Role In Organization Research Articles

Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behavior.

Experiencing a single severe stressor is sufficient to drive sexually dimorphic psychiatric disease development. The ventral subiculum (vSUB) emerges as a site where stress may induce sexually dimorphic adaptations due to its sex-specific organization and pivotal role in stress integration. Using a 1-hr acute restraint stress model, we uncover that stress causes a net decrease in vSUB activity in females that is potent, long-lasting, and driven by adrenergic receptor signaling. By contrast, males exhibit a net increase in vSUB activity that is transient and driven by corticosterone signaling. We further identified sex-dependent changes in vSUB output to the bed nucleus of the stria terminalis and in anxiety-like behavior in response to stress. These findings reveal striking changes in psychiatric disease-relevant brain regions and behavior following stress with sex-, cell-type, and synapse-specificity that contribute to our understanding of sex-dependent adaptations that may shape stress-related psychiatric disease risk.

Barriers and facilitators for strengthening physiotherapy services in Nepal: perspectives from physiotherapists and health providers

BackgroundPhysiotherapy provides non-invasive and non-pharmaceutical intervention for curative, rehabilitation and preventative purposes. Physiotherapy is also a central provider of health promotion. As the global burden of non-communicable diseases and chronic health conditions is rising, the importance of physiotherapy services increases. Unfortunately, physiotherapy services in low- and middle-income countries (LMICs) are generally unsatisfactory. In Nepal, the earthquake in 2015 and the COVID pandemic have clearly illuminated the importance of physiotherapy.ObjectiveThis qualitative study aimed to identify barriers and facilitators at different system levels for strengthening physiotherapy services in Nepal.MethodsForty semi-structured individual interviews were performed with different health providers. Transcribed interviews were assessed with thematic analysis. A five-level socioecological framework conceptualised multilevel determinants of barriers and facilitators.ResultsThe study revealed various factors that were potential barriers and facilitators across five different levels, namely individual (taking the lead, need for advocacy), interpersonal (lack of recognition and autonomy, networking for referrals and coordination), community (lack of knowledge and awareness, social and family support), organisational (accessibility, workplace and clinical practice, educational opportunities, role of organisations and rehabilitation centres), and public policy level (planning and implementation of policies and programs, medical hegemony, priorities). Government officials, local leaders, and clinicians, half of whom were physiotherapists, agreed on many of the same issues, where a lack of awareness of what physiotherapy is and knowledge about what physiotherapists do was central.ConclusionsThe results provide information for the development of physiotherapy by pointing out key elements that need attention. Our broad and structured investigation strategy is applicable to others for a comprehensive analysis of barriers and facilitators for physiotherapy services.

Exploring Older Adults' Perceptions of Using Digital Health Platforms for Self-Managing Musculoskeletal Health Conditions: Focus Group Study.

Digital technologies can assist and optimize health care processes. This is increasingly the case in the musculoskeletal health domain, where digital platforms can be used to support the self-management of musculoskeletal conditions, as well as access to services. However, given a large proportion of the population with musculoskeletal conditions are older adults (aged ≥60 years), it is important to consider the acceptability of such platforms within this demographic. This study aims to explore participants' opinions and perceptions on the use of digital platforms for supporting the self-management of musculoskeletal conditions within older adult (aged ≥60 years) populations and to gather their opinions on real examples. A total of 2 focus groups (focus group 1: 6/15, 40%; focus group 2: 9/15, 60%) were conducted, in which participants answered questions about their thoughts on using digital health platforms to prevent or manage musculoskeletal conditions. Participants were further presented with 2 example scenarios, which were then discussed. Interviews were audio recorded, transcribed, and analyzed thematically. Participants were aged ≥60 years and with or without current musculoskeletal conditions. Prior experience of using smartphone apps or other digital health platforms for musculoskeletal conditions was not required. Focus groups took place virtually using the Teams (Microsoft Corp) platform. A total of 6 themes were identified across both focus groups: "experiences of digital health platforms," "preference for human contact," "barriers to accessing clinical services," "individual differences and digital literacy," "trust in technology," and "features and benefits of digital health technologies." Each theme is discussed in detail based on the interview responses. The findings revealed that most participants had some existing experience with digital health platforms for preventing or managing musculoskeletal conditions. Overall, there was a lack of trust in and low expectations of quality for digital platforms for musculoskeletal health within this age group. While there was some concern about the use of digital platforms in place of in-person health consultations, several benefits were also identified. Results highlighted the need for better communication on the benefits of using digital platforms to support the self-management of musculoskeletal conditions, without the platforms replacing the role of the health care professionals. The concerns about which apps are of suitable quality and trustworthiness lead us to recommend raising public awareness around the role of organizations that verify and assess the quality of digital health platforms.

