Screening For Anemia Research Articles

Prevalence and predictors of anemia among six-week-old infants in Kwale County, Kenya: A cross-sectional study.

Anemia is a significant public health problem among children worldwide. The etiology of anemia is multifactorial but iron deficiency (ID) is the most common cause of anemia in low- and middle-income countries. ID and anemia in infancy can impair growth and cognitive development. The aim of this study was to determine the prevalence and predictors of anemia among six-week-old infants in Kwale County, Kenya. This cross-sectional study included 424 mother-infant pairs. Structured questionnaires were administered to the mothers to obtain information on socio-demographic variables, maternal characteristics and birth information. Anthropometric data was collected for each child. A heel prick was done to measure hemoglobin and zinc protoporphyrin concentration levels. Chi-square test, bivariate and multivariate regression analyses were done to determine factors associated with anemia. The prevalence of ID, anemia and IDA was 60.4% (95%CI: 55.9-65.2), 21.0% (95%CI: 17.5-25.2) and 15.8% (95%CI: 12.7-19.7) respectively. Bivariate analysis showed that the risk of anemia was significantly higher among male infants (odds ratio (OR) = 2.20 (95%CI: 1.33-3.63), p = 0.002), iron deficient infants (OR = 2.35 (95%CI: 1.39-3.99), p = 0.001) and infants from Msambweni Sub-County (OR = 2.80 (95%CI: 1.40-4.62), p<0.001). Multivariate analysis revealed that odds of anemia were significantly higher in infants born to mothers who did not use iron supplements during pregnancy (adjusted odds ratio (aOR) = 74.01 (95%CI: 2.45-2238.21), p = 0.013 and significantly lower in infants born to mothers with parity ≥ 4 (aOR = 0.05 ((95%CI: 0.00-0.77), p = 0.024). In six-week-old infants in rural Kenya, anemia prevalence was 21.0% with ID accounting for 75.3% of anemia cases. Given the physical and cognitive impairments associated with ID and anemia in early infancy, it may be prudent to re-evaluate the current Kenyan pediatric protocols to include anemia screening and potential treatment of infants less than 6-months of age.

Food Consumption, Purchasing and Dietary Pattern of Farm Women in Dharwad District, Karnataka State, India

Present study was undertaken to analyze the socio-economic and nutritional status of women involved in farm activities and to know the impact of nutri-farms on food, nutrition and health security. Using 300 farm women in Chamarajanagar district. Health and nutritional status assessment, food intake, nutritional adequacy and screening for iron deficiency anaemia and KAP study on health and nutrition was conducted. Malnutrition is still one of the crucial problems in developing countries which is relationship between nutrition and health among a majority of the population. The objective of the study was dietary pattern of before and after intervention. This paper tries to analyze the food consumption and dietary pattern of women involved in farm activities and to know the impact of nutri-farms on food and nutrition security by using of 500 farm women in Dharwad district. A well-structured questionnaire was framed to gather the information on dietary pattern of the subjects was assessed by 24– hour diet recall method before and after intervention. The results revealed that, Among cereals, rice was consumed daily (90.4%) by all the families, where as food intake was observed that Pulses (67.67), milk and milk products (167.60), roots and tubers (67.80), GLV’s (47.17), other vegetables (96.47), fruits (37.33), fats and oil (17.70) consumption is very low when compared to RDA whereas consumption of cereal was on par with the recommended dietary allowances. The mean nutrient intake of energy (1794.5 kcal), protein (36.95 g), fat (17.95 g), iron (18.98 mg) and Vitamin C(42.85 mg) were less when compared to the RDA. The results shows that all nutrients and food intake consumption was found inadequate.

A survey on the implementation of Patient Blood Management programs in Italy.

