As the increase of the capacity of power source, the scale of power grid and load, and the internal and external factors of security and economy on large-scale grid, understanding of the interactions and effects of power source, power grid and load, has very important significance for establishing the evaluation theory system of the adaptability of large-scale power grid. In the aspect of construction and investment, power source, power grid and load belong to different; in the aspect of opration and income, the three must comply with uniform guidelines for the regulation of the power system, and their incomes for each connect by electricity and price. For the problems of investments and incomes of power source, power grid and load, the paper establishs models of substation capacity, generator capacity, load capacity and the relationship of their investment and income based on game theory; the paper also proposes investment and income algorithm of power source, power grid, and load based on the ISO scheduling model. Numerical result demonstrates the effectiveness of game models and the algorithm, at the same time, it also analyses the interaction and influence and finds Nash equilibrium point among power source, power grid and load. These explain behaviors of power source, power grid and load respectively. The evaluation of adaptability among power source, power grid and load is an important part of the evaluation of large scale power grid, the research work and achievements of this paper can analyse the interaction and influence among power source, power grid and load, and calculate the income of each investor under a variety of strategies. And these provide the basis for each investors decision.