Despite the strong interest concerning the responsive façades, today there are still few built examples and few tools to assess their benefits due to the complex description of the phenomenon. Energy simulations should consider the interactions between a time-varying environment and an environment-dependent envelope, increasing the intricacy of the problem; moreover, these strong environment–envelope interlinkages increase the importance of the location and climate scenarios considered. The aim of this study is to provide a tool to easily model these phenomena in different geographical and climate contexts. For this purpose, an innovative interactive computational platform (ICP) was developed based on EnergyPlus as a simulation engine, Python as a simulation manager, and Grasshopper as a user interface. Thanks to a single user-friendly environment, the users can simply select the climate scenario, the location, the responsive technology, and its main properties to set and run the dynamic energy simulation. After an overview of the current state of the art, this study provides a description of the structure and workflow adopted for developing this platform and details regarding its functioning and input management. Finally, the platform was tested to run an evolutionary optimization of an electrochromic window control strategy in different climate scenarios.