Schiff Base Metal Complexes Research Articles

Synthesis, Structural Elucidation, Cytotoxic activity and Plant Growth Studies of Some Novel Schiff Base Cobalt(II) and Nickel(II) Complexes of Sulfur/Oxygen and Nitrogen Donor Agents

Eight metal complexes with Schiff base ligands, HL1 [2-{1-(2-fluorophenyl)ethyledene}] hydrazinecarboxamide and HL2 [2-{1-(2-fluorophenyl)ethyledene}] hydrazinecarboxathioamide were synthesized with Co(II) and Ni(II). These were characterized by analytical as well as various spectroscopic techniques like FT-IR, 1H NMR, electronic absorption spectra. The spectral results revealed the formation of octahedral complexes. To determine the concentration of cobalt in Schiff base metal complex flame atomic absorption spectroscopy (FAAS) was done. The accuracy of results was verified by inductively coupled plasma mass spectroscopy (ICP-MS). In vitro cytotoxic activity of the ligands HL1, HL2 and their Schiff base metal complexes was examined, in which A549 (human lung cancer cell line) and L929 (mouse normal fibroblast cell line) were used in the screening test. Among all the synthesized Schiff base ligands and metal complexes, Ni(II) thiosemicarbazone based complex i.e. (Ni (L2)2.2H2O) exhibited a significant cytotoxic effect towards A549 cell line with a mean IC50 value of 36.43 μΜ. Plant growth regulatory activity of the ligands (HL1, HL2) and their metal complexes have also been performed on chick pea plant. The PGR activity of the ligands and their complexes were compared and it was found that the thiosemicarbazone based metal complexes possess higher PGR activity.

Photofunctions in Hybrid Systems of Schiff Base Metal Complexes and Metal or Semiconductor (Nano)Materials.

Composite materials very often provide new catalytic, optical or other physicochemical properties not observed for each component separately. Photofunctions in hybrid systems are an interesting topic of great importance for industry. This review presents the recent advances, trends and possible applications of photofunctions of hybrid systems composed of Schiff base metal complexes and metal or semiconductor (nano)materials. We focus on photocatalysis, sensitization in solar cells (DSSC—dye sensitized solar cell), ligand-induced chirality and applications in environmental protection for Cr(VI) to Cr(III) reduction, in cosmetology as sunscreens, in real-time visualization of cellular processes, in bio-labeling, and in light activated prodrug applications.

Synthesis and Characterization of Schiff Bases and Cu(II) and Ni(II) Complexes of Polyhedral Oligomeric Silsesquioxane (POSS) Compounds

Bu çalışmada, 3-aminopropiltrietoksisilan (APTES) ve N-(2-aminoetil)-3-aminopropiltrimetoksisilan (AEPTMS) kullanılarak iki farklı polihedral oligomerik silseskioksan (POSS) sentezlenmiştir. Elde edilen bu POSS bileşikleri, salisilaldehit ve 5-bromosalisilaldehit ile kondenzasyon tepkimesi sonucu POSS Schiff bazları sentezlenmiştir. POSS ve ligand özelliğindeki türevlerinin yapıları spektroskopik (Elementel analiz (C, H, N), 1H-NMR, 29Si NMR, FT-IR) yöntemlerle aydınlatılmıştır. Schiff Bazlarının Cu(II) ve Ni(II) metal kompleksleri sentezlenmiştir. İzole edilen POSS Schiff bazı metal komplekslerinin yapıları FT-IR, Magnetik duyarlılık terazisi ve ICP-OES ile aydınlatılmaya çalışılmıştır. Sonuçlar, metal iyonlarının Schiff bazlarına fenolik oksijen ve azometin azotu üzerinden bağlandığını göstermiştir.

Synthesis, spectral, antioxidant, in vitro cytotoxicity activity and thermal analysis of Schiff base metal complexes with 2,2′-Bipyridine-4,4′-dicarboxylic acid as co-ligand

