To improve the forming quality of overhanging round hole parts without support, the effects of different processing parameters on the forming quality of the structure were investigated by numerical simulation and experiment. The response surface method was used to analyze the collapse of the overhanging surface. A quadratic response model was established, which can be used to predict the optimization of processing parameters. Finally, three groups of parts under different processing parameters were fabricated by SLM, and the forming quality of the parts was analyzed from the macroscopic and microcosmic perspectives. The results showed that the roundness, the collapse of the overhanging surface and the surface roughness increased with the increase of laser power. The result of increasing scanning speed was opposite. With the increase of scanning spacing, the surface roughness decreased continuously, and the roundness and collapse of the overhanging surface increased first and then decreased. When the scanning spacing was 0.15 mm, the roundness and collapse of the overhanging surface reached the minimum. With the increase of the three, the density and hardness increased first and then decreased. The results of response surface analysis were in good agreement with the experimental results.