Background. The modern medical community considers the quality of life assessment as the main and reliable tool for population-based health surveys, which are extremely relevant in the context of the persistence of the negative trend of its deterioration among school children. Most of the questionnaires are designed for children with pathological conditions, and studies of relatively healthy children are few and relate mainly to aspects of the level of physical activity and sports, and do not take into account the impact of the educational process.
 Aim: to determine the dynamics of changes in the quality of life associated with the health of primary school children in the learning process by quantitative and qualitative characteristics
 Material and methods. A prospective study was conducted over four school years through a survey using an adapted Ukrainian-language questionnaire for primary school students (624 children aged 7-11) and their parents (616 people). T-test, multiple correlations and one-way analysis of variance in the licensed software package IBM SPSS Statistics v.20.0, graph-models of correlation structures and their system analysis were used for statistical data processing.
 Results. The influence of gender, age, and year of study on the scale of relationships with peers, the probable increase in the 4th grade of school activity according to children, and vice versa, its decrease according to the parental version were revealed. The highest level of quality of life is set on the scale "Emotional activity", and the lowest - on school activities and relationships with adults. During the first two years of study, the main system-forming structures were emotional and physical activities, and in old age, school activity became more important. The largest qualitative differences like the links between the second and third year of the study indicated that this period of study was critical for children, and the reduction in the labilization rate indicated sufficient compensation.
 Conclusions. According to the study of the quality of life associated with health in the 4-year dynamics of learning, the most critical period was the transition from the second to the third grade with the preservation of a synchronized system of self-assessment of their condition. The level of physical, emotional and social functioning had certain gender and age characteristics and depended to a greater extent on the period of the educational process. The scales of school activity and socialization in their age group were especially influenced. The study found inconsistency in the perception of school life and satisfaction with communication between children and adults.