Salience Of Outcomes Research Articles

Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.

Reinforcement learning (RL), particularly in primates, is often driven by symbolic outcomes. However, it is usually studied with primary reinforcers. To examine the neural mechanisms underlying learning from symbolic outcomes, we trained monkeys on a task in which they learned to choose options that led to gains of tokens and avoid choosing options that led to losses of tokens. We then recorded simultaneously from the orbitofrontal cortex (OFC), ventral striatum (VS), amygdala (AMY), and mediodorsal thalamus (MDt). We found that the OFC played a dominant role in coding token outcomes and token prediction errors. The other areas contributed complementary functions, with the VS coding appetitive outcomes and the AMY coding the salience of outcomes. The MDt coded actions and relayed information about tokens between the OFC and VS. Thus, the OFC leads the processing of symbolic RL in the ventral frontostriatal circuitry.

Human anterior insula signals salience and deviations from expectations via bursts of beta oscillations.

Functional imaging studies indicate that the insula encodes the salience of stimuli and deviations from expectations, signals that can mobilize cognitive resources and facilitate learning. However, there is no information about the physiological underpinnings of these phenomena beyond changing BOLD signals. To shed light on this question, we analyzed intracerebral local field potentials (LFPs) in five patients with epilepsy of both genders performing a virtual reality task that featured varying odds of monetary rewards and losses. Upon outcome disclosure, the anterior (but not the posterior) insula generated bursts of beta oscillations whose amplitudes were lower for neutral than positive and negative outcomes, consistent with a salience signal. Moreover, beta burst power was higher when outcomes deviated from expectations, whether the outcome was better or worse than expected, indicating that the insula provides an unsigned prediction error signal. Last, in relation to insular beta bursts, many higher-order cortical areas exhibited robust changes in LFP activity that ranged from spectrally nonspecific or differentiated increases in gamma power to bursts of beta activity that closely resembled the insular beta bursts themselves. Critically, the activity of these other cortical regions was more closely tied in time to insular bursts than task events, suggesting that they are associated with particularly significant cognitive phenomena. Overall, our findings suggest that the insula signals salience and prediction errors via amplitude modulations of beta bursts, which coincide with the near simultaneous recruitment of vast cortical territories.NEW & NOTEWORTHY Functional imaging studies indicate that the anterior insula encodes salience and deviations from expectations. Beyond changing BOLD signals, however, the physiological underpinnings of these signals are unknown. By recording local field potentials in patients with epilepsy, we found that the anterior insula generates large bursts of beta oscillations whose amplitude is modulated by the salience of outcomes and deviations from expectations. Moreover, insular beta bursts coincide with the activation of many high-order cortical areas.

Association of Maternal Cervical Disease With Human Papillomavirus Vaccination Among Offspring

Barriers to childhood vaccination against vaccine-preventable diseases, such as those due to human papillomavirus (HPV), are well known. However, the role of salience bias-the change in perception of risk due to increased familiarity with the outcome-in decisions to vaccinate children has not been explicitly studied. To assess for salience bias in parental decisions to vaccinate children. This retrospective cohort study used a time-to-event (survival) analysis to compare vaccination rates of children whose mothers had a history of cervical cancer or a cervical biopsy, who have experienced adverse vaccine-preventable outcomes, and for whom vaccination may be more salient, with a control group of children whose mothers had no such history. Participants were accrued from the MarketScan Commercial Database, including US children who turned 11 years old, when HPV vaccination is recommended, from January 1, 2014, to December 31, 2018. Data were analyzed from December 29, 2020, to September 17, 2021. Maternal history of cervical cancer or cervical biopsy. Vaccination against HPV. A total of 757 428 children (370 878 girls [49.0%] and 386 550 boys [51.0%]) were identified, of whom 38 366 had mothers with a history of cervical biopsy alone and 1084 had mothers with a history of cervical cancer. Overall, 54.2% of children (55.7% of girls and 52.7% of boys) received at least 1 vaccination by 16 years of age. In a time-to-event analysis, HPV vaccination did not differ between children whose mothers had cervical cancer vs those whose mothers did not (hazard ratio [HR] for girls, 0.99 [95% CI, 0.86-1.13]; HR for boys, 1.08 [95% CI, 0.94-1.24]). Maternal history of cervical biopsy was associated with a minimally increased hazard of vaccination (HR for girls, 1.06 [95% CI, 1.04-1.09]; HR for boys, 1.04 [95% CI, 1.01-1.06]). There were no clinically meaningful differences between groups for the tetanus/diphtheria/acellular pertussis and meningococcal vaccinations, which are also recommended at 11 years of age. In this analysis of salience bias in childhood vaccination decisions, mothers' personal history of cervical cancer or cervical biopsy was not associated with greater vaccination rates among children against HPV. These findings suggest that salience of vaccine-preventable outcomes may not have a major impact on childhood vaccine hesitancy in HPV; the role of salience should be investigated for other vaccines.

