Industrial revitalization is the premise, foundation and key to achieving the rural revitalization strategy. Industrial revitalization is the primary task and central issue of the rural revitalization strategy. The Chinese medicinal materials industry covers the primary, secondary and tertiary industries, with a long industrial chain, high added value and strong driving force, and plays an important role in promoting rural economic and social development. Bozhou City is rich in Chinese medicinal resources, has a good foundation for the Chinese medicinal materials industry and distinctive characteristics. It is a dominant and characteristic industry and a people-enriching industry in Bozhou City and even Anhui Province. This paper investigates the development status of the rural Chinese medicinal materials industry in three counties and one district in Bozhou City, analyzes the advantages, disadvantages, opportunities and challenges of the Chinese medicinal materials industry in Bozhou City in promoting rural industrial revitalization. On this basis, a systematic and specific implementation path and guarantee system for the Chinese medicinal materials industry in Bozhou City to help rural industrial revitalization are designed, including top-level design, improving infrastructure construction, cultivating modern business organizations, integrating the development of Chinese medicinal materials industry, and strengthening the construction of various industrial chains of rural Chinese medicinal materials production, processing, warehousing and logistics, and brand marketing, etc., and building a guarantee system in four aspects: organizational coordination, financial support, talent training, and scientific and technological support.