The subject of the study: mission-oriented policy in the field of science, technology and innovation, to achieve the SDGs in Ukraine. Purpose: defining the STI policy missions (priority directions) to respond to societal challenges and SDGs; developing the roadmaps for STI policy missions as a tool ensuring their coordination with strategic documents’ measures regarding the SDGs achieving. Methods: policy analysis, foresight research, statistical and scientific-metric analysis, business and information analytics. Results of the work: The objectives of six policy missions in the STI field were determined based on the foresight study, analysis of challenges, scientific and technological potential and stakeholder consultations. For the first time, six STI for SDGs roadmaps were developed for six concrete missions according to a single structure, which includes the situation and trends analysis in the relative sectors, scientific and technological and entrepreneurial potential, the key strategic documents’ measures for the SDGs implementation. The road map content has been agreed with 17 interested authorities. A comprehensive STI for SDGs roadmap has been developed as a toolkit for coordinating regulatory, organizational and financial measures regarding SDGs in Ukrainian strategic documents with the STI policy tools. The research results are the basis for determining the priority directions for the development of science and innovative activities for 2023, approved by the resolutions of the Cabinet of Ministers of Ukraine No. 283 of March 30, 2023 and No. 463 of May 9, 2023. Scope of application of the results: legal regulation in the STI field, transformational innovation policy. Conclusions. Defining the tasks of six policy missions in the field of STI to respond to national challenges and SDGs allowed for a more thorough analysis of the problems and risks of not achieving the SDGs and their relations with the strategic policy planning in the relevant sectors. The mission-oriented STI for SDGs road map becomes a more effective tool for coordinating the priority directions (missions) of the STI policy with measures for their implementation in strategic development documents. Further research will be aimed at strengthening the roadmap’ coordinating role during the implementation of STI policy measures and tools in the sectors of the national economy, as well as developing the appropriate indicators for monitoring and evaluating the progress in the STI for SDGs roadmap implementation.