Since 2012, in line with the World Health Organization (WHO) resolution WHA63.12 of 05/21/2010, the Italian National Blood Center has been promoting patient blood management (PBM). In order to verify the level of PBM implementation nationwide, we submitted a survey to all healthcare providers. In line with what was proposed in the international scientific literature in the field, a series of indicators were used derived from the four main blocks related to PBM strategies: the management of patient anemia; the optimization of hemostasis; blood conservation strategies; patient-centred decision-making. We also added two blocks containing important information on general PBM management and other PBM-related aspects. The survey showed good implementation of anemia screening programs in accordance with the timelines established by national and international guidelines, and the single unit policy is used in line with national guideline recommendations. However, the survey also revealed limited auditing of PBM programs and reduced monitoring and reporting of clinical outcomes and indicators. The first national survey on the level of PBM implementation in Italy shows widespread adoption of diagnostic-therapeutic care pathways aimed at the diagnosis and treatment of anemia in the perioperative setting.

Validation of ToucHb, a non-invasive haemoglobin estimation: Effective for normal ranges, needs improvement for anaemia detection.

Non-invasive methods for haemoglobin estimation hold enormous potential for early detection and treatment of anaemia, especially in limited resource settings. We sought to validate the diagnostic accuracy of ToucHb, a non-invasive haemoglobin estimation device available in the Indian market. We prospectively evaluated the diagnostic performance of the ToucHb device using the Automated complete blood count (CBC) method as the gold standard. Persons referred for haemoglobin estimation to the central laboratory of the government medical college hospital in Mysore, southern India were included in the study. Out Of 140 people approached, 127 gave consent; 65% (n = 82) were female with median age of 37 (IQR 28-45). ToucHB reported median haemoglobin value of 14 g/dL compared to 13.3 g/dL for CBC. Within 1 g/dL and 2 g/dL of CBC, 55.2% (70/127) and 74% (94/127) of ToucHb haemoglobin observations fell, respectively. The Bland-Altman plot showed a mean difference of 3 g/dL in haemoglobin between ToucHb and CBC among those with anaemia. The ToucHb device showed 22.2% sensitivity and 94.5% specificity for anaemia detection. In rural resource-limited settings, point of care non-invasive devices such as ToucHb can improve access and acceptance for anaemia screening. However, ToucHb has showed low sensitivity for anaemia detection and low accuracy at lower haemoglobin values. The utility of the instrument is especially limited in detecting anaemia, while it can estimate haemoglobin accurately among those with haemoglobin is in the normal range. Based on these findings, ToucHb and devices that work on the core technology deployed in ToucHb may be better suited to monitor known haemoglobin level rather than in anaemia screening or detection in primary/ secondary care and community settings.

Inpatient management of iron deficiency anemia in pediatric patients with inflammatory bowel disease: A single center experience.

Screening for iron deficiency anemia (IDA) is important in managing pediatric patients with inflammatory bowel disease (IBD). Concerns related to adverse reactions may contribute to a reluctance to prescribe intravenous (IV) iron to treat IDA in this population. To track the efficacy and safety of IV iron therapy in treating IDA in pediatric IBD patients admitted to our center. A longitudinal observational cohort study was performed on 236 consecutive pediatric patients admitted to our tertiary IBD care center between September 2017 and December 2019. 92 patients met study criteria for IDA, of which 57 received IV iron, 17 received oral iron, and 18 were discharged prior to receiving iron therapy. Patients treated with IV iron during their hospitalization experienced a significant increase of 1.9 (± 0.2) g/dL in mean (± SE) hemoglobin (Hb) concentration by the first ambulatory follow-up, compared to patients who received oral iron 0.8 (± 0.3) g/dL or no iron 0.8 (± 0.3) g/dL (P = 0.03). One out of 57 (1.8%) patients that received IV iron therapy experienced an adverse reaction. Our findings demonstrate that treatment with IV iron therapy is safe and efficacious in improving Hb and iron levels in pediatric patients with IDA and active IBD.

Understanding Antenatal Care Service Quality for Malaria in Pregnancy through Supportive Supervision Data in Tanzania.

