<span>Otitis is a disease that occurs in the middle ear in the form of inflammation. This research aims to develop an analysis model for the classification of Otitis disease based on knowledge patterns based on symptoms and type of disease. The analysis methods used include the performance of the certainty factor (CF), rough set (RS), artificial neural network (ANN), and decision tree (DT) methods. CF and RS performance can be used to generate classification rule patterns. These rule patterns become new knowledge in the classification analysis process using the concept of deep learning (DL). DL analysis with ANN and DT performance can work optimally in exploring and discovering hidden knowledge. Based on the results of performance testing, the combination of CF and RS in preprocessing can present a classification pattern of 106 rules. The output of DL analysis results is proven to produce precise and accurate classification results with an accuracy of 89%. Based on these results, the analytical model developed was proven to be effective in classifying Otitis disease. Not only that, this research is also able to contribute to updating the knowledge-based system in the classification process.</span>