Time-dependent and incompressible squeezing flow of Casson and micropolar nanofluids is analyzed. The non-Newtonian liquids are confined through parallel disks. The bottom disk is saturated in the plane z = 0 and the fluid is squeezed by the movement of the upper disk along axial direction. Nanofluid theory (Buongiorno model) is accomplished in the flow phenomenon. A uniform injection/suction is act upon at the lower disk. Velocity, thermal and concentration slip effects are also incorporated at the bottom fixed disk. The similarity functions are first accomplished in order to achieve the governing system of ordinary differential equations and then the system is solved in numerical manner using Runge-Kutta-Fehlberg fourth fifth (RKF-45) order numerical procedure. Results are disclosed in tabular and graphical forms against the various physical quantities. For the validation of our numerical technique, the results are compared well with the literature work under limiting case. It is perceived that increased squeezing Reynolds number pushed the radial velocity profiles towards the upper disk. The micropolar parameter tends to the fluid rotation in opposite way due to which microrotational field first enhanced and then reduced by the vortex viscosity parameter.