Malaria in pregnancy (MiP) is associated with maternal anemia, spontaneous abortion, and infant and maternal death. In Tanzania, MiP service data are collected through routine Malaria Services and Data Quality Improvement (MSDQI) supportive supervision rounds at antenatal care (ANC) facilities. Using structured assessment tools, the U.S. President's Malaria Initiative Impact Malaria Project reviewed two annual rounds of MSDQI data (492 facilities in 2021 and 522 facilities in 2022), including ANC records and client satisfaction interviews. We assessed coverage of key MiP care components, used logistic regression to analyze uptake of the recommended three or more doses of intermittent preventive treatment in pregnancy (IPTp3+), and assessed client satisfaction. Coverage of most MiP care components exceeded 80%; however, only 38% of women received all components. Odds of receiving IPTp3+ were much lower among late ANC initiators than among those who initiated ANC during their first trimester (odds ratio [OR], 0.46; 95% CI, 0.38-0.57). Uptake of IPTp3+ increased almost exponentially by number of ANC visits. Women with seven visits were 30 times more likely than those with three visits to receive IPTp3+ (OR, 30.71; 95% CI, 11.33-83.22). Just 54% of clients had anemia screening and only 46% received IPTp3+. Client satisfaction with services and provider communication was high (98% and 97%, respectively); only 8% of client visits exceeded 3 hours. Increased ANC visits could boost IPTp3+ coverage. Routine MSDQI supportive supervision data are useful to assess quality of care, identify service delivery gaps, and guide policies to improve quality of MiP services.

Prevalence of anemia and its social determinants among the male residents of an urban area in Tamil Nadu, India.

India has a high burden of anemia among the South Asian countries. Anemia has been extensively studied in the female and child population, with less attention given to males. The present study aims to assess the prevalence of anemia among males residing in an urban area and associated social determinants. A community-based cross-sectional study was conducted among 300 males (during September and October 2021) in an urban area of Coimbatore, Tamil Nadu. A portable hemoglobin photometer was used to detect the prevalence of anemia. A structured questionnaire was used to collect details on social determinants of anemia such as dietary practice, education, income, and sanitary practices. The mean age of study participants was 34 ± 5.23 years. The prevalence of overall anemia among men was 20.3% (95% confidence interval [CI]: 15.9-25.3%), with moderate and severe anemia being 5.7% (95% CI: 3.3-8.9%) and 1% (95% CI: 0.2-2.9%), respectively. Belonging to a lower socioeconomic class (odds ratio [OR] = 6.50, P < 0.05) and consuming more than two cups of tea (OR = 7.28, P < 0.05) were significantly associated with anemia. Our study depicts a high burden of anemia among males. Health education on the role of dietary factors contributing to anemia needs to be emphasized with special focus on the frequency of tea intake. Primary care physicians can include screening for anemia in their routine practice for men belonging to lower socioeconomic groups. Consideration should be made to include male populations also under the National Anemia Control program.

A Prospective Observational Study of the Prevalence, Risk Factors, Management and Types of Anaemia in Hospitalized Patients in Surat, India

Background: Anaemia is a common condition in hospitalized patients and is associated with adverse clinical outcomes, such as increased morbidity, mortality, and length of hospital stay. However, there is limited research on the prevalence, types, risk factors, and management of anaemia in Surat, India. Methods: We conducted a prospective observational study of 407 hospitalized patients in Surat, India, to investigate the prevalence, types, risk factors, and management of anaemia. Data were collected through case report forms. Hemoglobin levels were used to diagnose anaemia, and the World Health Organization (WHO) criteria were used to classify the severity of anaemia. Results: The results showed that the prevalence of anaemia was highest in the pediatric ward, with microcytic normochromic anaemia being the most common type of anaemia in male and female patients. Moderate anaemia was found to be the most common among the study population. The majority of patients were transfused with RBC for severe anaemia. Conclusion: The findings of this study have implications for the management of anaemia in hospital populations, highlighting the need for targeted interventions for different patient groups and emphasizing the need for improved screening and management of anaemia, particularly in high-risk populations such as pediatric and female patient.