The Relationship Between Depression Symptoms and Adolescent Neural Response During Reward Anticipation and Outcome Depends on Developmental Timing: Evidence From a Longitudinal Study

BackgroundBlunted neural reward responsiveness (RR) is observed in youth depression. However, it is unclear whether symptoms of depression experienced early in development relate to adolescent RR beyond current symptoms and, further, whether such relationships with RR differ during two key components of reward processing: anticipation and outcome. MethodsWithin a prospective longitudinal study oversampled for early depression, children and caregivers completed semiannual diagnostic assessments beginning in preschool. In later adolescence, mean age = 16.49 years (SD = 0.94), youths’ (N = 100) neurophysiological responses to cues signaling likely win and loss and these outcomes were assessed. Longitudinally assessed dimensional depression and externalizing symptoms (often comorbid with depression as well as associated with RR) experienced at different developmental periods (preschool [age 3–5.11 years], school age [6–9.11 years], early adolescence [10–14.11 years], current) were used as simultaneous predictors of event-related potentials indexing anticipatory cue processing (cue-P3) and outcome processing (reward positivity/feedback negativity and feedback-P3). ResultsBlunted motivated attention to cues signaling likely win (cue-P3) was specifically predicted by early-adolescent depression symptoms. Blunted initial response to win (reward positivity) and loss (feedback negativity) outcomes was specifically predicted by preschool depression symptoms. Blunted motivational salience of win and loss outcomes (feedback-P3) was predicted by cumulative depression, not specific to any developmental stage. ConclusionsAlthough blunted anticipation and outcome RR is a common finding in depression, specific deficits related to motivated attention to cues and initial outcome processing may map onto the developmental course of these symptoms.

Time varying risk aversion

Exploiting portfolio data and repeated surveys of an Italian bank's clients, we test whether investors’ risk aversion increases following the 2008 crisis. We find that, after the crisis, both qualitative and quantitative measures of risk aversion increase substantially and that affected individuals divest more stock. We investigate four explanations: changes in wealth, expected income, perceived probabilities, and emotion-based changes of the utility function. Our data are inconsistent with the first two channels, while they suggest that fear is a potential mechanism underlying financial decisions, whether by increasing the curvature of the utility function or the salience of negative outcomes.

Corrigendum.

Corrigendum.

Mediofrontal Negativity Signals Unexpected Timing of Salient Outcomes.

The medial prefrontal cortex (mPFC) and ACC have been consistently implicated in learning predictions of future outcomes and signaling prediction errors (i.e., unexpected deviations from such predictions). A computational model of ACC/mPFC posits that these prediction errors should be modulated by outcomes occurring at unexpected times, even if the outcomes themselves are predicted. However, unexpectedness per se is not the only variable that modulates ACC/mPFC activity, as studies reported its sensitivity to the salience of outcomes. In this study, mediofrontal negativity, a component of the event-related brain potential generated in ACC/mPFC and coding for prediction errors, was measured in 48 participants performing a Pavlovian aversive conditioning task, during which aversive (thus salient) and neutral outcomes were unexpectedly shifted (i.e., anticipated or delayed) in time. Mediofrontal ERP signals of prediction error were observed for outcomes occurring at unexpected times but were specific for salient (shock-associated), as compared with neutral, outcomes. These findings have important implications for the theoretical accounts of ACC/mPFC and suggest a critical role of timing and salience information in prediction error signaling.

Implicit emotion regulation affects outcome evaluation.

Efficient implicit emotion regulation processes, which run without awareness, are important for human well-being. In this study, to investigate the influence of implicit emotion regulation on psychological and electrophysiological responses to gains and losses, participants were required to select between two Chinese four-character idioms to match the meaning of the third one before they performed a monetary gambling task. According to whether their meanings were related to emotion regulation, the idioms fell into two categories. Event-related potentials and self-rating emotional experiences to outcome feedback were recorded during the task. Priming emotion regulation reduced subjective emotional experience to both gains and losses and the amplitudes of the feedback-related negativity, while the P3 component was not influenced. According to these results, we suggest that the application of implicit emotion regulation effectively modulated the subjective emotional experience and the motivational salience of current outcomes without the cost of cognitive resources. This study implicates the potential significance of implicit emotion regulation in decision-making processes.

How to Beat Procrastination

Procrastination, defined as the subjectively aversive inability to initiate or complete the pursuit of a given goal, is a common phenomenon in academic contexts. This theoretical paper presents a dynamic model that centers on the role of goal focus in influencing procrastination during goal pursuit. Our central hypothesis is that focusing on the means of goal pursuit (i.e., adopting a process focus) reduces procrastination, particularly when fear of failure is high. Focusing on the means should decrease the salience of performance outcomes and thereby reduce fear of failure. This, in turn, should facilitate the initiation and maintenance of goal pursuit. In contrast, when means are perceived as unpleasant (high task aversiveness), focusing more on the outcome of goal pursuit (i.e., adopting an outcome focus) should reduce procrastination by directing attention away from the means while highlighting the importance of goal achievement. Furthermore, the model takes account of dynamic contextual factors, particularly the distance to a given deadline.

