Vascular illnesses include a spectrum of disorders affecting the blood vessels and continue to be major global health challenges. Vascular disorders are major worldwide health concerns that require ongoing development of drug screening models in order to find efficient treatment approaches. The ever-changing field of vascular health demands novel ways to medication screening due to the enduring difficulties presented by a variety of illnesses. This abstract explores a paradigm shift, highlighting the innovative role of the Temporal Convolutional Transformer (TCT) in redefining drug screening techniques and promoting model evolution. With its seamless integration of transformer mechanisms and temporal convolutional layers, the TCT is a revolutionary hybrid algorithm. Because of this special combination, the model can simultaneously identify spatial subtleties and capture temporal dynamics in complicated biological information. The temporal convolutional layers of the TCT are particularly good at revealing the sequential dependencies that are present in the development of vascular disorders. The model ensures a detailed knowledge of the developing nature of these diseases by analyzing temporal dynamics with skill. Simultaneously, the TCT’s transformer mechanisms enable a thorough examination of long-range interdependence and global interconnections. The TCT’s dual capability establishes it as a comprehensive solution by offering a nuanced perspective on spatial patterns that are essential for identifying the complexity of vascular health. The TCT is hybrid in the sense that it can learn features at several scales, supporting different temporal and spatial resolutions. This flexibility guarantees that the model may extract pertinent information at various scales, enhancing the characterization of the complex nature of vascular illnesses. The TCT is positioned as a holistic solution since its transformer mechanisms allow for a thorough investigation of long-range dependencies and global interconnections at the same time. This combined capacity offers a sophisticated viewpoint on spatial patterns that is essential for understanding the intricacies of vascular health. Moreover, the remarkable flexibility of the TCT to dynamic temporal scales is consistent with the dynamic character of biological processes, providing a strong and adaptable framework for drug screening. The TCT is used in many different fields of vascular disease research. The model performs well in image-based screening, collecting sequential dependencies over time and processing spatial information from medical imaging datasets. The TCT’s capacity to identify long-range dependencies is essential for molecular interaction research since it helps to clarify the complex pathways associated with vascular disorders. Its adaptability also extends to personalized treatment approaches, which allow for the efficient modeling of patient-specific data, including genetic information. The TCT is a revolutionary tool that will continue to evolve as drug screening models do. By integrating temporal convolutional and transformer mechanisms, its all-encompassing methodology provides a sophisticated and comprehensive approach to deciphering the intricacies of vascular disorders. Across all evaluated metrics, the proposed method achieves near-perfect accuracy of 98.45%, sensitivity of 93.45%, specificity of 98.43%, precision of 84.25, AUC of 99 % and F1 score values 96.01%, respectively. This abstract sheds light on how the TCT has significantly changed drug development approaches, opening the door for more focused and effective therapies in the field of vascular health.