Diagnostic Utility of Reticulocyte Hemoglobin Equivalent Parameter in the Evaluation of Microcytic Hypochromic Anemia – Our Experience from Northeast India

Background: Reticulocytes are red blood cell precursors with an average lifespan of 1–2 days. Reticulocyte hemoglobin equivalent (Ret-He) is an early marker of iron deficiency (ID) erythropoiesis and reflects real-time information regarding the synthesis of young erythrocytes in the bone marrow. The objective of this study is to determine the diagnostic utility of Ret-He in patients having microcytic hypochromic anemia in comparison with serum ferritin and iron studies. Objectives: The objective of this study is to determine the diagnostic utility of the Ret-He parameter in patients having microcytic hypochromic anemia in comparison with the serum ferritin, iron studies and its role in routine hematological screening for nutritional deficiency anemia like ID. Design and Settings: The design involves observational study. Materials and Methods: A hospital-based observational study was carried out in a referral hospital. Hematological parameters were processed using Sysmex XN1000 (Sysmex Corporation, Kobe, Japan) analyzer and were compared with Serum iron studies using biochemistry analyzer (VITROS® 250 Chemistry System) from 201 participants who presented with microcytic hypochromic anemia. Main Outcome and Measures: Relationship of Ret-He parameter and its diagnostic utility for screening of iron-deficient states. Sample Size: The sample size was 201. Results: When serum ferritin is taken as “the gold standard” to detect ID, with Ret-He cutoff of 27.15 pg/cell, we found a statistically significant positive correlation between Ret-He and serum ferritin (P &lt; 0.001). We found a sensitivity of 57.37% and specificity of 75.95% with area under the curve of 0.681, positive predictive value of 100%, negative predictive value of 3.8%, and accuracy of 62.19% for Ret-He in detecting ID anemia (IDA). Also found a statistically significant negative correlation between Ret-He and total iron binding capacity (P &lt; 0.001). There was no statistical correlation between Ret-He and serum iron levels in our study. Conclusions: The present study suggests Ret-He is one of the better and more reliable hematological parameters indicating ID and, when used along with biochemical parameters like serum ferritin, can give valuable inputs in a better screening and diagnosis of IDA; hence proper treatment is possible. Limitations: The multicentric study is required to standardize Ret-He reference values, and follow-up to therapy of the subjects was not done. Additional hemoglobin variant analysis data would have been favorable to the study.

Penyuluhan Skrining Anemia dan Pemberian Tablet Fe pada Remaja di SMP 4 Menggala

Anemia is a condition where the hemoglobin level in the blood is less than the normal level. Adolescent girls are at high risk of anemia, because during this period there is an increased need for iron due to growth and mensturation. School activities and high extracurricular activities will have an impact on irregular eating patterns, besides the habit of consuming drinks that inhibit iron absorption will affect one's hemoglobin levels. Adolescent girls are required to take Blood Addition Tablets because they experience menstruation every month. Blood Add Tablet is useful to replace iron lost due to menstruation and to fulfill iron needs that have not been fulfilled from food. Iron in adolescent girls is also useful for improving learning concentration, maintaining fitness and preventing anemia in future mothers. The implementation of this community service activity was held at SMP 4 Tulang Bawang Regency on January 14, 2024. Participants who took part in the education "Counseling on Anemia Screening and Providing Fe Tablets to Adolescents" were 20 junior high school students from SMP 4 menggala. Based on the counseling care carried out, it is known that knowledge about anemia in adolescents, the average knowledge before is 50.5 and after is 87.5, it can be seen that there is an effect of the counseling provided, from counseling it is also seen that the mean difference is 37%. The p-value = 0.000 (p-value &lt; α = 0.05) means that there is an effect of counseling on knowledge about anemia in adolescents.

