Particle gradations significantly affects the dynamic response of water-saturated soft coal. To obtain the dynamic response of soft coal to various particle gradations, static and dynamic mechanical properties of water-saturated soft coal with different particle gradations were tested and compared. During these processes, the enhancement coefficient of the dynamic mechanical parameters to the corresponding static mechanical parameters was set as an index to describe the effect of non-uniformity coefficient Cu and median diameter d50. The results demonstrate that both the static and dynamic mechanical parameters of the water-saturated soft coal were affected by particle gradations. The enhancement coefficient was affected by both the d50 and Cu, which was microscopically attributed to effect of the d50 and Cu on the average dynamic liquid bridge force and scale dynamic rupture energy among the particles based on the microstructure and dynamic fracture evolution processes. In addition, the dimensionless scale rupture energy model among the water-bearing particles varied with the d50 and Cu were further established and applied to discuss the effect mechanism of particle gradations on the dynamic response of water-saturated soft coal. On this basis, the support measures of roadways in coal seam with different particle gradations were further discussed.