The Schiff base ligand (H2L1) [H2L1 = (E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)-methylene) benzo hydrazide] and its metal (II) complexes of molecular formula [Co(H2L1)(L2)], [Ni(H2L1)(L2)], [Cu(H2L1)(L2)], [Zn(H2L1)(L2)], [Cd(H2L1)(L2)], where, L2 = 2,2′-Bipyridine-4,4′-dicarboxylic acid as co ligand were synthesized and characterised using various analytical techniques. Based on spectral analysis, the complexes are found to be square pyramidal and also the coordinating sites of the complexes are azomethine nitrogen, two phenolic oxygen from Schiff base ligand (H2L1) and two nitrogen from 2,2′-Bipyridine-4,4′-dicarboxylic acid. The antimicrobial activity of the ligand and complexes was determined by testing them against bacterial pathogens and fungal strains. All the synthesized complexes were more active than the free chelate against the tested microorganisms. According to our findings, the antioxidant activity of complexes by the DPPH method is concentration-dependant and better than the free ligand H2L1. Compared to the therapeutically utilised Sorafenib (Nexavar), the metal complexes and its H2L1 ligand displayed stronger cytotoxicity against the human breast cancer MCF -7 cell lines. The [Co(H2L1)(L2)] complex showed promising anticancer activity with IC50 3.5 μg/mL. Cell death is due to apoptosis in MCF-7 cells and the formation of ROS by the Schiff base ligand H2L1 and its derived metal complexes.

Synthesis, Characterization, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes

The condensation of aromatic aldehyde with amine results in the formation of Schiff's bases, which are considered to be one of the most significant groups of ligands. Schiff's base metal complexes have received a lot of attention because of their high biological activity. Such include antimicrobial, anticancer, antibacterial, and antifungal activities. The current research is focused on the synthesis and characterization of two Schiff's base ligands obtained from the reaction of isoniazid with 4-(N,N-dimethylamino)benzaldehyde (L1) and 5-nitro-2-furfurldehyde (L2), respectively and their metal complexes with Cu2+, Zn2+, and Ni2+ ions. FT-IR, UV-Vis, conductivity, and magnetic susceptibility (µeff) measurements were used to describe the ligands (L1 and L2) and their complexes. The square planar geometry of Cu2+ and Ni2+ complexes, as well as the tetrahedral geometry of Zn2+ complexes, are supported by the Uv-Vis spectra and magnetic moments data. Their antibacterial effectiveness against various pathogenic microorganisms was evaluated in the presence of standard Kanamycin-30. The CuL2 complex, among all the metal complexes derived from the L2 ligand, exhibited better antibacterial activity against S. aureus than that of Kanamycin-30. When compared to the BHT antioxidant, all Cu2+ complexes showed excellent efficacy.

Syntheses, Structures and Biological Activity of Some Schiff Base Metal Complexes

Four new binuclear Schiff base metal complexes [(MCl2)2L] {M = Fe 1, Co 2, Cu 3, Sn 4, L = N,N’-1,4-Phenylenebis (methanylylidene) bis (ethane-1,2-diamine)} have been synthesized using direct reaction between proligand (L) and the corresponding metal chloride (FeCl2, CoCl2, CuCl2 and SnCl2). The structures of the complexes have been conclusively determined by a set of spectroscopic techniques (FT-IR, 1H-NMR, and mass spectra). Finally, the biological properties of the complexes have been investigated with a comparative approach against different species of bacteria (E. coli G-, Pseudomonas G-, Bacillus G+, Staphylococcus G+, and Streptococcus G+).

Preparation of co-schiff base complex and its adsorption desulfurization

Twelve schiff base metal complexes were synthesized, and selected to adsorption desulfurization of dibenzothiophene(DBT). The result showed that the schiff base metal complex of melamine and cobalt (SF-S/Co) was the optimal adsorbent. Then SF-S/Co was characterized by scanning electron microscopy(SEM), Brunner − Emmet − Teller(BET) measurements, fourier transform infrared spectroscopy(FTIR), X-ray diffraction, and energy spectroscopy analysis. The effects of adsorbent amount and adsorption time on adsorption desulfurization were studied. The optimal adsorption condition was 1.5 g adsorbent/100 mL model oil, and the adsorption time was 8 min at room temperature. Under the optimal condition, the adsorption removal rate of DBT is up to 95%. The maximum adsorption capacity of the adsorbent for DBT is 21.66 mg/g. The adsorption capacity of adsorbent didn’t decreased obviously after being reused for 5 times. The adsorption isothermal model and dynamics of the adsorption process was further studied. The results show that the adsorption process of DBT by this adsorbent followed the Freundlich adsorption isothermal model and the pseudo-second-order model kinetics. The absorption effect of this adsorbent on different sulfides also was investigated. The order of removal efficiency was: dibenzothiophene > benzothiophene > thiophene.