Prevalence of Anemia in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis

ObjectiveAnemia is a common public health concern in patients with type 2 diabetes worldwide. This study aimed to identify the prevalence of anemia among patients with diabetes. MethodsElectronic databases, including PubMed, Scopus, Web of Sciences, and Google Scholar, were searched systematically for studies published between 2010 and 2021. After removing duplicates and inappropriate reports, the remaining manuscripts were reviewed and appraised using theNewcastle-Ottawa Scale (NOS) tool. A random-effects model was used to calculate the pooled estimates of the extracted data using Stata version 17. Heterogeneity of the studies was assessed using the Q statistic. ResultsA total of 51 articles containing information on 26,485 patients with diabetes were included in this study. The articles were mainly from Asia (58.82%) and Africa (35.29%). The overall prevalence of anemia was 35.45% (95% CI: 30.30–40.76), with no evidence of heterogeneity by sex. Among the two continents with the highest number of studies, the prevalence of anemia in patients with diabetes was significantly higher in Asia [40.02; 95% CI: 32.72–47.54] compared to Africa [28.46; 95% CI: 21.90–35.50] (P for heterogeneity = 0.029). Moreover, there has been an increasing trend in the prevalence of anemia in patients with diabetes over time, from [15.28; 95% CI: 9.83–22.21] in 2012 to [40.70; 95% CI: 10.21–75.93] in 2022. ConclusionGlobally, approximately 4 in 10 patients with diabetes suffer from anemia. Therefore, routine anemia screening and control programs every 3 months might be useful in improving the quality of life of these patients.

Prevalence and associated factors of anemia among elderly patients at a tertiary hospital in Estern Ethiopia: a cross-sectional study

Background: As anemia is a prevalent condition in geriatrics and old age and its frequency proportionately increases with age, leading to severe consequences; any magnitude of it is now recognized as a risk factor for any adverse outcomes: decreased quality-of-life, hospitalization, morbidity, and mortality. Despite its clinical importance, the problem is not widely recognized. Therefore, regular surveillance could provide evidence-based local data required for interventions. This study is aimed to assess the prevalence and associated factors of anemia among elderly patients in eastern Ethiopia. Methods: From June 20 to July 30, 2022, a cross-sectional study centered in an institution was carried out, enrolling 381 elderly patients. Direct interviewing and review of medical records were used to gather socio-demographic and clinical data. Each participant provided a venous blood sample to determine total blood cell count and blood peripheral film examination; to identify hemoparasites and the morphological type of anemia. Using SPSS version 25, descriptive statistical analysis and bivariate and multivariate logistic regressions were used, and statistical significance was set at p&lt;0.05. Result: Anemia was seen in 40.4% of participants, mild, moderate, and severe anemia accounts for 71.1%, 23.1%, and 5.8%, respectively. Normocytic normochromic anemia was seen in 55.13% of cases, and microcytic hypochromic in 37.18%. The anemia was substantially correlated with being male [AOR=0.352 95% CI: 0.174, 0.708], having a lower socioeconomic status [AOR=0.041 95% CI: 0.011, 0.156], and eating meat less than once per week [AOR=0.301 95% CI: 0.114, 0.793]. Conclusion and recommendation: The prevalence of anemia among elderly patients in this area was found to be a severe public health problem. Mild anemia was the predominant type. Identified risk factors should be considered to prevent and control anemia, and screening for anemia among the elderly should be a part of their routine management.

