Scientific Research Research Articles

Potansiyel bisphenol-A ikameleri sucul yaşam için gerçekten güvenli mi? Birincil üreticiler üzerindeki etkisi

Bisphenol A threat to environmental health and human health and has been added to the Candidate List as Very High Concern Substances by the European Chemicals Agency. This led to the replacement of bisphenol A (BPA) with bisphenol analogues, which were considered "safer". However, there are very few scientific studies on the impact of BPA analogues on the environment. In this study, three analogues bisphenol B (BPB), bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) were selected to investigate their ecotoxicological effects on the marine phytoplankton species Phaeodactylum tricornutum, which is representative of primary producers. Phaeodactylum tricornutum was exposed to different concentrations (0.5, 0.8, 1.0, 1.5, 2.0 mg/L) of BPB, BADGE and BFDGE analogues for 72 hours and the toxicity values of three BPA analogues were calculated by OECD 201 algal growth inhibition assay (IC50/EC50). In the light of the data obtained, algal growth inhibition (IC50/EC50) values for marine phytoplankton Phaeodactylum tricornutum were determined as 3.91 mg-BPA/L, 7.83 mg-BPB/L, 5.69 mg-BFDGE/L, 11.71 mg-BADGE/L. The results revealed that BPB, BFDGE and BADGE showed lower toxicity to Phaeodactylum tricornutum compared to BPA algal growth inhibition (3.91 mg-BPA/L). Therefore, it is necessary to share the results of the adverse effects of BPA analogues on aquatic organisms and to conduct ecotoxicological risk assessments.

The concept that went viral: Using machine learning to discover charisma in the wild.

The term "charisma" is recognized as sociology's most successful export to common speech. While sociologists habitually dismiss popular uses of the word, we address its vernacularity head on as a worthy object of study and as a potential resource for conceptual development. Using machine learning, we locate "charisma" within the wider discursive field out of which it arises (and continues to arise) across four corpora; namely: Weber's major writings; social scientific research (123,531 JSTOR articles); and social media ("X") posts containing of "charisma" (n=77,161) and its 2023 variant, "rizz" (n=85,869). By capturing meaning structures that discursively suspend "charisma" across multiple dimensions, we discern three spectrathat help todistinguish charisma's sociological and non-sociological uses. Spectrumone differentiates perspectives which see charisma as having either a structural or individual-level range of efficacy. Spectrumtwo differentiates indifferent/analytical perspectives on charisma from perspectives which see it as desirable but also morally conservative. Spectrumthree differentiates between relational and individualized ontologies for charisma. We find that, rather than hewing closely to the Weberian formulation, social scientific uses exist in an intermediate position vis-à-vis these three spectra. Thus, scholars participate in what they otherwise criticize as charisma's vulgarization. The article concludes with recommendations for how to constructively interact with 'popular charisma.'

Spreading the “scientific approach”: the chemical turn in conservation from the Musée d’ethnographie du Trocadéro to colonial museums in the French empire

ABSTRACT This text retraces the installation of the laboratory in the Musée d’ethnographie du Trocadéro in the 1930s. It questions the ambitions that lay behind the “scientific” conception of museum conservation as promoted by the museum’s technical assistant, Adrien Fédorovsky, in parallel with many other European museums. Particular attention is paid to chemical methods of conservation and the setting up of toxic chambers. The products used and their suppliers are documented, and overlaps with other social fields sketched out. Finally, the text traces the spread of chemical conservation methods to planned and completed museums in the French empire.

