Abstract In order to fulfil its mission, the Belgian Regulatory Body (constituted in Belgium by FANC and Bel V) has set up its own Research & Development programme, independent from the Waste Management Organisation's one. The Regulatory Body's Research & Development programme is mostly intended to investigate safety issues with the objective to be able to assess if the safety concept developed by the Waste Management Organisation fulfils the defined safety requirements. It includes the development and the follow-up of in situ experiments in underground research laboratories (e.g. in the Mont Terri project in Switzerland and at Tournemire in France). Such activities are essential to maintain and improve the scientific and technical skills, to strengthen the independence from the Waste Management Organisation and to build public confidence in the regulatory function. More generally, Research & Development in underground research laboratories is important to the Regulatory Body as it allows investigating processes, technologies and activities important to safety under in situ conditions. In particular, it is essential to accurately identify and characterize the processes upon which the safety functions of a disposal system rely, as well as processes that may affect the system performance. It is also necessary to demonstrate that construction and operational methods and technologies are technically feasible and can be implemented as assumed in the safety case. Such research and development activities are of great importance to properly manage some of the key uncertainties associated with a disposal programme and in particular to identify, characterize and reduce them where needed.