Unveiling the Link: Anemia as a Risk Factor for Cerebrovascular Accidents

Anemia, a prevalent hematological condition characterized by decreased red blood cell count or hemoglobin levels, has emerged as a significant risk factor for cerebrovascular accidents (CVAs) and commonly known as strokes. This review explores the intricate connection between anemia and the occurrence of CVAs, elucidating the underlying mechanisms and clinical implications. Anemia contributes to stroke risk through multiple pathways, including impaired oxygen delivery to the brain, alterations in cerebral hemodynamics, and disruption of neurovascular homeostasis. Furthermore, iron deficiency anemia’s predominant etiology-not only exacerbates hypoxia but also compromises neuronal integrity, predisposing individuals to ischemic and hemorrhagic stroke events. The hemodynamic consequences of anemia, including cerebral hypo-perfusion and increased thromboembolic risk, underscore its role as a silent culprit in stroke pathogenesis. Anemia-induced alterations in blood viscosity, endothelial dysfunction, and compensatory vasodilation contribute to the vulnerability of cerebral vasculature to ischemic insults. Moreover, iron deficiency exacerbates neurocognitive impairment and promotes neuro degeneration, exacerbating the risk of vascular cognitive decline and hemorrhagic stroke. Routine screening for anemia, particularly in highrisk populations, coupled with targeted interventions aimed at correcting underlying etiologies and optimizing hemoglobin levels, is essential for mitigating stroke risk and improving clinical outcomes.

Prevalence of Anemia and Hemoglobin Distribution Based on Large-scale Occupational Health Examination Data.

Objective To calculate the prevalence of anemia based on sex and age using large-scale occupational health examination data, confirm the Hb) distribution in the elderly, and examine the standard for screening for anemia in Japan. Methods Using existing large-scale occupational health examination data of patients who underwent health examinations between April 2015 and March 2022, we calculated the prevalence of anemia based on sex and age. Patients We included 416,366 patients aged 20-89 years who underwent health checkups at health checkup facilities in Japan. Results Of the patients, 53.5% were men. The proportion of previously anemic individuals was 3.2% in men and 19.7% in women, with Hb levels (mean ± SD) of 15.1±1.1 g/dL in men and 13.1±1.2 g/dL in women. The prevalence of anemia showed a monotonic increase with age in men and a bimodal distribution, peaking in women in their 40s and 70s. Among women in their 20s-40s, 17.9% had anemia, and 60% were newly diagnosed. Furthermore, the mean -2SD of Hb in the elderly men (>65 years) was 12.0 g/dL, larger than the current standard (11.0 g/dL). Conclusion It is imperative to consider the possibility of anemia in young women during health examinations and other screening opportunities, regardless of their history of anemia. In addition, elderly men with Hb levels <12 g/dL should be cautioned about the development of anemic symptoms and the progression of Hb decline.

Sickle Cell Anemia Screening in Newborns and Analysis of Haplotypes in Patients from Santiago Island, Cape Verde.

Sickle cell anemia (SCA) results from a mutation in the β-globin gene, leading to the production of mutant hemoglobin, known as hemoglobin S (HbS). Despite being a genetic disorder, the phenotype of SCA can be influenced by the level of fetal hemoglobin (HbF), which is associated with beta S-globin haplotypes. In this study, we conducted newborn screening (NBS) using samples collected from umbilical cord blood in two hospitals on Santiago Island, Cape Verde. In newborns, HbS was detected using high-performance liquid chromatography (HPLC) on dried blood spot, with confirmation through polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). In addition, we assessed the hematological and clinical characteristics of a second population group consisting of patients diagnosed with SCA. Haplotype determination was performed on both newborns with HbS and patients with SCA. Beta S-globin haplotypes were determined using PCR-RFLP. Hematological values were analyzed using standard methods. Out of 346 newborns, 21 (6%) were carriers of the sickle cell trait (HbAS) while none were identified as homozygous for sickle cell disease (HbSS). Among both groups of individuals, four haplotypes were identified: Senegal, Arabi-Indian, Bantu, and Benin. The Senegal haplotype was the most prevalent, possibly reflecting the ethnic origin of the mutations observed. Hematological values did not differ significantly among haplotypes. However, higher levels of HbF were associated with better hematological values. These findings suggest a positive impact of elevated HbF levels on reducing the severity of SCA. Finally, we demonstrated how the combination of technics, HPLC and molecular analysis, provided a consistent and reproducible results that can be used for NBS for SCA.

