Role Of Fear Research Articles

MORALIZING METAPHORS: THE ROLE OF FEAR IN THE GOLEM OF GUSTAV MEYRINK AND FRANKENSTEIN BY MARY SHELLEY

This article explores the nature of fear as it is represented in the novels Frankenstein and The Golem, first establishing this emotion as possessor of a deliberate moral undertone that serves a specific purpose for each text. This problematic is addressed from the perspective of genre theory, specifically talking about the role of fear in the configuration of fantastic literature and of how in these novels those norms are put into effect.

El temor como mecanismo de control político para dirigir la voluntad del pueblo en El Salvador, una mirada desde la teoría política de El Príncipe de Maquiavelo

Fear, like a control mechanism for controlling the will of the people, is an application of the political theory of Machiavelli, The Prince, to understand the reality of El Salvador. The role of fear in the application of government politics for the Salvadoran society, of the 80s, was decisive to govern based in the control the will of the people and the influence of a passion. The level of importance was decisive, especially when it was carried out as a result of the civil war that takes place, in which a big group of the civil population fights. Rape of women and murder of male, boss of home, were configured as two mechanisms used by Salvadoran State entities for the implementation of fear in 80s in El Salvador.

Modulation of Fear and Arousal Behavior by Serotonin Transporter (5-HTT) Genotypes in Newly Hatched Chickens.

The serotonin transporter (5-HTT) plays a key role in regulating serotonergic transmission via removal of serotonin (5-hydroxytryptamine, 5-HT) from synaptic clefts. Alterations in 5-HTT expression and 5-HT transmission have been shown to cause changes to adult behavior including fear. The objective of the present study was to investigate the 5-HTT role in fear in birds at the very early stages of post-hatching life. Using an avoidance test with an elevated balance beam, which was based on depth perception and the respective fear of heights, we assessed fear-related avoidance behaviors of newly hatched chicks of the three functional 5-HTT genotypes W/W, W/D and D/D. Newly hatched chicks of the genotype D/D, which was linked to high 5-HTT expression, showed less intensive avoidance responses as measured by decreased latency to jump than W/W and W/D chicks. Further, significantly fewer D/D hens than W/W hens showed fear-like behavior that resembled a freezing response. Furthermore, in an arousal test the arousal reaction of the chicks in response to an acute short-term visual social deprivation in the home compartment was assessed 5 weeks after hatching, which also revealed that D/D chicks exhibited decreased arousal reaction, compared to W/W chicks. Thus, the results indicate that fear responses differ in D/D chicks in the early post-hatching periods, possibly due to the different expression of 5-HTT respectively 5-HT levels in this strain.

Smaller volumes in the lateral and basal nuclei of the amygdala in patients with panic disorder.

The amygdala plays an important functional role in fear and anxiety. Abnormalities in the amygdala are believed to be involved in the neurobiological basis of panic disorder (PD). Previous structural neuroimaging studies have found global volumetric and morphological abnormalities in the amygdala in patients with PD. Very few studies, however, have explored for structural abnormalities in various amygdala sub-regions, which consist of various sub-nuclei, each with different functions. This study aimed to evaluate for volumetric abnormalities in the amygdala sub-nuclei, in order to provide a better understanding neurobiological basis of PD. Thirty-eight patients with PD and 38 matched healthy control (HC) participants underwent structural MRI scanning. The volume of the whole amygdala, as well as its consistent sub-nuclei, were calculated using FreeSurfer software. Relative volumes of these amygdala sub-regions were compared between the two groups. Results showed significantly smaller volumes in the right lateral and basal nuclei in the patients with PD compared with the HC. Lateral and basal nuclei are thought to play crucial role for processing sensory information related with anxiety and fear. Our results suggest that these particular amygdala sub-regions play a role in the development of PD symptoms.

The Role of Fear and Impulsivity in Exogenous Attention to Emotional Stimuli as Indexed by the Early Posterior Negativity and Late Positive Potential

The Role of Fear and Impulsivity in Exogenous Attention to Emotional Stimuli as Indexed by the Early Posterior Negativity and Late Positive Potential

Explicit and Implicit Components of the Emotional Processing in Non-organic Vision Loss: Behavioral Evidence About the Role of Fear in Functional Blindness.

