Bombacaceae gum (BG) is an inexpensive exudate gum containing phenolic compounds with the potential to serve as an active film base material. In this study, we found that BG (2.5%, w/v) possessed film-forming capacity with the use of glycerol (45% of BG, w/w) as a plasticizer. Owing to the inherent phenolic compounds in the BG, the film had orange-yellowish color (L = 76.35, a = 5.13, and b = 66.07), and exhibited antioxidant activity with DPPH and ABTS radical scavenging activities of 52.63% and 54.74%, respectively. Cinnamon leaf essential oil (CLE, 0.75%, 1.00%, and 1.25%) was incorporated into the BG film to confer bioactivities. The addition of CLE to the BG film caused a decrease in its tensile strength, whereas film stretching ability and water barrier properties increased. Moreover, ABTS and DPPH radical scavenging activities of the BG film containing 1.25% CLE (BC-1.25 film) increased 1.8- and 1.6-fold compared to the pure BG film, respectively. All BG films containing CLE exhibited antimicrobial activities against the tested pathogenic bacteria. In addition, the BC-1.25 film effectively inhibited lipid oxidation, indicated by retarding the generation of hydroperoxides and malondialdehyde in fresh salmon fillets during refrigerated storage. Therefore, the developed film may be used as a novel active packaging material.