Diagnosis of anemia using non-invasive anemia detector through parametrical analysis

Anemia, characterized by low hemoglobin levels, affects a significant portion of the global population, particularly children and women in low- and lower-middle-income countries. Traditional hematological tests for diagnosing anemia can be invasive, costly, and resource-intensive. This study presents the development of a wearable, non-invasive anemia detector utilizing infrared (IR) technology. The device integrates a NodeMCU microcontroller, an OLED display, a buck converter, an IR transmitter, and a receiver in a compact, wearable package. The IR system measures hemoglobin levels by analyzing the absorption of infrared light emitted through the skin, typically on a fingertip or earlobe. The NodeMCU processes the light absorption data using sophisticated algorithms to determine hemoglobin concentration and facilitates wireless data transfer to smartphones or cloud servers for further analysis. The device is designed with energy efficiency in mind, utilizing a buck converter to ensure optimal power distribution to sensitive components. The OLED display provides users with clear, real-time feedback on their hemoglobin levels, offering a user-friendly interface. Initial testing and calibration with known hemoglobin concentrations demonstrated strong correlations between device readings and traditional lab tests. The device employs a hierarchical ensemble classifier to categorize individuals as healthy, mildly anemic, or severely anemic, aligning with clinical standards. The non-invasive nature of this device, combined with its portability and cost-effectiveness, makes it an ideal solution for point-of-care anemia detection, particularly in resource-limited settings. The integration of IR technology, microcontroller processing, and wireless communication presents a practical tool for healthcare providers, facilitating rapid anemia screening and ongoing monitoring. This innovation holds the potential to improve patient outcomes by enabling early detection and intervention in anemia management.

Effect of poor glycemic control on the prevalence and determinants of anemia and chronic kidney disease among type 2 diabetes mellitus patients in Jordan: An observational cross-sectional study.

Anemia and chronic kidney disease (CKD) are common findings in diabetic patients. Lack of glycemic control is associated with increased risk of diabetic complications. This study aimed to determine the effect of poor glycemic control on the prevalence and determinants of anemia and CKD among type 2 diabetes mellitus (T2DM) patients in Jordan. A cross-sectional study design was used in this research. T2DM patients with controlled diabetes (HbA1c ≤7.0%, n = 120) and age-, gender- and body mass index-matched uncontrolled diabetic patients (HbA1c >7.0%, n = 120) were recruited. Blood sample for HbA1c and serum insulin measurement were obtained. Complete blood count and kidney function test results were obtained from the patient's medical records. Anemia was determined according to World Health Organization criteria. A binomial logistic regression was performed to ascertain the effects of age, gender, CKD and glycemic control on the likelihood that participants have anemia. The prevalence of anemia was significantly higher in the uncontrolled T2DM compared to controlled T2DM patients (40% vs 27.5%, OR: 2.14, 95% CI: 1.23, 3.71, P = 0.006). Female patients with uncontrolled T2DM had significantly greater prevalence of anemia compared to male patients with uncontrolled T2DM. The binomial logistic regression analysis showed that age, female gender, and CKD were positively associated with anemia in the multivariate model, while in the univariate model, lack of glycemic control increases the odds of anemia by 1.74 (95% CI: 1.01, 2.99, P = 0.046). Anemia is commonly present among T2DM patients in Jordan and is associated with poor glycemic control especially in females. These results emphasize the necessity of including anemia screening in standard diabetes care to enable early detection and treatment of anemia and to enhance the overall care of diabetic patients.

Skrining Anemia Melalui Pemeriksaan HB, TIBC dan Serum Iron Pada Remaja Putri di SMK Baitul Hikmah Tempurejo