Judges and lawyers’ beliefs in repression and dissociative amnesia may imperil justice: further guidance required

ABSTRACT This article examines continuing misunderstanding about memory function especially for trauma, across three UK samples (N = 717). Delayed allegations of child sexual and physical abuse are prevalent in Western legal systems and often rely upon uncorroborated memory testimony to prove guilt. U.K. legal professionals and jurors typically assess the reliability of such memory recall via common sense, yet decades of scientific research show common sense beliefs often conflict with science. Recent international surveys show controversial notions of repression and accurate memory recovery remain strongly endorsed. In historical cases, these notions may lead to wrongful convictions. The current study surveyed the U.K. public, lawyers, and mental health professionals’ beliefs about repression, dissociative amnesia and false memories. Study findings give unique data on judges’ and barristers’ beliefs. Overall, the study findings reinforce international scientists’ concerns of a science – knowledge-gap. Repression was strongly endorsed by lay, legal and clinical participants (> 78%) as was dissociative amnesia (> 87%). Moreover, suboptimal professional legal education and juror guidance may increase misunderstanding. Correcting beliefs about memory function, and extending the contribution of memory science in the courtroom remains an important quest for cognitive scientists.

Power dependent tunable optical nonlinearity in Iron oxide/Borophene core-shell nanoparticles under ultrashort laser excitation

Two-dimensional (2D) nanomaterials find immense applications in ultrafast photonics and optical switching systems due to their fascinating nonlinear optical (NLO) characteristics. This work presents a systematic investigation of laser power-dependent nonlinear optical characteristics of borophene nanosheets in a core-shell nanostructure. For this purpose, we have synthesized Borophene encapsulated Iron oxide (Fe3O4) core-shell nanoparticles (Fe3O4/Borophene CSNPs). The CSNPs were synthesized by mixing and annealing sodium borohydride (NaBH4) as a boron precursor with iron oxide nanoparticles (Fe3O4 NPs) in a controlled environment using chemical vapor deposition technique (CVD) followed by characterization using XRD, FTIR Spectroscopy, UV–vis absorption spectroscopy, TEM, SEM, and EDX techniques. Magnetic properties were analyzed by a vibrating sample magnetometer (VSM) which shows that the saturation magnetization of Fe3O4 NPs increases after being encapsulated in borophene nanosheets. The role of borophene in modifying the NLO characteristics of Fe3O4/Borophene CSNPs was studied using a power-dependent Z-scan technique utilizing ultrashort (femtosecond) laser pulses at a wavelength of 800 nm in both open and close aperture configuration. It was found that borophene-coated Fe3O4 NPs reveal tunable NLO properties that resemble the NLO characteristics of borophene nanosheets with enhanced features. This provides insights into an interaction between materials in NLO phenomena and illustrates the distinctive performance of the core-shell nanostructure. The tunable NLO properties of Fe3O4/Borophene CSNPs offer an innovative approach for developing optoelectronics and ultrafast nonlinear photonic devices.

Unpuzzling spatio-vertical and multi-media patterns of aniline accelerators/antioxidants in an urban estuary

Aniline accelerators and antioxidants (AAs) are high-production-volume industrial additives that have recently attracted emerging concern given their ubiquity in environmental compartments and the associated (eco)toxic effects. Nonetheless, available information on the multi-media behavior of AAs and their transformation products (TPs) remains scarce. Therefore, we determined the residues of twenty-four AA(TP)s in paired dissolved phases (i.e., filtered water), suspended particulate matter (SPM), and sediment samples collected from the Yangtze River Estuary (YRE), a highly urbanized estuary in the East China. The median total concentrations of targeted compounds were 0.73 ng/g dw, 34.4 ng/L, and 39.6 ng/L in sediments, surface and bottom water, respectively. Diphenylamine (DPA) was the most abundant congener in SPM, while 1,3-diphenylguanidine (DPG) and dicyclohexylamine (DChA) dominated in the dissolved phases and sediments. Various anthropogenic emissions and (a)biotic degradation may collectively shape the matrix-specific accumulation patterns and spatial trends of these compounds across the YRE. However, the vertical patterns of AA(TP)s were obscure, probably due to the estuarine hydrodynamics and/or the modest sample size. The SPM fractions of AA(TP)s in water (Ф: 7.9–100%) and the sediment sorption coefficients (KOC: 0.01–6.56) both positively correlated with their hydrophobicity as indicated by the octanol-water partition coefficient (KOW). Moreover, risk quotients implied moderate to high aquatic toxicity posed by several AA(TP)s at certain YRE sites. The estimated total annual fluxes of our analytes transported via water and sediments towards the East China Sea were 5.90–365.5 tons and 4.23–1,100 kg, respectively. This work provides a systematic investigation of multi-media processes and ecological risks of AA(TP)s in a highly-urbanized estuary, contributing to holistic comprehension of these emerging contaminants in estuarine environments.

