocean Discovery Program Site U1513 (Mentelle Basin, South-western Australia) and Oceanic Drilling Program Site 763 (Carnarvon Basin, North-western Australia). To determinate variations in weathering conditions, the mineral assemblages of the clay fraction was determined by X-ray diffraction and observed for selected samples by electron microscopy. To identify sources of clay minerals, the concentrations of major and selected trace elements, including rare earth elements, together with strontium and neodymium isotopic measurements were performed on the clay-sized fraction. The X-ray diffraction analyses reveal that clay fraction is dominated by R0-type illite/smectite mixed-layers (smectites), followed by variable proportions of illites, kaolinites for both sites and only on Site 763 of palygorskites. These clay minerals are associated with opal and clinoptilolites. Electron microscopy observations have highlighted the dominance of detrital fleecy smectites but also the occurrence of recrystallized lathed smectites and volcanogenic folded smectites for Site U1513, and authigenesis of clay minerals, associated to palygorskites especially on Turonian to Santonian deposits for Site 763. This authigenesis, confirmed by negative cerium anomaly, is also carried by other minerals in the clay-sized fraction (e.g., clinoptilolites, barite). These different authigenic minerals record a seawater-derived isotopic signature. Therefore, isotopic compositions of the clay-sized fraction reflect a mix between a continental contribution, carried by detrital clay minerals and marine one, supported by authigenic minerals, which complicates the identification of sediment sources. However, despite this, our study demonstrates the major influence of sea level variations on mineralogical variations from Albian to Cenomanian in Western margin of Australia. The decrease in kaolinite proportions at Site U1513 from the Albian to the end of the Cenomanian, is probably related to the increase of sea level, which cause a decrease in detrital inputs in the Mentelle Basin associated with a decrease of weathering and drainage conditions. The progressive sea level rise has also enhanced the effect of the differential settling process of clay minerals by the deposition of coarse clays (e.g., kaolinites and illites) on the continental shelf. Kaolinite-bearing clay deposits, derived from the weathering of the Western Australian Craton during the Albian-Cenomanian times, have been progressively substituted from the Turonian by a carbonate sedimentation, for which the terrigenous component consists only of rare detrital and volcanogenic smectites. In Site 763, the occurrence in kaolinite content during the Coniacian would indicate a decrease of differential settling process related to the weathering of the north part of the Western Australia Craton.