&lt;p&gt;&lt;em&gt;Anemia is a public health problem in Indonesia that can be experienced by all age groups, from toddlers to the elderly. One of them is young women, where these young women are prone to anemia due to a lot of blood loss during menstruation, young women who are entering puberty experience rapid growth so that the need for iron also increases and there is an incorrect diet pattern in rhymes. Adolescent girls who suffer from anemia are also at risk of developing anemia during pregnancy. This will have a negative impact on the growth and development of the fetus in the womb and has the potential to cause complications during pregnancy and childbirth. The purpose of this activity is to screen for iron deficiency anemia in young women as a preventive measure for anemia in adolescents which can cause long-term adverse effects on adolescents.&lt;/em&gt;&lt;/p&gt;&lt;em&gt;Screening for iron deficiency anemia in this activity was carried out through laboratory examination of panel iron levels, especially TIBC and Serum Iron examinations in young girls. The target for this activity is young women at Baitul Hikmah Tempurejo Vocational School. Screening begins with anamnesis and physical examination. If there are indications that lead to anemia, an iron panel examination (TIBC and serum iron) will be performed. The results obtained will be analyzed and consulted with the local regional health officer to get the right treatment&lt;/em&gt;

Screening and treatment of iron deficiency anemia in pregnancy: A review and appraisal of current international guidelines.

Iron deficiency anemia (IDA) in pregnancy is a common diagnosis that is associated with adverse obstetric and neonatal outcomes. There remains uncertainty regarding how best to screen for, prevent, and treat established IDA in pregnancy. There is no consensus on the benefits of routine iron supplementation in pregnancy, with concerns regarding potential harmful effects of routine iron supplementation in women who are iron replete. Fourteen international guidelines were selected and appraised and compared by a multidisciplinary team. The AGREE II GRS tool was used. Each reviewer independently made their own assessment, and the scores from 1 to 7 were also collated and averaged for an overall score incorporating seven domains: process of development, clarity of presentation, completeness of reporting, clinical validity, and overall quality. The reviewers' scores were also individually compared according to discipline. The mean score across all the guidelines was 4.4 (range 3.5-6.5). Only half of the guidelines recommend routine iron in pregnancy. In terms of screening recommendations, five guidelines recommend screening with ferritin in addition to a full blood count in pregnancy, two recommend selective screening with ferritin for at risk groups only, and one guideline suggests using ferritin where feasible. Although many of the guidelines recommend similar doses of oral elemental iron of 100-200 mg daily for the treatment of established IDA in pregnancy, two recommend twice or three times daily dosing. Only five guidelines give hemoglobin rises to expect within specific timeframes. There remains a need to clarify the optimal screening method, dosing regimen, timing, and route of iron supplementation in pregnancy. Robust randomized controlled data are needed to guide appropriate prevention and management.

Accuracy of HemoCue301 portable hemoglobin analyzer for anemia screening in capillary blood from women of reproductive age in a deprived region of Northern Peru: An on-field study.

We aim to assess the accuracy and effectiveness of the HemoCue 301, a point-of-care (POC) device for measuring hemoglobin levels, and detecting anemia among individuals living in Tumbes, a rural, underserved area in Northern Peru. Baseline analysis of a clinical trial aimed at assessing the effect of multi-fortified bread (NCT05103709). Adult women with capillary blood HemoCue 301 readings below 12 g/dL were recruited in coastal city of Tumbes, Peru. A total of 306 women took part of the study, venous blood samples were taken and analyzed with an automated hematology analyzer. Serum samples were used to measure ferritin, serum iron and C reactive protein. Capillary blood measured by the Hemocue 301 has a bias of 0.36 ± 0.93 g/dL respect to the automated Hb. More than 50% of women with normal ferritin values were classified as anemics according to the HemoCue 301. Automated Hb cut-off of 10.8 g/dL [AUC 0.82 (0.77-0.88)] had a specificity of 0.817 and a sensitivity 0.711 while with the HemoCue 301 cut-off of 11.1 g/dL [AUC 0.71 (0.62-0.79)] had a specificity of 0.697 and a sensitivity 0.688. The performance of the automated Hb cut-off was significantly better than the HemoCue (p<0.001). Caution must be taken when using POC devices, especially with values around the threshold. Cut-off values found in our study could be used as surrogate means when no confirmatory tests are available. Clinical outcomes should be prioritized when diagnosing iron deficiency anemia in women of reproductive age to ensure proper diagnosis.