Compound heterozygous mutations of NTNG2 cause intellectual disability via inhibition of the CaMKII signaling

Netrin-G2 is a membrane-anchored protein and is known to play critical roles in neuronal circuit development and synaptic organization. In this study, we identify compound heterozygous mutations of c.547delC, p.(Arg183Alafs∗186) and c.605G > A, p.(Trp202∗) in NTNG2 causing a syndrome exhibiting developmental delay, intellectual disability, hypotonia, and facial dysmorphism. To elucidate the underlying cellular and molecular mechanisms, CRISPR-Cas9 technology is employed to generate a knock-in mouse model expressing the R183Afs and W202X mutations. We report that the Ntng2R183Afs/W202X mice exhibit hypotonia and impaired learning and memory. We find that the levels of CaMKII and p-GluA1Ser831 are decreased and excitatory postsynaptic transmission and long-term potentiation are impaired. To increase the activity of CaMKII, the mutant mice have received intraperitoneal injections of DCP-LA, a CaMKII agonist, and show improved cognitive function. Together, our findings reveal molecular mechanisms of how NTNG2 deficiency leads to impairments of cognitive ability and synaptic plasticity.

Guardian of society: Civil society in Nigeria's response to COVID-19 pandemic.

The rapid breakout and dissemination of the coronavirus disease 2019 (COVID-19) infection from the city of Wuhan, China, to the rest of the countries of the world in December 2019 triggered a situation that led the World Health Organization to report it as a global public health emergency. The pandemic resulted in abrupt and significant loss of lives, disruption of economies, loss of livelihoods, and severe hardship across the nations of the world. Nigeria encountered the COVID-19 reality following the discovery of the first case of the infection in the country on February 27, 2020, prompting the government to swing into action to contain its spread. However, the government's response to the pandemic benefited from the support of nonstate actors from the profit and nonprofit sectors. This study, thus, specifically examined the role of civil society organizations (CSOs) in Nigeria's response to the coronavirus crisis. Using data obtained through secondary sources and analysis of thematic and descriptive-interpretive methods, the study found that CSOs impressively contributed to the government's fight against COVID-19, particularly in view of their roles in creating awareness about the virus and rebutting disinformation regarding the disease, among others. Yet, CSOs encountered some problems while undertaking these roles, prominently the closure of the civic space, noninclusion of CSOs in government's pandemic response architecture, and loss of funding. The study recommends, among other things, that in the case of any future public health emergencies of COVID-19 magnitude, the Nigerian Government should make CSOs an integral part of its response structure, while concluding that the application of these measures would incentivize better contributions from CSOs.

Interplay of chromatin organization and mechanics of the cell nucleus

The nucleus of eukaryotic cells is constantly subjected to different kinds of mechanical stimuli, which can impact the organization of chromatin and, subsequently, the expression of genetic information. Experiments from different groups showed that nuclear deformation can lead to transient or permanent condensation or decondensation of chromatin and the mechanical activation of genes, thus altering the transcription of proteins. Changes in chromatin organization, in turn, change the mechanical properties of the nucleus, possibly leading to an auxetic behavior. Here, we model the mechanics of the nucleus as a chemically active polymer gel in which the chromatin can exist in two states: a self-attractive state representing the heterochromatin and a repulsive state representing euchromatin. The model predicts reversible or irreversible changes in chromatin condensation levels upon external deformations of the nucleus. We find an auxetic response for a broad range of parameters under small and large deformations. These results agree with experimental observations and highlight the key role of chromatin organization in the mechanical response of the nucleus.

International actors and national policies: the introduction of the national care system in Uruguay

This paper aims to understand coalition building between national and international actors in the context of an emerging subsystem. In applying the Advocacy Coalition Framework to the case of Uruguay, where a new field of social policy – the National Care System – was introduced in 2015 after a process involving different national actors from academia, civil society, politics, and administration, but also United Nations agencies, the paper explores the role of these international organizations in coalition building, and examines how a dominant coalition of national and international actors shaped the development of the new system. Using interview data and documents, the findings suggest that the involvement of international organizations in the coalition was based on shared beliefs and personal and institutional relationships. While powerful opposing coalitions were absent due to the nascent nature of the subsystem, the dominant coalition was able to influence the policy’s introduction based on their beliefs regarding gender equality and rights.