MAIN PROBLEMS OF ENSURING SUSTAINABLE DEVELOPMENT OF THE STATE IN DIGITAL SPACE

The authors characterise the concept of ‟digital space”, describe its meaning and distribution parameters. The periods of the history of the origin and formation of the digital space during the information technology revolution are considered. The main groups of processes taking place in the digital space and having the strongest impact on the sustainable development of the state are highlighted. The risks for the sustainable development of the state in the context of the use of highly efficient means of processing and transmitting information, the formation of a ‟digital society”, as well as the use of artificial intelligence in public administration are described. The methodological basis of the work is the general scientific methods of logical, comparative legal, normative legal analysis. The possibilities of an interdisciplinary approach to research are used. The author’s definition of the concept of ‟digital space” is formulated and the main conceptual provisions for the draft law of the Federal Law proposed by the authors are formulated.

Development and characterization of atmospheric pressure gliding Arc plasma jet

In this work, we present the development and comprehensive characterization of an atmospheric pressure gliding arc plasma jet (GAPJ) operating in ambient air to generate non-thermal plasma. Through systematic investigation, the relationship between jet length and airflow rate indicates a positive correlation. Electrical and optical techniques are utilized to characterize the discharge, revealing an impact of applied voltage and gas flow rate on discharge parameters. Calculations are made for parameters such as electron density ((0.62−3.44)×1019) m −3, average power dissipation (9.85−40.50) W, and root mean square values of current and voltage. The impacts of applied voltages and gas flow rate on these parameters are also examined. Electron excitation temperature is determined using the Boltzmann plot method, yielding values within the range of (1.36−1.44) eV. Rotational and vibrational temperatures of discharge are analyzed, revealing values of (1373−2065) K and (2700−2405) K, respectively, under different operational conditions. The generated non-thermal plasma is confined to form a plasma plume although it consists of two diverging electrodes and offers promising applications for specified areas of sterilization and decontamination in the medical, pharmaceutical, and food processing industries.

Self-grown carbon nanotubes supported fluorine-free Mo2CTx conductive layers for efficient potassium storage

Mo2CTx is relatively less studied among MXenes family, especially for rechargeable alkali metal ion batteries. Herein, a systematic investigation has been conducted to unlock its potential as electrode materials in potassium-ion battery (PIBs), including innovative fluorine-free synthesis strategy, construction of heterostructure, and exploration of suitable electrolyte systems. Firstly, Cetyltriethylammnonium bromide (CTAB)-assisted etching route was provided to fabricate high-quality multilayer Mo2CTx with expanded interlayer space (C-Mo2CTx). The as-obtained C-Mo2CTx demonstrates a large specific capacity of 200 mAh g−1over 300 cycles in potassium-ion battery, surpassing the HF etched counterparts (F-Mo2CTx) by about 300 %. Afterwards, Zeolitic Imidazolate Frameworks (ZIF-67) derived Co, N-codoped carbon nanotubes (Co@NCNTs) were homogenously grown on the surface of Mo2CTx, working as embedding spacer to open the stacked Mo2CTx conductive layers (Mo2CTx-Co@NCNTs). Mo2CTx-Co@NCNTs electrode represents stable reversible capacity of 280 mA h g−1 over 300 cycles. The highly conductive matrix constructed by the strong bond between CNTs arrays and Mo2CTx conductive layer could provide numerous K-ion-diffusion pathways, and buffer volume strain and facilitate electron transfer. The present work proves the potential of Mo2CTx in PIBs and gives the systematic research methodologies on Mo2CTx-based materials in alkali metal ion storage.