Non-organic vision loss (NOVL), a functional partial or global vision loss, might be considered a manifestation of conversion disorder. The few previous studies focused on investigating the relationship between cerebral activity and subjective symptoms in NOVL; however, the emotional processing is still neglected. In the present case-controls study, we investigated the capability of two individuals diagnosed with NOVL to recognize implicitly the emotions of fear and anger; this was assessed through a facial emotion recognition task based on the redundant target effect. In addition, the level of alexithymia was measured by asking them to judge explicitly their ability to identify and describe emotions. Both individuals showed selective difficulties in recognizing the emotion of fear when their performance was contrasted with a matched control sample; they also mislabeled other emotional stimuli, judging them as fearful, when they were not. However, they did not report alexithymia when measured using a standard questionnaire. This preliminary investigation reports a mismatch between the implicit (i.e., the behavior in the experimental paradigm) and the explicit (i.e., the subjective evaluation of one’s own emotional capability) components of the emotional processing in NOVL. Moreover, fear seems to represent a critical emotion in this condition, as has been reported in other psychiatric disorders. However, possible difficulties in the emotional processing of fear would emerge only when they are inferred from an implicit behavior, instead of a subjective evaluation of one’s own emotional processing capability.

Short-term and Long-term Effects of Fear Appeals in Improving Compliance with Password Guidelines

Passwords are the most widely used method of authentication on the Internet, but users find compliance with password guidelines difficult, and we know little about the long-term effects of attempts to improve compliance. In this paper, we extend the work of fear appeals use in the IS security domain to investigate their longer-term effects. We conducted a longitudinal experimental study to examine fear appeals’ long- and short-term effects. Using a model based on protection motivation theory (Rogers, 1983), we found that fear of threat, perceived password effectiveness, and password self-efficacy predicted compliance. We also found that neither perceived vulnerability to a security attack nor perceived severity of an attack influenced compliance. Providing persuasive communication improved compliance with password guidelines and resulted in significantly stronger passwords, but the effects on compliance intentions were only short term. This study extends our understanding of the factors that influence compliance with password guidelines and how we can modify them to improve compliance. We raise interesting questions about the role of fear in different IS security contexts. We also highlight the need for more research on the long-term impact of persuasive communication.

FROM PROXIMITY SEEKING TO RELATIONSHIP SEEKING: WORKING TOWARDS SEPARATION FROM THE “SCAREGIVERS”

Traditionally psychoanalysis showed interest in the child’s ambivalent relationship towards the object. Psychoanalysis also did not put great emphasis on the role of fear in a child’s life, in particular fear that has been inflicted by the caregivers (Slade, 2013). It was Mary Main who placed fear in the face of attachment needs and named it as disorganized attachment style. The research findings have given us a new lens into the way we see human behavior as displayed in many of our traumatized clients. The child’s need for both protection and autonomy are universal and has been at the heart of object relations and attachment theories. It is there where matters of core-relatedness and a developed sense of self are most involved. This paper discusses a client who suffered extensive sexual abuse. Her attachment to her mother, who I called her “scaregiver,” was preoccupied, enmeshed and coercive as well as being disorganized. The lack of boundaries and the controlling relationship the client had with her mother was re-enacted in the therapeutic dyad. This paper explores these dynamics and how attachment-based psychotherapy enabled a move towards safety for the client followed by better functioning, and more so enabled her to move towards intersubjectivity, a deeper understanding of her lack of boundaries, separateness and need for autonomy.

Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.

The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components of amygdalar circuits, which control appropriate fear responses. Despite this, the molecular processes guiding ITC development remain poorly understood. Here we establish the zinc finger transcription factor Tshz1 as a marker of ITCs during their migration from the dorsal lateral ganglionic eminence through maturity. Using germline and conditional knock-out (cKO) mouse models, we show that Tshz1 is required for the proper migration and differentiation of ITCs. In the absence of Tshz1, migrating ITC precursors fail to settle in their stereotypical locations encapsulating the lateral amygdala and BLA. Furthermore, they display reductions in the ITC marker Foxp2 and ectopic persistence of the dorsal lateral ganglionic eminence marker Sp8. Tshz1 mutant ITCs show increased cell death at postnatal time points, leading to a dramatic reduction by 3 weeks of age. In line with this, Foxp2-null mutants also show a loss of ITCs at postnatal time points, suggesting that Foxp2 may function downstream of Tshz1 in the maintenance of ITCs. Behavioral analysis of male Tshz1 cKOs revealed defects in fear extinction as well as an increase in floating during the forced swim test, indicative of a depression-like phenotype. Moreover, Tshz1 cKOs display significantly impaired social interaction (i.e., increased passivity) regardless of partner genetics. Together, these results suggest that Tshz1 plays a critical role in the development of ITCs and that fear, depression-like and social behavioral deficits arise in their absence.SIGNIFICANCE STATEMENT We show here that the zinc finger transcription factor Tshz1 is expressed during development of the intercalated cells (ITCs) within the mouse amygdala. These neurons have previously been shown to play a crucial role in fear extinction. Tshz1 mouse mutants exhibit severely reduced numbers of ITCs as a result of abnormal migration, differentiation, and survival of these neurons. Furthermore, the loss of ITCs in mouse Tshz1 mutants correlates well with defects in fear extinction as well as the appearance of depression-like and abnormal social interaction behaviors reminiscent of depressive disorders observed in human patients with distal 18q deletions, including the Tshz1 locus.