Mordva materjal Eesti kogudes ja mordva diasporaad Eestis 20. sajandi lõpus ja 21. sajandi alguses

This article focusing on Mordvin material in Estonian collections and Mordvin (Erzya-Moksha) diasporas in Estonia in the late 20th–early 21st centuries is based mainly on materials collected in the period between 1994 and 2016 from the journal KUDO published by the Estonian Mordvin Society and reflecting the diverse life of the diaspora. We have also analysed recorded biographical data of Erzya and Moksha people residing in the Republic of Estonia and the archival material of the Estonian Mordvin Society. The article reviews the history of the first settlers, their number, formation of cultural societies and their interaction with other organisations, integration into Estonian society, information about the first Estonian expeditions to the settlements of the Erzya and Moksha as well as cultural and educational ties between Estonia and Mordovia. All this reveals the activities of compatriots, trends in population change in this group, mechanisms of the preservation of national identity and the role of Mordvin national and cultural non-profit organisations in the preservation and development of ethnic culture in the Republic of Estonia.

How Can Family Businesses Balance Dynamic Change and Resilience? The Role of a Learning Organization

How Can Family Businesses Balance Dynamic Change and Resilience? The Role of a Learning Organization

Polychronic Time Management and Employee Burnout: Supportive Roles of Organization and Supervisor

Polychronic Time Management and Employee Burnout: Supportive Roles of Organization and Supervisor

Shifting Organizational Roles in Creating Exceptional Strategic Performance

Shifting Organizational Roles in Creating Exceptional Strategic Performance

Factors Influencing Information Security Policy Compliance Behavior in High Education Institutions: Systematic Literature Review

Information security policies and behaviors play a crucial role in organizations, particularly in higher education institutions. These policies outline guidelines and best practices to protect sensitive data, safeguard privacy, and prevent unauthorized access or misuse of information. In higher education institutions, they help secure research findings, intellectual property, and student records. By fostering a culture of security awareness and encouraging responsible behavior, organizations can safeguard their reputation, instill trust, and meet legal and regulatory requirements. This literature review has revealed challenges and highlighted the current trends of information security policy compliance, as well as the theories used for information security compliance from 2013 to 2023. Out of 50 research papers published on the topic of information security policy compliance, three influencing factors were identified through filtration: behavioral intention, awareness and culture, and human with organizational management. The findings show that there is a lack of information security policies in the higher education sector. This review contributes to the information security literature by providing a fully organized systematic review of conducted research in the last decade.

RABIES: UNITING FOR ONE HEALTH - PROTECTING HUMANS AND ANIMALS TOGETHER

This review article elucidates the intricate dynamics of rabies and its effects in the context of a persistent global threat using the One Health approach. This article emphasizes the inescapable link between human, animal, and environmental health by clarifying the complex mechanisms of rabies transmission, elaborating on its symptoms and course, and demonstrating its global occurrence and impact. This article highlights the crucial importance of zoonotic diseases, notably the reservoir role of animals in rabies transmission, and embraces the idea of One Health, which recognizes the symbiotic interactions between these domains. This study highlights the significance of unified control and surveillance systems from a strategic perspective. This emphasizes the value of vaccination as a cornerstone for safeguarding both human and animal populations. Additionally, it highlights the potential of interdisciplinary One Health initiatives to eradicate rabies through successful case studies. This article sheds light on the crucial role of international organizations, the significance of policy advocacy, strict regulation, and international cooperation while addressing socioeconomic consequences, implementation challenges, and the goals of a rabies-free world. Interdisciplinary research has emerged as a catalyst to develop innovative prevention and control methods that are strengthened by technology, shared knowledge, and resilient strategies to combat the effects of climate change and emerging diseases. Public engagement, education, and community empowerment should be implemented to establish a proactive approach to rabies prevention. It concludes with a loud appeal for coordinated One Health initiatives to build a safer future in the face of this ongoing issue.