Synthesis, characterization, biological and catalytic activity of carboxymethyl chitosan schiff base metal complexes

The Schiff base of carboxymethyl chitosan/p-dimethylaminobenzaldehyde (CMC-SB), as well as its complexes with cobalt (CMC-SB-Co), nickel (CMC-SB-Ni), and zinc (CMC-SB-Zn), were synthesised and studied using FTIR, XRD, TGA, DSC, and SEM. Schiff base metal complex production has been verified by the FTIR and XRD data. According to the thermal studies, the CMC-SB Zinc combination has better thermal stability than other complexes. The material is porous and rough, and the SEM results show that it has several potential uses in the biological field. The zinc complexes have increased activity when it comes to catalysis. It has been determined by the MTT test and ALP activity that the synthesised sample is non-toxic, compatible, and has good antioxidant activity.

Synthesis, spectroscopic, in vitro, in silico, and in vivo studies of binuclear Cu (II), Ni (II), Ru (II), and Zn (II) complexes with tetradentate Schiff base ligand

AbstractA novel Schiff base macrocyclic ligand was synthesized by the condensation of 4‐(3,4‐diaminophenyl)benzene‐1,2‐diamine with β‐naphthol‐1‐aldehyde. Binuclear complexes were synthesized from this Schiff base by reaction with Cu (II), Ni (II), Ru (II), and Zn (II) metal salts. Square planar geometrical structures of Cu (II), Ni (II), and Ru (II) complexes were achieved by several physicochemical methods, namely UV–Vis, FT‐IR, NMR, ESI‐Mass, and thermogravimetric analysis, respectively. Density functional theory (DFT) calculations at the B3LYP/6‐31G(d) level were carried out to gain an insight into the thermodynamic stability and biological accessibility of the complexes. Moreover, molecular docking analysis was done against a novel target protein PDB: 6M71 (SARS‐CoV‐2). Both the Schiff base ligand and metal complexes showed excellent interaction with protein receptor. All the metal complexes have the strong tendency to undergo intercalation mode of binding with CT DNA. All the in vivo and in vitro screening studies showed that the complexes exhibit higher activities than the free Schiff base.

Synthesis, spectral characterization, and biological studies of Schiff bases and their mixed ligand Zn(II) complexes with heterocyclic bases

In the present study, six mononuclear Zinc(II) complexes, [Zn(L1)(6-Methyl-2,2′-bpy)] (1), [Zn(L1)(1,10-Phen)] (2), [Zn(L1)(5-Amino-1,10-Phen)] (3), [Zn(L2)(6-Methyl-2,2′-bpy)] (4), [Zn(L2)(4,4′-Di-tert-butyl-2,2′-bpy)] (5), and [Zn(L2)(1,10-Phen)] (6) formed from Schiff bases, 2-methyl-1-phenyl-1-(pyridin-2-ylmethylimino)propan-2-ol (L1) and 4-chloro-5-methyl-2-(1-(pyridin-2-ylmethylimino)ethyl)phenol (L2) were synthesized. The synthesized Schiff base ligands and metal complexes were characterized by different spectroscopic techniques such as FTIR, UV–Visible, 1H & 13C NMR spectroscopy, in addition to Powder X-ray diffraction and cyclic voltammetry. Further, the synthesized metal complexes (1–6) and their parental Schiff bases (L1, L2) were evaluated for antibacterial, antifungal, and antioxidant activities. Of those, Complex 1 was shown to have significant antibacterial activity against all of the evaluated microorganisms. Schiff base ligands, L1 and L2, complexes 1, 4, and 5 were shown to have superior antifungal activity against Aspergillus niger than the standard drug, fluconazole. In addition, the synthesized compounds achieved good antioxidant activities when compared to the standard Ascorbic acid.

Efficacy of a multi-dentate Schiff base and its vanadyl complex on various morphological and biochemical parameters of Vigna radiata L.