Focus group study to identify the central facets of fear of hypoglycaemia in people with Type 2 diabetes mellitus.

To determine key worries about hypoglycaemia among insulin-using adults with Type 2 diabetes using a focus group approach. Thirteen focus groups were conducted in three diabetes outpatient care units and one peer support group was set up, in Germany. A total of 64 insulin-dependent adults with Type 2 diabetes (36.5% women, mean age 65.2 ± 11.0 years) discussed their worries about hypoglycaemia. The qualitative results were assigned into thematic categories using a bottom-up coding procedure. Participants completed the Hypoglycaemia Fear Survey and demographic measures were recorded. The results of the Hypoglycaemia Fear Survey were contrasted with the focus group findings to evaluate how accurately the Hypoglycaemia Fear Survey comprehensively captures features of fear of hypoglycaemia in Type 2 diabetes. Eight themes were identified: 'unconsciousness/death'; 'aloneness/ helplessness', 'fear of hurting somebody'; 'shame'; 'loss of physical control'; 'long-term complications'; 'diabetes self-management issues'; and 'impaired awareness'. A total of 30 participants (46.9%) scored ≥3 on at least one item of the Hypoglycaemia Fear Survey worry subscale, indicating elevated worries. The Hypoglycaemia Fear Survey comprehensively captured all identified themes. Self-efficacy with regard to diabetes self-management seemed to play an important role in fear of hypoglycaemia in Type 2 diabetes. Given that even subclinical worries can have negative effects on quality of life and diabetes self-management, emphasis should be placed on diabetes education; in particular, to help patients to develop self-efficacy concerning diabetes self-management. The Hypoglycaemia Fear Survey comprehensively captures hypoglycaemia worries in Type 2 diabetes. Additional assessment of self-efficacy might be beneficial to identify people at risk of developing hypoglycaemia worries.

Synapse-specific astrocyte gating of amygdala-related behavior.

The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A2A receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.

The Effects of the Vividness of Cigarette Package Warnings on Smokers’ Intention to Quit Smoking: The Mediating Roles of Fear, Disgust, and Cognitive Responses

The Effects of the Vividness of Cigarette Package Warnings on Smokers’ Intention to Quit Smoking: The Mediating Roles of Fear, Disgust, and Cognitive Responses

Calcium signalling in medial intercalated cell dendrites and spines.

Dendritic and spine calcium imaging in combination with electrophysiology in acute slices revealed that in medial intercalated cells of the amygdala: Action potentials back-propagate into the dendritic tree, but due to the presence of voltage-dependent potassium channels, probably Kv4.2 channels, attenuate over distance. A mixed population of AMPA receptors with rectifying and linear I-V relations are present at individual spines of a single neuron. Decay kinetics and pharmacology suggest tri-heteromeric NMDA receptors at basolateral-intercalated cell synapses. NMDA receptors are the main contributors to spine calcium entry in response to synaptic stimulation. Calcium signals in response to low- and high-frequency stimulation, and in combination with spontaneous action potentials are locally restricted to the vicinity of active spines. Together, these data show that calcium signalling in these GABAergic neurons is tightly controlled and acts as a local signal. The amygdala plays a central role in fear conditioning and extinction. The medial intercalated (mITC) neurons are GABAergic cell clusters interspaced between the basolateral (BLA) and central amygdala (CeA). These neurons are thought to play a key role in fear and extinction, controlling the output of the CeA by feed-forward inhibition. BLA to mITC cell inputs are thought to undergo synaptic plasticity, a mechanism underlying learning, which is mediated by NMDA receptor-dependent mechanisms that require changes in cytosolic calcium. Here, we studied the electrical and calcium signalling properties of mITC neurons in GAD67-eGFP mice using whole-cell patch clamp recordings and two-photon calcium imaging. We show that action potentials back-propagate (bAP) into dendrites, and evoke calcium transients in both the shaft and the dendritic spine. However, bAP-mediated calcium rises in the dendrites attenuate with distance due to shunting by voltage-gated potassium channels. Glutamatergic inputs make dual component synapses on spines. At these synapses, postsynaptic AMPA receptors can have linear or rectifying I-V relationships, indicating that some synapses express GluA2-lacking AMPA receptors. Synaptic NMDA receptors had intermediate decay kinetics, and were only partly blocked by GuN2B selective blockers, indicating these receptors are GluN1/GluN2A/GluN2B trimers. Low- or high-frequency synaptic stimulation raised spine calcium, mediated by calcium influx via NMDA receptors, was locally restricted and did not invade neighbouring spines. Our results show that in mITC neurons, postsynaptic calcium is tightly controlled, and acts as a local signal.

