Objectives: Assess the quality of life among children with Thalassemia and determine the association between quality of life of Thalassemia children with selected demographic factors. Materials and Methods: The present study was aimed at assessing quality of life among thalassemia children using descriptive survey approach. A total of 100 Thalassemia children were selected by purposive sampling technique, from Safdarjung Hospital and Kalawati Saran Children Hospital OPD and Day Care Center. Structured interview schedule was used to assess quality of life among Thalassemia children. Analysis and interpretation of data for the present study were based on data collected through structured interview schedule from 100 children with Thalassemia by using both descriptive and inferential statistics based on objectives of the study. Result: The data was collected, analyzed and interpreted in terms of the objectives. Descriptive and inferential statistics were utilized for the analysis of the data. The level of significance set for testing the association was 0.05 using chi-square test. The mean, median and standard deviation values were close to each other which indicate that group was homogenous. Mean=86.58, Median=87.5 and standard deviation of quality of life score was 10.95. Conclusion: The major findings of the study were, majority of children were having moderate quality of life and there was a significant association between quality of life of Thalassemia children and selected demographic variables. How to cite this article: Bains M, Mandal K. A Study to Assess the Quality of Life among Children with Thalassemia and its Relationship with Selected Factors in Selected Hospitals of Delhi. Ind J Youth Adol Health 2019; 6(3): 1-7. DOI: https://doi.org/10.24321/2349.2880.201911