This study aims to examine challenges teachers often face when teaching Grade 12 Business Studies in schools situated at the rural Umbumbulu circuit of Umlazi district, in the province of KwaZulu-Natal, South Africa. A qualitative research methodology was used to explore challenges that teachers encountered when teaching Grade 12 Business Studies. A purposive sample of five Grade 12 teachers was selected from five rural secondary schools that offered Business Studies as a curriculum subject in the Umbumbulu circuit. The need to elicit lived experiences of a few Grade 12 Business Studies teachers in rural schools in ways that could relate to challenges encountered by teachers inspired the choice of case study research design. Face-to-face, semi-structured interviews were used to generate data that was analysed through thematic analysis as a method of analysing qualitative data. The study found that in teaching Grade 12 Business Studies in rural schools, teachers had to face a number of challenges such as the unavailability of updated textbook publications, the language of learning and teaching and learner absenteeism, and late arrival at school. The study raises awareness of challenges Grade 12 Business Studies teachers in rural schools may face in teaching the subject so that teachers in emerging economies can think of ways to strengthen their resilience against these challenges and maximize their teaching potential.