The Savonius hydrokinetic turbine (HKT) is both cost-effective and reliable, providing clean energy with minimum environmental impact. The efficiency of the Savonius rotor can be improved by modifying the blade profile to increase the effective torque. However, past research works reported that modifying the blade profile is quite challenging due to small Cp improvement and design constraint. Therefore, the present study proposes a newly developed blade profile blueprint, akin to parameterizable designs such as the modified Bach and Benesh profiles but offering more shape versatility. This new blueprint is optimized with a systematic design of experiment (DOE) using a 3D computational fluid dynamics (CFD) simulation to maximize the Cp. The best design is determined statistically using the Taguchi method and analysis of variance (ANOVA). The optimized rotor profile enhances Cp by approximately 10.9 % compared to the conventional Savonius rotor at the optimal TSR (best Cp = 0.159) and 16.7 % improvement at a higher TSR value of 0.9 (Cp = 0.158). Moreover, the optimized rotor outperforms the Fibonacci rotor (Fibonacci blade profile) by 27 % in terms of efficiency. A thorough CFD analysis suggests that the optimized blade profile has a greater lift generated at the convex side of the advancing blade due to its streamlined shape, which delays the flow separation further up to the root of the blade. The confirmation test (experiment) is also performed to verify the Cp improvement of the optimized rotor, and the results herein concluded that the present CFD prediction is accurate and consistent with the experimental values.