A N2O2 donor Schiff base polydentate ligand was synthesized by the condensation of benzidine and benzil in ethanolic medium. The formed ligand was condensed further with VOSO4.xH2O to get the corresponding vanadyl complex. Both the ligand and the complex were characterized by spectroscopic and elemental analyses. Mung bean (Vigna radiata L.) was selected as a plant material. Various morphological and biochemical parameters, e.g. leaf senescence assay, chlorophyll content, and different reactive oxygen species (ROS) were estimated and were compared to those with ammonium vanadate. Outcomes of the experiments revealed that the Schiff base complex has less toxic effects than ammonium vanadate on mung bean seedlings and provide better tolerance to vanadium toxicity. Though different stress marker and ROS accumulation were less and minimum pigment damage was noticed in the Schiff base complex-treated seedlings but the optimum positive impact largely depends on the dose. Beyond certain concentration, the complex may show inhibitory effects on the plants. Therefore, the present study revealed that heavy metal Schiff base complexes can be used as potential supplement to meet up micronutrient deficiency and at the same time such complexes can minimize the toxicity generated by application of different heavy metals.

Synthesis, Characterization and Antimicrobial Study of Chitosan Schiff Base Derivatives

Chitosan is natural, biodegradable, and biocompatible hydrophilic polysaccharide of â(1-4)-linked Dglucosamine and N-acetyl-D-glucosamine prepared from chitin. The remarkable biological properties have paved the way for the introduction of chitosan in the biomedical and pharmaceutical fields. Chitosan, a bio-based polymer which has similar characteristics to those of cellulose, exhibits cationic behaviour in acidic solutions and strong affinity for metals ions. Various chemical modifications have been investigated to improve the properties of chitosan and thus to increase its range of applications. The antimicrobial activity of chitin , chitosan and their derivatives against different groups of microorganisms such as bacteria, yeast and fungi has received considerable attention in the present time. Keeping in view the ample potentials of the antimicrobial activity of chitosan, we have made an attempt to prepare, a Chitosan-base Schiff-based (CSB) compound with an aromatic substituent group. This was synthesized by the reaction of Chitosan with an aromatic aldehyde p-dimethylaminobenzaldehyde. The Chitosan-based Schiff base metal complexes were subsequently obtained through the reaction of newly synthesized Schiff bases with metal chlorides. The obtained products were characterized by Fourier transform infrared (FTIR) spectroscopy. The antifungal activity of Chitosan Schiff base and its metal complexes were measured against Rhizopus fungus and antibacterial activity against Gram positive and Gram negative bacteria. These results show that it has both antifungal and antibacterial activity. Chitosan Schiff metal complex have higher antibacterial activity against gram positive and gram negative bacteria.

Novel thioether Schiff base transition metal complexes: Design, synthesis, characterization, molecular docking, computational, biological and catalytic studies

A series of novel copper(II), nickel(II), zinc(II) and cobalt(II) Schiff base metal complexes were synthesized by the reaction of 2‐(benzylthio) aniline with pyrrole‐2‐carboxaldehyde and characterized by FT‐IR, UV–visible, elemental analyses, 1H‐NMR, magnetic susceptibility and ESI‐MS. The Schiff base ligand posed as an NS‐bidentate ligand, confirming the synthesis of metal complexes with the suggested structure, according to the spectrum analysis data. All the complexes acquire square planar geometry. Furthermore, the DFT method was utilized to conduct computational analyses of metal complexes. The spectroscopic (UV–Vis and fluorescence) techniques were employed to probe the binding nature of calf thymus‐DNA binding to metal complexes. The metal complexes interact with DNA through intercalative mode, according to the spectroscopic titration data. The antioxidant properties of metal complexes were evaluated using their reducing ability and free radical scavenging activity of DPPH. The antioxidant property is high in isolated complexes. The in vitro anti‐inflammatory efficacy of all complexes has also been studied. All the metal complexes exhibited effective anti‐inflammatory activity and can be used as synthetic drugs. The synthesized copper(II) complex exhibits excellent catalytic activities for the transformation reaction of alcohol to aldehyde in the presence of hydrogen peroxide. The interaction of metal complexes with active sites of the B‐DNA (1‐BNA) and 6‐COX (COX 2) was studied using docking studies.

Solution Equilibrium Studies on Salicylidene Aminoguanidine Schiff Base Metal Complexes: Impact of the Hybridization with L-Proline on Stability, Redox Activity and Cytotoxicity.