Behavioural testing based breeding policy reduces the prevalence of fear and aggression related behaviour in Rottweilers

Behavioural testing allows to exclude dogs that are fearful and aggressive from the breeding population, but relatively little is known about the effectiveness of such strategies in practice. From 2001 till 2009 parent purebred Dutch Rottweilers had to pass the Socially Acceptable Behaviour (SAB)-test for their offspring to obtain a pedigree certificate. We evaluated if this breeding policy of excluding fearful and aggressive Rottweilers, as diagnosed by the SAB-test, indeed reduced the prevalence of fear and aggression in the Dutch Rottweiler population. Owner-reported assessments of their dogs’ behaviour were compared between groups of Rottweilers with or without pedigree certificates, assuming the Rottweiler look-a-likes to represent the control condition of no breeding policy regarding fear and aggression. A total of 822 Rottweiler owners filled out the Canine Behavioural Assessment and Research Questionnaire (C-BARQ) on problem behaviour, including 7 behavioural categories related to fear and aggression. Problem behaviour prevalence and explanatory factors were investigated by multivariable logistic regression.The prevalence of Stranger-directed fear (P<0.05) and Non-social fear (P<0.01) was lower in the group of pedigrees than in the group of look-a-likes, with a same tendency for Stranger-directed aggression (P=0.056). Analysing the combined C-BARQ scores for the behaviour categories that are assessed with the SAB-test, namely Stranger-directed aggression, Dog-directed fear/aggression, Stranger-directed fear and Non-social fear, revealed that one sixth of the pedigree Rottweilers showed these behaviours compared to one third of the look-a-likes (P<0.0001). Strong associations were found between Stranger-directed aggression and Dog-directed fear/aggression (P<0.001) or Social Fear (P<0.001), indicating the role of fear in aggression towards unfamiliars. The association between Stranger-directed aggression and chase proneness (P<0.01) seems to illustrate how different motivations may underlie a same manifestation of aggression. Familiar dog aggression associated with Owner-directed aggression (P<0.001), implicating that such aggressions may have do with conflicts over status. Found associations between types of fear/aggression will have in part reflected shared underlying causes, and reflect the known comorbidity of problem behaviours. Their associations with dog and/or owner characteristics indicated several possible risk factors for fear/aggression. However, associations with common risk factors like sex and reproductive status were not found.Taking into account behaviour test outcomes in Rottweiler pedigree certification was associated with a reduced prevalence of fear and aggression. The exclusion of fear/aggressive individuals from the breeding population on the basis of SAB-test outcomes may have had favourable effects on population genetics or incited preventive actions by breeders like not putting a dog forward for pedigree certification. In our view, validated behaviour tests like the SAB-test can help to reduce unwanted behaviours in dog populations by breeding policies.

The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning.

Studies show that neuropeptide-receptor systems in the basolateral amygdala (BLA) play an important role in the pathology of anxiety and other mood disorders. Since GPR171, a recently deorphanized receptor for the abundant neuropeptide BigLEN, is expressed in the BLA, we investigated its role in fear and anxiety-like behaviors. To carry out these studies we identified small molecule ligands using a homology model of GPR171 to virtually screen a library of compounds. One of the hits, MS0021570_1, was identified as a GPR171 antagonist based on its ability to block (i) BigLEN-mediated activation of GPR171 in heterologous cells, (ii) BigLEN-mediated hyperpolarization of BLA pyramidal neurons, and (iii) feeding induced by DREADD-mediated activation of BigLEN containing AgRP neurons in the arcuate nucleus. The role of GPR171 in anxiety-like behavior or fear conditioning was evaluated following systemic or intra-BLA administration of MS0021570_1, as well as following lentiviral-mediated knockdown of GPR171 in the BLA. We find that systemic administration of MS0021570_1 attenuates anxiety-like behavior while intra-BLA administration or knockdown of GPR171 in the BLA reduces anxiety-like behavior and fear conditioning. These results indicate that the BigLEN-GPR171 system plays an important role in these behaviors and could be a novel target to develop therapeutics to treat psychiatric disorders.