Leaf-like MSX/TiN heterojunction photocathodes mimicking plant cell – An effective strategy to enhance photoelectrocatalytic carbon dioxide reduction and systematic mechanism investigation

Semiconductors, such as metal oxides and metal sulfides (MSX), are widely investigated as effectively catalytic materials to convert carbon dioxide (CO2) and water into chemicals under simulated solar light. These valuable investigations might address both the energy crisis and climate change in our modern society. Herein, a novel strategy to construct leaf-like heterojunctions of VS-ZnIn2S4/TiN-x is reported. The new semiconductor heterojunctions were then applied to photoelectrocatalytic CO2 reduction, achieving excellent performance (formate formation rate of 1173.2 μM h−1 cm−2) attributed to the plant cell-like morphology and enhanced electron mobility from the heterojunction interfaces to the active sites on the surface. Our findings suggest that titanium nitride (TiN) with good conductivity can improve the photoelectrocatalytic ability of MSX through heterojunction construction. The photocathode VS-ZnIn2S4/TiN-3 exhibits 81.0 % selectivity toward C2 products by optimizing the material structure and reaction conditions. According to the systematic investigation of operando Fourier transform infrared (FTIR) spectra, common intermediates such as *COO−, *COOH, *CO, *CHO, *COCHO, and *COCH3 reported in the literature were carefully verified. Among these, the carbene specie serve as the key intermediate responsible for generating other intermediates and resulting in all products.

Advertisements for prescription-free drugs and dietary supplements in the Deutsche Apotheker Zeitung (German Pharmacist Journal).

The Deutsche Apotheker Zeitung (DAZ, German Pharmacist Journal) is an independent pharmaceutical newspaper focusing on science and practice, mainly for the profession of pharmacist. In this study, drug advertising in the DAZ was analysed. To our knowledge, there is little scientific data available on drug advertising in professional journals. We assumed that professional journals provide particularly good background information on the advertised drugs because they are targeted to specialists. All non-prescription medicines and preparations that fall under the Medicines Advertising Law (Heilmittelwerbegesetz, HWG) were studied. The Medicines Advertising Law regulates the legal procedure for advertising medicinal products in Germany. The 167 product advertisements from the 52 issues of 2021 were analysed and checked for compliance with the Medicines Advertising Law. We identified significant deficiencies in compliance with the legislation. These included the lack of mandatory information required by the Medicines Advertising Law, for example the indication of adverse drug reactions and the listing of contraindications. There are very few peer-reviewed references on the efficacy of the advertised preparations. A scientific validation was carried out using the PubMed database, with the result that scientific information was available only for 1/3 of the advertisements. In addition, the appearance and target groups as well as social structures, images and feelings conveyed by the advertising were analysed. This study provides insights into the mechanisms of drug advertising in professional journals, which have not yet been researched to any great extent. Even in professional journals, pharmacological evidence plays a much smaller role than marketing, psychology and traditional social values. It seems that drug manufacturers deliberately ignore the German Medicines Advertising Law to advertise their products in the best possible way. Stricter legal controls should be put in place to prevent this practice and protect consumers from misinformation. This will increase drug safety.

Local buckling behaviour of web perforated cold-formed steel lipped channel columns

To connect beams and bracings with storage rack uprights, closely spaced perforations are provided along the web, flanges, and rear flanges of uprights. These perforations can significantly lower the ultimate capacity of such compression members with the possible influence of its natural buckling modes. This capacity reduction can depend on various parameters such as (a) geometrical shape, proportioning of cross-section, and stiffeners; (b) perforation shape, size, spacing, and location; (b) slenderness of member, cross-section, and elements of cross-section; and (d) material properties. A thorough understanding of the influence of the above-mentioned factors is necessary for the accurate strength prediction of perforated Cold-formed steel (CFS) compression members. Even though the current design standards are updated for the accurate strength prediction of unperforated CFS compression members, they do not collectively account for the influence of all the aforementioned factors on the load-carrying capacity of the perforated CFS members, particularly for the local buckling capacity. Though the Direct Strength Method (DSM) of design is the most accepted method for accurate strength prediction of CFS members even for complex cross-sectional shapes, recent research on the strength evaluation of perforated CFS members using DSM has emphasized the need for refinement in DSM. The Modified Direct Strength Method (MDSM), which accounts for the simultaneous buckling of flanges and web, includes the cross-section aspect ratio and cross-section slenderness to predict more accurately the local buckling design strength. However, it was developed only for unperforated specimens. Hence, a systematic experimental and numerical investigation was done to understand the influence of the perforation in the local buckling behavior of the lipped channel section. In total, 14 specimens, including 2 unperforated and 12 web perforated CFS lipped channel stub columns were physically tested with fixed support conditions. The Finite Element Analysis using ABAQUS software was used to conduct an extensive parametric numerical study. The results were used to compare the strength curves of DSM and MDSM and the modification in the design curves has been proposed by considering the erosion in strength due to the presence of perforation.

Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context

Although emerging evidence on the association between per- and polyfluoroalkyl substances (PFASs) and neurodevelopment have been investigated, there is no consensus on the effect of maternal PFASs on neurodevelopment in offspring. Here, we assessed the risk of maternal PFASs exposure on the neurodevelopment of offspring using a novel Targeted Risk Assessment of Environmental Chemicals (TRAEC) strategy based on multiple evidence. The evidence from five online databases were analyzed the effect of PFASs on neurodevelopment. The potential neurodevelopment risk of PFASs was evaluated by the TRAEC strategy, which was conducted on a comprehensive scoring system with reliability, correlation, outcome fitness and integrity. The studies from five databases and additional researchers’ experiments were included the present study to proceed following risk assessment. Based on the framework with TRAEC strategy, the comprehensive evaluation of health risks was classified as low (absolute value 0–4), medium (absolute value 4–8), high (absolute value 8–10). In the present study, the effect of PFASs exposure on neurodevelopment was a medium-risk level with 5.61 overall risk-score. The population-attributable risk (PAR) was 8.26 % for maternal PFASs exposure. The study identified a low-risk effect of prenatal PFASs exposure on ASD and behavioral disabilities. The chain length, type of PFASs and neurodevelopmental trajectories contributed to the risk of maternal PFASs on the neurodevelopment of offspring. Consistent with results of four criteria-based tools (ToxRTool, SciRAP, OHAT and IRIS), health risk assessment based on the TRAEC strategy demonstrated robustness and reliability in the present study. These results illustrated a medium-risk effect of maternal PFASs exposure on neurodevelopmental disorders of offspring. In addition, the TRAEC strategy provided a scientific and structured method for effect evaluation between prenatal PFASs and neurodevelopmental disorders, promoting the consistency and validation in risk assessment.

Cnicus benedictus: Folk Medicinal Uses, Biological Activities, and In Silico Screening of Main Phytochemical Constituents.

Traditional medicine has long recognized the therapeutic potential of Cnicus benedictus, and recent scientific research has shed light on the pharmacological properties of this plant. The bioactive compounds that can be extracted from it, such as the sesquiterpene lactones arctigenin, arctiin, and cnicin, are very interesting to researchers.In this article, based on available data from pre-clinical in vitro and in vivo studies, we delve into the pharmacology of the active constituents of this plant to explore its potential therapeutic applications and underlying mechanisms of action. In addition, we present a computer analysis designed to reveal the pharmacokinetic and toxicological properties of the main phytochemicals that are active in C. benedictus through new in silico techniques and predictive tools such as SwissADME and PubChem.The data from the in silico study presented here support the traditional use of C. benedictus, as well as its promise as a source of new therapeutic chemical compounds.

