Rotational x-ray therapy permits the delivery of a large tissue dose of radiation to a deep-seated tumor, with relatively small doses to adjacent structures and to the skin. This method of treatment may be considered an extreme utilization of the technic of cross-firing, since by rotation of the patient relative to the x-ray beam there are an infinite number of portals of entry. Since Pohl (5) first suggested rotational therapy in 1906, many radiologists have recognized its advantages. In recent years de Rochemont (6), J. Nielsen (4), Hawley (3), Hare and Trump (2), and Greene (1) have applied the basic method, usually with a particular refinement in equipment or technic. This report sets forth some experiences in the use of a standard deep-therapy machine in conjunction with a unit which rotates the patient in his vertical axis. Rotational therapy with x-rays of any quality has been shown to have advantages over the use of multiple fixed ports in the treatment of deep-seated lesions. The ratio of tumor dose to skin dose becomes increasingly favorable as the half-value layer increases. Futhermore, radiations of higher energies provide a more homogeneous dosage distribution in any plane perpendicular to the central ray. This can be seen by examination of isodose curves; at higher energies, the curves are flatter. It is, however, practicable to employ x-rays generated at 200–250 kv. The half-value layer of the beam utilized in the work to be reported is 1.5 mm. of copper. Selection of Target-to-Axis-of-Rotation Distance: For any quality of radiation, the target-axis distance will have to be short enough to give a reasonable dosage rate, but as long as possible for better depth dose distribution. Most of the European work appears to have been done with x-rays generated at 180–200 kv., half-value layer 1.0 mm. of copper, and target-axis distance 50 cm. Although improvement is slight with increased distance, a target-axis distance of 85 cm., which is practicable with the 250-kv. equipment, does afford better depth dose distribution. Since the cross section of the human body is not circular, the target-skin distance varies constantly, but with a target-axis distance of 85 cm. the target-skin distance is seldom less than 65 cm. Applicability of Conventional Isodose Charts to Determination of Dose in Rotation Therapy with Radiation of Half-Value Layer 1.5 mm. Copper: Figure 1 shows a centrally located tumor 10 cm. in diameter, lying in the isodose chart for a 10 × 15 cm. field at 70 cm. target-skin distance, half-value layer 1.5 mm. copper. As the body turns on an axis at A, the tumor will always be completely within a region defined by WXYZ, which can be called the “effective beam.” All other parts of the body are sometimes in this beam and sometimes outside it. It is not, however, self-evident that doses throughout the tumor are uniform. Part of the mass is always at the center of the beam, and parts are near the edge.