The proton dissociation processes of two tridentate salicylidene aminoguanidine Schiff bases (SISC, Pro-SISC-Me), the solution stability and electrochemical properties of their Cu(II), Fe(II) and Fe(III) complexes were characterized using pH-potentiometry, cyclic voltammetry and UV-visible, 1H NMR and electron paramagnetic resonance spectroscopic methods. The structure of the proline derivative (Pro-SISC-Me) was determined by X-ray crystallography. The conjugation of L-proline to the simplest salicylidene aminoguanidine Schiff base (SISC) increased the water solubility due to its zwitterionic structure in a wide pH range. The formation of mono complexes with both ligands was found in the case of Cu(II) and Fe(II), while bis complexes were also formed with Fe(III). In the complexes these tridentate ligands coordinate via the phenolato O, azomethine N and the amidine N, except the complex [Fe(III)L2]+ of Pro-SISC-Me in which the (O,N) donor atoms of the proline moiety are coordinated beside the phenolato O, confirmed by single crystal X-ray crystallographic analysis. This binding mode yielded a stronger Fe(III) preference for Pro-SISC-Me over Fe(II) in comparison to SISC. This finding is also reflected in the lower redox potential value of the iron-Pro-SISC-Me complexes. The ligands alone were not cytotoxic against human colon cancer cell lines, while complexation of SISC with Cu(II) resulted in moderate activity, unlike the case of its more hydrophilic counterpart.

Synthesis, characterization, in vitro, in silico and in vivo investigations and biological assessment of Knoevenagel condensate β-diketone Schiff base transition metal complexes

A novel Schiff base ligand was synthesized by the Knoevenagel condensation of β-diketone (obtained from substituted Curcumin and Cuminaldehyde) and 4-amino antipyrine. Metal complexes were made from this Schiff base by reacting with metal salts such as Cu(II), Ni(II), Ru(III), VO(IV), and Ce(IV). Physicochemical approaches such as UV-Vis, FT-IR, NMR, EPR, and Mass spectroscopy were used to determine the geometry of the complexes. The thermodynamic stability and biological accessibility of the complexes were investigated using density functional theory (DFT) calculations at the B3LYP/6-31G(d) level. A molecular docking analysis was also performed on 1BNA receptor. Both the Schiff base ligand and metal complexes interacted well to this protein receptor. All metal complexes have a significant potential to bind to CT DNA via the intercalation mechanism. All the in vivo and in vitro screening studies showed that the complexes exhibit higher activities than the free Schiff base. Communicated by Ramaswamy H. Sarma

2-(4-nitrophenyl)iminomethyl phenol Schiff base metal complexes: Synthesis, spectroscopic characterization, anticancer and antimicrobial studies

An imine-based molecule, 2-(4-nitrophenyl)iminomethyl phenol Schiff base (NPIMP) ligand was synthesized by microwave and conventional methods by reaction between 4-nitroaniline (1) and salicyaldehyde (2). The metal complexes of La(III), Co(II), Ni(II) and Cu(II) (3a-d) with NPIMP were synthesized as potential anticancer and antimicrobial drug candidates. The synthesized ligand and metal complexes were structurally characterized by spectral (NMR, FT-IR, LC-MS and UV-Vis), scanning electron microscopy, elemental analysis, powder X-ray diffraction and thermo gravimetric (TG) data. Spectroscopic studies suggested a distorted octahedral structure for all the complexes. The systems were evaluated for their anticancer and antimicrobial activities. The anticancer activity studies revealed that all the complexes exhibited promising activity against MCF-7 breast and HeLa cell lines. Antimicrobial activity has shown that all the complexes were showed certain degree of activity. As for the antimicrobial activity, La(III) and Co(II) complexes displayed potential antibacterial and antifungal activity against the tested microbes.

Biologically important Schiff base–metal complexes derived from arginine and curcumin derivatives

Biologically important Schiff base–metal complexes derived from arginine and curcumin derivatives

Biochemical Characterization of New Gemifloxacin Schiff Base (GMFX-o-phdn) Metal Complexes and Evaluation of Their Antimicrobial Activity against Some Phyto- or Human Pathogens.