Establishment of Nano-ITO induced rat model of indium lung disease and exploration of its pathological characteristics

Objective: To study the dynamic pathological characteristics of lung tissue in a Nano-ITO induced rat model of indium lung disease and to guide clinical and basic scientific research to further explore the mechanisms of pulmonary interstitial injury and pulmonary alveolar proteinosis (PAP). Methods: Dose-response (three divided doses) and time-course studies (six exposure periods) were performed to investigate the pulmonary toxicity induced by Nano-ITO. At the end of the experiment, cytokine levels and oxidative stress were analyzed in the bronchoalveolar lavage fluid. Rat lung tissues were also collected for staining with H&E, PAS, Masson's, Oil Red O, and Sirius Red. Ultrastructure of lung tissue cells was observed by transmission electron microscopy. Expression of IL-1β, HO-1, SP-A was observed by immunohistochemistry, and the expression of α-SMA was observed by immunofluorescence. Results: Nano-ITO intratracheal instillation caused pulmonary toxicity by inducing acute inflammation at 3 days, granuloma (nodule) formation and collagen hyperplasia at 14 days, and alveolar proteinosis at 56 days post-exposure. Pathological features of lung tissue included typical alveolar exudates, cellular fibrous nodules, enlarged alveolar fat droplet fusion, cholesterol crystal granuloma and pulmonary alveolar proteinosis. The intra-alveolar eosinophilic material (multilamellated, lattice-shaped, and myelin-like structure) showed abnormal lamellar bodies (features of alveolar type Ⅱ epithelial cells) and abundant rough endoplasmic reticulum and mitochondria (features of fibroblasts) on transmission electron microscopy of the lung tissue from rats exposed to Nano-ITO on the 84th day. Cellular pathology revealed that a large amount of amorphous PAS stain-positive substances appear in BALF at 28 days post-exposure, and pink granular protein-like substances can be seen in alveolar macrophages. Conclusions: There are three characteristic developmental stages in Nano-ITO induced pulmonary injury in rats, acute inflammation, granuloma (nodule) formation and collagen proliferation, and pulmonary alveolar proteinosis, which provide a reference feature model for the pathogenesis of indium lung disease.

Research progress on T-cell immunity in patients infected with SARS-CoV-2

Patients with SARS-CoV-2 infection often exhibit significant changes in T cells, particularly a reduction in CD4+T and CD8+T cells in peripheral blood, which has become a key feature of severe respiratory infection. These immune changes in T lymphocytes are closely associated with disease progression, but the specific mechanisms remain unclear and warrant further investigation. This paper reviewed the changes in the number and function of T cells in respiratory viral infections, with a focus on SARS-CoV-2, and summarized related therapeutic explorations. We believe that improving and enhancing the number and function of T lymphocytes in infected hosts is a promising strategy for the treatment of respiratory viral infections, although more systematic and in-depth scientific research is still needed.

A collaborative cybersecurity framework for higher education

Purpose The purpose of this paper is to present the educational computer emergency response team (EduCERT) framework, an integrated response mechanism to bolster national cybersecurity through collaborative efforts in the higher education sector. The EduCERT framework addresses this gap by enhancing cyber security and mitigating cybercrime through collaborative incident management, knowledge sharing and university awareness campaigns. Design/methodology/approach The authors propose an EduCERT framework following the design science methodology. The framework is developed based on literature and input from focus group experts. Moreover, it is grounded in the principles of the technology-organization-environment framework, organizational learning and diffusion of innovations theory. Findings The EduCERT has eight components: infrastructure, governance, knowledge development, awareness, incident management, evaluation and continuous improvement. The framework reinforces national cybersecurity through cooperation between universities and the National Computer Emergency Response Team. The framework has been implemented in Jordan to generate a cybersecurity foundation for higher education. Evaluating the EduCERT framework’s influence on national cybersecurity highlights the importance of adopting comprehensive cyber-security policies and controls. The framework application shows its relevance, effectiveness, adaptability and alignment with best practices. Research limitations/implications Despite the impact of applying the framework in the Jordanian context, it is essential to acknowledge that the proposed EduCERT framework’s practical implementation may encounter challenges specific to diverse international educational environment sectors. However, framework customization for global applicability could address varied educational institutions in other countries. Practical implications Furthermore, the proposed EduCERT framework is designed with universal applicability that extends beyond the specific country’s context. The principles and components presented in the framework can serve as valuable design advice for establishing collaborative and resilient cybersecurity frameworks in educational settings worldwide. Therefore, the research enhances the proposed framework’s practical utility and positions it as an invaluable contribution to the broader discourse on global cybersecurity in academia. Originality/value This paper enhances national cybersecurity in the higher education sector, addressing the need for a more integrated response mechanism. The EduCERT framework demonstrates its effectiveness, adaptability and alignment with best practices, offering valuable guidance for global educational institutions.

