The collection of pulse signals is accompanied by considerable noise interference, and it is necessary to denoise the collected signals to eliminate the error brought about by the outside world and the instrument itself to the actual data to the greatest extent. Considering this, this article proposes a preprocessing scheme for noise reduction. Firstly, the saturation detection algorithm in signals is based on the gradient, and extreme is utilized to remove the saturation interference. On this basis, the artifact detection module based on complex network connectivity is proposed. Finally, the self-adjusting parameter integer coefficient filtering is utilized to include the baseline drift. The noise inside is filtered out. The experimental results demonstrate that the proposed method, in the case of a similar signal-to-noise ratio, has a mean square error of 15.7 and a shorter convergence time of 0.02s.