The automotive industry is currently transforming, primarily due to the rise of electric and hybrid vehicle technologies and the need to reduce vehicle mass and energy losses to decrease consumption, pollution, and raw material usage. Additionally, road surface manufacturers emphasize improving pavement durability and reducing rolling noise. This necessitates precise load condition definitions and drives the need for reliable wheel testing benches. Many current benches use abrasive-coated rollers or synthetic tapes, but devices capable of testing on actual road surfaces are rare. In this work, a novel device for testing tire-pavement interaction is proposed. The system features a cart moving along a closed-track platform, ensuring test repeatability and enabling structural durability tests on uneven surfaces with installed obstacles. The cart is equipped with a cantilever arm capable of supporting either a testing wheel with customizable dimensions and kinematic parameters or a tire integrated with a complete suspension system, moving along a customizable pavement surface. The system includes actuators and sensors for applying vertical loads and adjusting the alignment of the testing wheel (slip angle, camber angle, etc.), allowing the characterization of tire behavior such as wear, fatigue, rolling noise, and rolling resistance. Multibody simulations were performed to evaluate the bench’s feasibility in terms of kinematics, power requirements, and structural loads. Results confirmed how this novel test bench represents a promising advancement in tire testing capabilities, enabling comprehensive studies on tire performance, noise reduction, and the structural dynamics of vehicle subsystems.