Objective: To understand the research hotspots and development trends of binary coping in chronic disease patients and their spouses, and to provide ideas and references for future related research. Methods: Literature on binary coping in patients with chronic diseases and their spouses included in the Web of Science Core Collection database was analysed visually in terms of the number of articles, countries and keywords using CiteSpace software. Results: A total of 4138 valid articles were included, and the country with the largest number of articles was the United States. The main research populations were breast cancer, dementia, and prostate cancer patients and their spouses; and the research hotspots were quality of life, diabetes, stroke, and multimorbidity, etc. Conclusion: Most of the intervention studies on the dyadic coping of patients with chronic diseases and their spouses are in developed countries, and scholars in China can learn from the international research hotspots, combine with China's national conditions, and construct a management program suitable for the cultural needs and psychological needs of chronic disease patients and their spouses in China.