This article hypothesizes that production and preservation of source-rock type facies in deltaic systems, both landward and seaward of a coastline, is mutually exclusive, time-successive and related to the dynamics of relative sea level. Sedimentologic research in the Holocene Mississippi and Rhône delta complexes suggests that rheotrophic peats and associated organic-rich beds preferably accumulate in the accommodation space created behind landward stepping shorelines in a transgressive systems tract (TST). Such a setting also allows for a sufficient supply of recharging fresh nutrient-rich groundwater into the peat forming mires [Kosters, E.C., Suter, J.R., 1993. Facies relationships and systems tracts in the late Holocene Mississippi Delta Plain. Journal of Sedimentary Petrology 63 (4) 727–733.]. Independently carried-out quantitative paleoecological studies in the same delta systems (and in addition in the Orinoco and Po deltas) suggest that in a progradational setting (highstand systems tract/HST), seasonally discharged nutrient- and sediment-laden river waters on the shelf may give rise to anoxia or dysoxia. Subsequent overfertilization of the shelf leads to accumulation of organic-rich mud belts on the shelf [VanderZwaan, G.J., Jorissen, F.J., 1991. Biofacial patterns in river-induced anoxia. In: Tyson, R.V., Pearson, T.H. (Eds.), Modern and Ancient Continental Shelf Anoxia. Geological Society of London, Special Publication no. 58, pp. 65–82.]. Thus, production and preservation of source-rock type facies landward of a shoreline (as peats and related sediments) is preferred in a TST, when accommodation space and nutrient supply are landward of the shoreline. Vice versa, production and preservation of such facies seaward of a shoreline (as organic-rich shelf muds) occurs preferentially in a highstand systems tract. In that situation, accommodation space is on the shelf, where river-fed nutrients are supplied as well. This hypothesis suggests further potential for application of sequence stratigraphic concepts for improved understanding of the occurrence of source-rock type facies.