As the runoff series exhibit nonlinear and nonstationary characteristics, capturing the embedded periodicity and regularity in the runoff series using a single model is challenging. To account for these runoff characteristics and enhance the forecasting precision, this research proposed a new empirical wavelet transform–particle swarm optimization–support vector machine (EWT–PSO–SVM) hybrid model based on “decomposition-forecasting-reconstruction” for runoff forecasting and investigated its effectiveness in the karst area. First, empirical wavelet transform (EWT) was employed to decompose the original runoff series into multiple subseries. Second, the support vector machine (SVM) optimized by particle swarm optimization (PSO) was applied to forecast every signal subseries. Finally, this study summarized the predictions of the subseries to reconstruct the ultimate runoff forecasting. The developed forecasting model was assessed by applying the monthly runoff series of the Chengbi River Karst Basin, and the composite rating index combined with five metrics was adopted as the performance evaluation tool. From the results of this research, it is clear that the EWT–PSO–SVM model outperforms both the PSO–SVM model and the SVM model in terms of the composite rating index, reaching 0.68. Furthermore, verifying the performance stability, the developed model was also compared with PSO–SVM and SVM models under different input data structures. The comparison demonstrated that the hybrid EWT–PSO–SVM model had a robust performance superiority and was an effective model that can be applied to karst area runoff forecasting.