Four novel ligand-metal complexes were synthesized through the reaction of Fe(III), pleaseCo(II), Zn(II), and Zr(IV) with Schiff base gemifloxacin reacted with ortho-phenylenediamine (GMFX-o-phdn) to investigate their biological activities. Elemental analysis, FT-IR, 1H NMR, UV-visible, molar conductance, melting points, magnetic susceptibility, and thermal analyses have been carried out for insuring the chelation process. The antimicrobial activity was carried out against Monilinia fructicola, Aspergillus flavus, Penicillium italicum, Botrytis cinerea, Escherichia coli, Bacillus cereus, Pseudomonas fluorescens, and P. aeruginosa. The radical scavenging activity (RSA%) was in vitro evaluated using ABTS method. FT-IR spectra indicated that GMFX-o-phdn chelated with metal ions as a tetradentate through oxygen of carboxylate group and nitrogen of azomethine group. The data of infrared, 1H NMR, and molar conductivity indicate that GMFX–o-phdn reacted as neutral tetra dentate ligand (N2O2) with metal ions through the two oxygen atoms of the carboxylic group (oxygen containing negative charge) and two nitrogen atoms of azomethine group (each nitrogen containing a lone pair of electrons) (the absent of peak corresponding to ν(COOH) at 1715 cm−1, the shift of azomethine group peak from 1633 cm−1 to around 1570 cm−1, the signal at 11 ppm of COOH and the presence of the chloride ions outside the complex sphere). Thermal analyses (TG-DTG/DTA) exhibited that the decaying of the metal complexes exists in three steps with the final residue metal oxide. The obtained data from DTA curves reflect that the degradation processes were exothermic or endothermic. Results showed that some of the studied complexes exhibited promising antifungal activity against most of the tested fungal pathogens, whereas they showed higher antibacterial activity against E. coli and B. cereus and low activity against P. fluorescens and P. aeruginosa. In addition, GMFX-o-phdn and its metal complexes showed strong antioxidant effect. In particular, the parent ligand and Fe(III) complex showed greater antioxidant capacity at low tested concentrations than that of other metal complexes where their IC50 were 169.7 and 164.6 µg/mL, respectively.

Effects of solvent composition on the synthesis of polydopamine Schiff base Cu complex to activate peroxymonosulfate for methyl-paraben degradation

Solvent composition plays an important role in the synthesis of metal complex materials, but to date little work on this issue has been reported. Herein, a unique Schiff base Cu complex catalyst (DPDA-Cu-95EtOH) was designed based on polydopamine (PDA) and 3, 5-dibromosalicylaldehyde (DBSA), and the influence of H2O added during the synthesis process on its catalytic performance towards peroxymonosulfate (PMS) activation was comprehensively investigated. Our results demonstrated that adding a small amount (5%, v:v) of H2O to the solvent absolute ethanol (EtOH) can greatly increase the Cu loading (from 3.56 at% to 10.30 at%) on the catalyst, which significantly enhanced its catalytic ability, and promoted the removal of MeP for about 4.6 times higher than that synthesized without addition of H2O. Electron paramagnetic resonance (EPR) and quenching tests revealed that 1O2, OH and SO4- were responsible for the degradation of Methyl-paraben (MeP). Moreover, the DPDA-Cu-95EtOH/PMS system not only showed excellent stability and reusability, but also exhibited considerable removal efficiency of MeP in real wastewater. Overall, this study provides new insights into the controllable synthesis of Schiff base metal complex used for the efficient activation of PMS to remove micropollutants in wastewater.

Synthesis of new Schiff base and its Ni(II), Cu(II), Zn(II) and Co(II) complexes; photophysical, fluorescence quenching and thermal studies

In this study, a new Schiff base ligand, that was obtained from the condensation reaction of 1,10-phenanthrolin-5-amine with 4-fluorobenzaldehyde, and its novel stable series of Schiff base metal complexes (M = Ni(II), Cu(II), Zn(II), Co(II)) were synthesized in suitable conditions to contribute to increase anticancer drug activity in drug transport systems. The new compounds have been characterized using FT-IR, UV-Vis, 1H NMR, LC-MS and elemental analysis. The thermal stabilities of these complexes were studied by applying thermogravimetric (TGA/DTA) and the related decomposition steps were investigated. The TGA measurements were carried out to determine the effect of metals on the thermal strength of the newly synthesized complexes. The Cu(II) complex exhibited higher thermal strength. The photophysical properties of the Schiff base ligand and its metal complexes were studied in different solvents such as DMF, DMSO, methanol and ethanol. Dynamic quenching constant (KSV) values of the compounds as important parameters for biological systems in fluorescence quenching studies were calculated and the highest KSV value (17.42) was obtained for compound 6 in DMSO, however, the highest KSV value (7.80) was determined for compound 3 in DMF. The KSV values of the Schiff base ligand and its zinc complex were higher than those that have been reported in the literature. Due to the high KSV values of these compounds (3 and 6), they can be listed as anticancer drug active ingredients in drug transport systems.