Abstract
Four new binuclear Schiff base metal complexes [(MCl2)2L] {M = Fe 1, Co 2, Cu 3, Sn 4, L = N,N’-1,4-Phenylenebis (methanylylidene) bis (ethane-1,2-diamine)} have been synthesized using direct reaction between proligand (L) and the corresponding metal chloride (FeCl2, CoCl2, CuCl2 and SnCl2). The structures of the complexes have been conclusively determined by a set of spectroscopic techniques (FT-IR, 1H-NMR, and mass spectra). Finally, the biological properties of the complexes have been investigated with a comparative approach against different species of bacteria (E. coli G-, Pseudomonas G-, Bacillus G+, Staphylococcus G+, and Streptococcus G+).
Highlights
Over decades Schiff base continue attracts antibiotic designer’s attention because of distinctive chelating features 1
Scientists have been employed Schiff base in a wide range of medical applications such as antibacterial [6, 7], antifungal 8, antitumor 9, antiviral 10, anti-HIV 11, herbicidal 12, and anti-influenza virus 13. In light of these medical facts, we present the synthesis, spectroscopic characterization and biological activity of a series of Schiff base metal complexes [1,2,3,4]
The main objective of the present work was to find the antibacterial activity of these Schiff base metal complexes toward six different pathogens
Summary
Over decades Schiff base continue attracts antibiotic designer’s attention because of distinctive chelating features 1. Antibacterial activity of such ligand containing donor atoms can be enhanced significantly by coordination to a metal ion [2, 3, 4]. Scientists have been employed Schiff base in a wide range of medical applications such as antibacterial [6, 7], antifungal 8, antitumor 9, antiviral 10, anti-HIV 11, herbicidal 12, and anti-influenza virus 13. Chemical analysis evidence allows proposing a binuclear aggregation mode for these MII complexes of tetradentate Schiff-bases
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