Layered double hydroxides (LDHs) which are one type of layered material are promising materials due to some of their interesting properties, such as ease of synthesis, unique structure, uniform distribution of different metal cations in the brucite layer, surface hydroxyl groups, flexible tunability, intercalated anions with interlayer spaces, swelling properties, and high chemical and thermal stability, ability to intercalate different type of anions, and also high biocompatibility. This review article is focused on more information about synthesis methods of layered double hydroxides, and their applications in many fields. The most common synthesis methods for layered double hydroxides are co-precipitation, urea hydrolysis, hydrothermal synthesis, sol-gel, reconstruction, etc. are discussed. LDHs shows excellent performance as a multifunctional material for its promising applications in the fields of catalysts, water treatment, flame retardants, polymer additivies, adsorbents, nuclear industry, environmental protection, photocatalysts, and material science.