The legal basis fot the application of patent waiver settlements in the covid-19 pandemic

Background: The research on the role of the World Trade Organization in solving the vaccine patent waiver problem related to the 2019 coronavirus disease pandemic will address each issue one by one. Seeing the waiver applications that were made from the end of 2020 to 2022, it is necessary to further study the legal basis and enforcement of patents. Coupled with its relation to public health and equality for the global world to achieve. This study aims to provide an understanding of the role of the WTO in the patent waiver application process and the continuity of current and future patent law enforcement. Method: This research is a normative research with a descriptive method that will explain with the aim of obtaining a description of the events of the patent waiver application. The data that has been obtained will be analysed qualitatively. Conclusions will be obtained from various descriptive data collected from primary and secondary sources that have been analysed. In this regard, this research will be descriptive-analytical in nature which will reveal existing regulations and their implementation. Findings: The results of this study are that the WTO has carried out its roles and functions in accordance with applicable international legal instruments. However, this research emphasises further on the principles of the WTO itself which emphasises justice for developing and less developed countries on the other words called Special and Differential Treatment of Developing Countries (SDT). Coupled with the existence of the Doha Declaration which should emphasise that public health should take precedence over intellectual property rights, including patents. Conclusion: Regarding the WTO's role in resolving vaccine patent issues during the COVID-19 pandemic, it can be concluded that the actions taken by the WTO, including its internal bodies and councils, adhere to applicable legal principles and the TRIPs Agreement. However, the decisions must fully align with the WTO's principles, particularly the Special and Differential Treatment of Developing Countries (SDT). Novelty/Originality of this study: This study analyzes the role of the WTO in resolving vaccine patent issues during the COVID-19 pandemic, focusing on the SDT principles and the Doha Declaration. It reveals the gap between international law and global health needs, offering a framework for balancing intellectual property rights with public health needs.

EFFECTIVENESS OF REGIONAL POLITICAL ORGANIZATIONS IN INTERNATIONAL RELATIONS IN THE CONTEXT OF GLOBALIZATION

This article examines the impact of globalization on the development and functioning of regional political organizations in international relations. It analyses the effectiveness of regional political systems amidst globalized processes, focusing on mechanisms of interaction and coordination that contribute to regional stability and development. The study also identifies key challenges and threats these organizations face in the context of globalization. Additionally, the research aims to develop recommendations for enhancing the efficiency of regional political systems through optimizing existing cooperation and integration strategies.The study adopts an interdisciplinary approach, incorporating analysis of historical development of regional political systems, examination of contemporary political and economic processes, and analysis of specific activities of key regional organizations. The relevance of the study is underscored by the necessity to understand the effectiveness of regional political organizations in addressing global challenges. The scientific novelty lies in the comprehensive analysis of the interaction between regional organizations and global structures, emphasizing their role in contemporary international relations. The research highlights the role of regional political organizations as intermediaries between national states and global structures. It identifies these organizations as facilitators in conflict resolution, economic integration, and stability. The study assesses both positive and negative aspects of globalization for regional political organizations, along with the challenges they encounter.Practical implications of this work include providing recommendations to enhance the effectiveness of regional political organizations in a globalized world. These recommendations are valuable for policymakers, analysts, and international organizations engaged in regional cooperation and global governance. The article significantly contributes to understanding the role of regional political organizations in the contemporary international landscape, emphasizing their importance in addressing global issues and ensuring international stability. The findings of the study open new perspectives for further research and development of management strategies in these contexts.

BLOCKCHAIN TECHNOLOGIES IN INTERNATIONAL RELATIONS: FUNCTIONAL FEATURES AND CAPABILITIES

International relations today require additional functional capabilities to enhance transparency, security, and efficiency in various areas, from interactions between national political actors to intergovernmental cooperation. Due to its functional features, blockchain technology can improve and simplify international cooperation through decentralization and the absence of a central controlling body; transparency, which allows all network participants to have equal access to identical information; immutability and data security, as information cannot be changed or deleted without the consent of all network participants; and automation through smart contracts that automatically execute upon the agreed conditions. Improving blockchain understanding is possible through various international programs involving stakeholders, with international relations being one of the important areas. Coordination and alignment of political components between countries to create common standards will promote the global implementation of certain standards and norms for blockchain and international cooperation. This will create a clear environment for implementing information and communication technologies aimed at developing the potential of politicians, civil servants, international players, government institutions, the private sector, and other stakeholders. However, the adoption of blockchain in many countries will require a review of the legal framework, the adoption of new norms, and the possible repeal of certain laws. The role of international organizations in the blockchain industry will grow, as most governments still lack clear policies on the technology, while the private sector is already actively promoting it. Ultimately, the widespread use of blockchain as a digital technology tool in modern international relations can lead to fundamental changes in various fields, from trade and finance to intellectual property protection and political stability. The article discusses the problems of using blockchain technology in international relations with the disclosure of its functional features and further opportunities for improving cooperation at the interstate level.

Empowering and Building the Capabilities of Mid-Level Health Service Managers to Lead and Support the Health Workforce-A Study Protocol.

