Objective: To evaluate the relationships between the variables that affect the sexual satisfaction of patients with spinal cord injuries. Design: Descriptive and cross-sectional survey. Setting: The physical medicine and rehabilitation outpatient clinic of a university hospital in Turkey. Participants: This study was performed from July to December2018. It included 103 patients with spinal cord injuries. Outcome Measures: The data were collected using an introductory information form, the American Spinal Injury Association Impairment Scale and the Golombok Rust Inventory of Sexual Satisfaction. Data were evaluated using the chi-square test, the Mann–Whitney U test, the Kruskal–Wallis test and linear regression. Results: The total mean scores on the Golombok Rust Inventory of Sexual Satisfaction were 40.2 ± 21.6 for males and 44.9 ± 18.1 for females. According to the linear regression analysis, model VII presented the best results of the relationship between physiological and psychological determinants that affect the sexual satisfaction of patients with spinal cord injuries. Model VII consisted of the variables of ASIA A and B scores, age, injury due to falling from height, being a housewife, and thinking of being unable to reach future goals. These explained 75.4% of the variation in sexual satisfaction scores. Conclusion: The participants’ mean scores on the Golombok Rust Inventory of Sexual Satisfaction were found to be affected by various variables. A significant relationship between their mean scores on the American Spinal Injury Association (ASIA) Impairment Scale and the Golombok Rust Inventory of Sexual Satisfaction was determined.