The Use of STEAM Education Learning Package to Develop Elementary School Students’ Science Process Skills and Learning Achievement of Physical Properties of Materials

The Use of STEAM Education Learning Package to Develop Elementary School Students’ Science Process Skills and Learning Achievement of Physical Properties of Materials

Effects of two-person synchronized cycling exercise on interpersonal cooperation: A near-infrared spectroscopy hyperscanning study

ObjectiveAlthough psychological research indicating the synchronous activities can promote interpersonal cooperation, thus far there is no direct evidence that two-person synchronous exercise effectively enhances interpersonal cooperative behaviors in Physical exercise field. This suggests that, although synchronization phenomenon is widespread in sports and is considered a potential tool for enhancing teamwork, its specific effects and functioning mechanisms still need to be clarified by further scientific research. This study intends to use two-person synchronized cycling exercise to investigate the synchronized exercise effect on interpersonal cooperative behavior and its underlying neural mechanisms. MethodsEighty college students without regular exercise habits will be randomly assigned to the experimental group (10 male dyads and 10 female dyads) and the control group (10 male dyads and 10 female dyads). During the experiment, dyads in the experimental group performed a 30-minute synchronized cycling exercise with synchronized pedaling movements; dyads in the control group rested sedentary in the same environment for 30 minutes. Interpersonal cooperative behavior was assessed with the Prisoner's Dilemma task, and the interpersonal neural synchronization(INS) data were collected in the prefrontal cortex using near-infrared hyperscanning. ResultsThis study compared behavior and brain activity before and after synchronous exercise. Behavioral results revealed that, compared to pre-exercise, dyads in the post-exercise had higher average cooperation rates, higher cooperation efficiency and shorter cooperation response times. Compared to post-sedentary, dyads in the post-exercise had shorter cooperation response times and higher cooperation efficiency. Furthermore, brain data showed that,compared to pre-exercise, dyads in the post-exercise had stronger INS in the dorsolateral prefrontal cortex(DLPFC), whereas the dyads in the post-exercise had stronge INS in the DLPFC compared to post-sedentary. After controlling for dyads' anxiety and mood states, this study also found a marginally significant negative correlation between INS differences in the left DLPFC and cooperation response time differences. ConclusionsThis research confirms, from both behavioral and neuroscience perspectives, that one synchronization cycle can significantly enhance interpersonal cooperative behavior, and this positive effect is closely associated with increased INS in the left DLPFC. This study provides new insights into understanding how positive interactive exercises promote interpersonal cooperation through specific neural mechanisms.

High-dose vitamin C as a metabolic treatment of cancer: a new dimension in the era of adjuvant and intensive therapy.

The anti-cancer mechanism of High-dose Vitamin C (HDVC) is mainly to participate in the Fenton reaction, hydroxylation reaction, and epigenetic modification, which leads to the energy crisis, metabolic collapse, and severe peroxidation stress that results in the proliferation inhibition or death of cancer cells. However, the mainstream view is that HDVC does not significantly improve cancer treatment outcomes. In clinical work and scientific research, we found that some drugs or therapies can significantly improve the anti-cancer effects of HDVC, such as PD-1 inhibitors that can increase the anti-cancer effects of cancerous HDVC by nearly three times. Here, the adjuvant and intensive therapy and synergistic mechanisms including HDVC combined applicationof chemoradiotherapies multi-vitamins, targeted drugs, immunotherapies, and oncolytic virus are discussed in detail. Adjuvant and intensive therapy of HDVC can significantly improve the therapeutic effect of HDVC in the metabolic treatment of cancer, but more clinical evidence is needed to support its clinical application.