(1) Background: Mid-level managers in healthcare are central to improving safety and quality of care. Their ability in demonstrating leadership and management competency in their roles and supporting frontline managers and frontline staff has a direct effect on staff retention and turn-over. Yet, investment in their professional development and support for mid-level managers is often neither adequate nor effective, and high rates of staff turnover are evident. This study, set in northern Queensland, Australia, takes a strength-based approach to explore the role and strengths of mid-level managers and organisations' existing mechanisms in supporting managers. With broad involvement and contribution from managers at different management level and frontline staff, the project will identify strategies to address the challenges mid-level managers face while building on their capabilities. (2) Methods: Using co-design principles, a situation analysis approach will guide a mixed-methods, multiphase design. Qualitative data will be collected using transcripts of focus groups and quantitative data will be collected by surveys that include validated scales. (3) Results: Thematic analysis of the transcripts will be guided by the framework of Braun and Clarke. Quantitative data will employ descriptive and inferential analysis, including chi-squared, t-tests, and univariate analyses of variance. (4) Conclusions: This study will generate evidence to guide two partner organisations, and other similar organisations, to develop strategies to improve support for mid-level managers and build their capabilities to support and lead frontline managers and staff. Competent mid-level managers are critical to high-quality patient care and improve the outcomes of the population they serve.

A technology‐enabled framework for stakeholder engagement in a destination management system: Evidence from DMS Puglia

AbstractIn tourism, the presence of different stakeholders, sometimes with conflicting interests, requires a clear understanding of how to manage and engage them effectively. Despite the importance of this topic, tourism studies lack a univocal framework for destinations aiming to develop a destination management system (DMS) focused on empowering stakeholder engagement. To fill this gap, this study aims to identify the key dimensions that can strengthen stakeholder engagement in the tourism sector. Particular attention is given to the role of technology in mediating relationships among DMS participants and to the role of ‘intermediary’ stakeholders in facilitating collaboration and engagement. By adopting a cross‐disciplinary approach that integrates stakeholder theory, stakeholder engagement and destination management, and by examining a case study of an Italian best practice, DMS Puglia, a technology‐enabled framework for stakeholder engagement in a DMS was elaborated. This study contributes to the advancement of the literature on stakeholder engagement in tourism by demonstrating that the structure and composition of a DMS, and the communication methods it enables, along with the role of the destination management organisation and the preparedness of stakeholders to participate in a DMS, significantly influence stakeholder engagement and can strengthen relationships among participants in a technologically advanced tourism system. This study also provides directions to stakeholder bridges about how to effectively improve stakeholder engagement through technology‐focused tools and strategies.

What is meant by the term tertiary education? Past developments and recent activity

ABSTRACT The term tertiary education has gained prominence in recent policy debates in the UK [Morgan (2023). “Labour ‘would review whole landscape’ of tertiary education.” Times Higher Education, 28 November. https://www.timeshighereducation.com/news/labour-would-review-whole-landscape-tertiary-education]. This paper presents findings from a review of the use of the term in academic and policy papers in the UK over the last 80 years. The analysis reveals the role of international organisations in defining this term initially as a synonym for post-compulsory education before using it as a statistical measure which became a normative guide for many member states. More recently, the term tertiary education has been used as a descriptor of systems of educational governance and by the World Bank for specific systems of organisation. Using these definitions as a guide, the review demonstrates differences in government policy in the four nations of the United Kingdom: England, Northern Ireland, Scotland and Wales. Here there is evidence of periodic and partial policy change, but little sustained full engagement with this agenda. The review suggests that if future tertiary education policy initiatives are introduced they should cover all potential learners once they have left the compulsory phase of education and should be advanced by regional bodies with involvement from learners, employers and community representatives allocating funds from a single tertiary education budget.

The Inaction of International Organizations in Times of War

The role of international organizations in wartime has attracted much attention. However, despite the existence of international organizations, there are still many wars and conflicts in the international community. This article explores the limitations of international organizations and the reasons for the inaction of international organizations during wartime, including international law, the political will of member states, and the ability to act. This article will start from a historical perspective, review the establishment of some early international organizations, the development of international law and its role, and then analyze the role of the United Nations as a modern international organization in depth. This article will further examine how international organizations should play a more active role in the conflict by comparing it to a successful case of international organizations in conflict resolution - the Sudan and Ethiopia conflicts. Finally, this article will discuss some possible solutions to improve the role of international organizations in wartime.