How does cognitive reappraisal affect the response to gains and losses?

To investigate the influence of cognitive reappraisal, one important kind of emotion regulation strategy, on psychological and electrophysiological responses to gains and losses, a monetary gambling task was performed in two conditions, that is, spontaneity and regulation. Event-related potentials (ERP) and self-rating emotional experiences to outcome feedback were recorded during the task. Cognitive reappraisal reduced self-rating emotional experience to both gains and losses and the amplitudes of the feedback-related negativity (FRN) and the P3 of ERPs. According to these results, we suggest that the application of cognitive reappraisal strategy significantly modulated the motivational salience of current outcomes, thus weakening the subjective emotional experience elicited. In addition, cognitive reappraisal might have changed the allocation of cognitive resources during outcome evaluation. This study extends emotion regulation studies by applying monetary outcomes as emotional stimuli, and also implicates the significance of emotion regulation in decision-making processes.

The benefits of discussing suicide with Alaska native college students: Qualitative analysis of in-depth interviews.

Suicide represents a significant health disparity for communities in rural Alaska, and has implications for mental health among people who have lost loved ones from suicide. A qualitative interview study was conducted to examine the ways in which suicide has affected the lives of college students who have migrated from rural villages to an urban university (N = 25). The present research represents a secondary aim of the study-specifically, we examined the affective responses of Alaska Native college students from rural villages after completing in-depth semistructured interviews about their experiences related to suicide. Debriefing questions posed at the conclusion of the interviews revealed that the majority of participants (n 16) stated they felt "better" after completing the interview, and no participants reported feeling "worse." No participant required the use of the safety plan developed in case of severe emotional distress. All participants indicated they would be interested in participating in future research. Analysis of questions pertaining to the interview experience revealed the salience of foundation (the participant's prior experience discussing issues like suicide), process (the interview questions and questioning style), and outcomes (the challenges and benefits of participation described by the respondent). Findings provided important insights concerning the experience of discussing past trauma, perceived importance of research addressing coping with suicide, and the influence of past experiences in the process of talking about suicide.

Outcomes of Absence Control Initiatives

Although considerable research has examined various antecedents of employee absence, relatively little research has examined the effects of organizational absence control initiatives on different types of absence, or how differences in employee perceptions of these initiatives may influence employee absences. Through the lens of organizational justice, the authors address this gap in the literature by tracking absenteeism in two manufacturing plants that implemented, at different times, absence control initiatives designed to increase the salience of absence outcomes via explicit rewards and punishments. Results showed that the policy changes had the intended effect of reducing casual absence, but also the unintended effect of increasing Family and Medical Leave Act (FMLA) absence. The results for disability-based absence were mixed. Individual employee perceptions of both the salience of absence outcomes and the fairness of the absence policies showed differential effects on casual and FMLA absence. These perceptions interacted such that employees who perceived the policies to be more salient and unfair had the highest instances of FMLA absence. Implications for absence and justice research and practice are discussed.

Social Distance, Framing, and Judgment: A Construal Level Perspective

Drawing upon construal level theory, this research investigates the influence of social distance on individuals’ responses to persuasive messages. Experiment 1 (N = 133) demonstrates that the persuasive impact of a gain frame becomes stronger when people make judgments for socially distant (e.g., others) versus proximal entities (e.g., selves). On the other hand, the persuasive impact of a loss frame remains the same across different levels of social distance. Experiment 2 (N = 135) shows that the persuasiveness of a societal frame becomes stronger when people make judgments for socially distant versus proximal entities, whereas the persuasiveness of an individual frame is unaffected by social distance. Experiment 3 (N = 80) provides evidence that mental salience of positive and societal outcomes of an action increases as social distance increases, whereas mental salience of negative and individual outcomes remains the same across different levels of social distance.

Sex-role norms and gender-related attainment values: Their role in attributions of success and failure

Sex-role norms and gender-related attainment values are considered as possible mediators of gender differences in causal attributions for success and failure. Several revisions of attribution theory are suggested in order to extend the theory to include corollaries concerning sex-role norms. The concept of sex-role consistency is employed as a basis for understanding how sex-role norms affect causal attributions. In addition, gender-related attainment values are hypothesized to affect causal attributions via differential salience and functioning of outcomes. Finally, the analysis is applied to an additional area of achievement-related behavior, gender differences in reward allocation norm choice.

The nature of importance perceptions: A test of a cognitive model

This study empirically examines an alternative conceptual approach to the nature of importance perceptions. Current interpretations of importance evaluations—demand, need, and value-based approaches—have been primarily connotative and continue to remain bereft of convincing logical or empirical support. Borrowing from social — psychological theories of cognitive structure, the study tests the usefulness of a conceptualization of importance perceptions which presents the construct as a function of cognitive centrality, dependence, criticalness, and temporary salience of factors and outcomes in the individual cognitive space. The model is examined over a wide range of factors with findings indicating that significant proportions of variance in importance rating/rankings may be thus explained. Implications for management theory and practices are discussed.