California is the primary processing tomato (Solanum lycopersicum) producer in the United States. Fusarium oxysporum f. sp. lycopercisi race 3 (Fol3), the cause of Fusarium wilt, is a major yield loss driver. Fol3 has recently been observed causing disease in resistant cultivars (I-3 R-gene), often in association with high soil salinity. This study undertook to better understand the effect of salinity on resistance-based management of Fol3. Surveys established opportunity for salinity-Fol3-tomato interactions in 44% of commercial fields examined, with harmful soil salt levels up to 3.6 dS/m (P < 0.001), high sodium (P < 0.001), and high sodicity (SAR > 13, P < 0.001). In controlled field studies of Fol3 in NaCl:CaCl2-treated soil, Fol3-resistant cultivars either only developed wilt under salt or only developed wilt above the industry non-hybrid threshold (2%) under salt across two trial years. Absence of yield differences indicate low to no economic impact of disease enhancement (P > 0.05). NaCl, CaCl2 and Na2SO4 had no effect on Fol3 propagule production in liquid agar vs. water agar controls (P > 0.05) although CaCl2 increased propagule loads 7-fold vs. ionic controls (PEG) (P = 0.036). NaCl:CaCl2 (2:1) reduced propagule loads up to 65% vs. no-salt (P = 0.029) in soil with pathogen-infested tomato tissue. These results together establish the opportunity for salinity-Fol3-tomato interactions and potential for salt to influence efficacy of resistant cultivar-based management-this does not appear to be primarily due to salt-enhancement of pathogen populations, pointing to a yet unexplored direct influence of salt on host resistance.