The effect of stereotype threat on older people’s clinical cognitive outcomes: investigating the moderating role of dementia worry

Objective: Numerous studies have shown that stereotype threat (ST) reduces older people’s cognitive performance, but few have studied its impact on clinical cognitive outcomes. Our study was designed to further examine the impact of ST on the clinical assessment of older subjects’ cognitive functioning, as well as the moderating role of fear of Alzheimer’s Disease (AD) (or ‘dementia worry’). Method: Seventy-two neurologically normal (MMSE > 26) participants aged between 59 and 70 completed a set of neuropsychological tasks in either an ST or a positive condition (condition in which negative stereotypes were invalidated). Results: Regression-based path analyses showed that only participants who expressed moderate or high fear of AD underperformed on executive tasks in the ST condition compared to their counterparts in the positive condition. Moreover, in the ST condition, participants’ performance on executive tasks was more impaired (relative to normative data) than in the positive condition. However, ST had no effect on memory and attention performance. Discussion: Our results showed that ST can cause older people to perform at pathological levels on executive tasks. Results highlight the need for clinicians to be cautious when conducting neuropsychological assessments of older people who express high levels of dementia worry.

Klytaimestra Tyrannos: Fear and Tyranny in Aeschylus's Oresteia (with a Brief Comparison with Macbeth)

In the logic of tragedy, Clytemnestra represents the distorted anti-model in regard to gender-role and political behavior. In contrast to male, just kingship, she establishes a tyranny, together with her lover Aegisthus, after killing Agamemnon. But haunted by fears from the very beginning of the Oresteia , she attempts to calm down the negative forces. First she orders sacrifices all over the city to placate the gods. In a brutal logic she devises the revenge on her returning husband. Acting as Erinys herself, her desire to shed blood is greater than rational restraint. After the horrible deed, the chorus, changing his voice and attitude, starts a collective protest against the new ruler. Clytemnestra claims that as long as Aegisthus inflames the fire in the house, fear will stay away from it. But soon she desires to sign a treaty with the Erinys who now seeks revenge on her. Therefore she restrains her lover from violence against the people of Argos, conscious of the mechanism of Erinys. But her attempts to push the fears away are in vain. In the beginning of Choephori she is haunted by terrible nightmares. Again she recurs to placating libations, now directed to the eidolon of Agamemnon. All her strategies, in words and actions, rhetoric and ritual, are bound to fail. Her terrible dream will turn out real, providing the imagery on scene: the dragon sucking her breast will turn out to be Orestes. The ritual remains ineffective, since the agents, the chorus of the libation-bearers together with Electra, reverse the goal of their action. Entangled in fears, she must fall in her new tyrannical power. Only in the last part of the trilogy, the role of fear will be redirected against the enemies according to a new polis ideology. The contribution concludes with a brief comparative remark on Macbeth , since both Aeschylus and Shakespeare focus on the precarious state of the tyrant's power and on its subconscious basis.

Parcellation of Human Amygdala Subfields Using Orientation Distribution Function and Spectral K-means Clustering.

Amygdala plays an important role in fear and emotional learning, which are critical for human survival. Despite the functional relevance and unique circuitry of each human amygdaloid subnuclei, there has yet to be an efficient imaging method for identifying these regions in vivo. A data-driven approach without prior knowledge provides advantages of efficient and objective assessments. The present study uses high angular and high spatial resolution diffusion magnetic resonance imaging to generate orientation distribution function, which bears distinctive microstructural features. The features were extracted using spherical harmonic decomposition to assess microstructural similarity within amygdala subfields are identified via similarity matrices using spectral k-mean clustering. The approach was tested on 32 healthy volunteers and three distinct amygdala subfields were identified including medial, posterior-superior lateral, and anterior-inferior lateral.

Understanding the Relationship between Trauma Exposure and Depression among Adolescents after Earthquake: The Roles of Fear and Resilience.

Middle school students (N = 1435) were assessed 18 months after the Wenchuan earthquake using measures of trauma exposure, fear, resilience, and depression, to examine the effects of fear and resilience on the relationship between trauma exposure and depression. Fear mediated the relationship between trauma exposure and depression, whereas resilience moderated the relationship between fear and depression. These findings suggest that trauma exposure has a direct positive impact on depression, but also indirectly affects depression through fear. Moreover, fear positively predicted depression under conditions of low resilience, whereas this effect was not significant when resilience was high. These results are discussed in terms of their implications for adolescents after trauma.

Gender Role Conflict and Emotional Mid-life Crisis in Men : The Mediating Role of Fear of Intimacy

Gender Role Conflict and Emotional Mid-life Crisis in Men : The Mediating Role of Fear of Intimacy