Forty or fifty years ago the roentgenologic picture of disseminated pulmonary disease usually was thought to mean tuberculosis. Since that time many other causes have been recognized, and an awareness of the wide variety of conditions which produce this picture has grown rapidly in the past quarter of a century. In 1938, for example, King (1) catalogued 10 possible causes, in 1942 Austrian and Brown (2) enumerated 22, in 1948 Felson and Heublein (3) counted 75, and by 1952 Scadding (4) had raised the figure to 80. For purposes of classification the numerous conditions may be subdivided into seven groups: infections, inhalations, aspirations, vascular diseases, systemic diseases and pulmonary diseases of uncertain etiology, neoplasms, and allergies. With the growing recognition of the many entities producing a roentgenologic appearance of disseminated pulmonary disease has come the realization that the information gained from the clinical history, the physical examination, and the routinely available laboratory procedures is often insufficient to provide a definite diagnosis. Surgical procedures designed to obtain tissue for histologic, bacteriologic, and chemical examination have been employed, including bronchoscopic biopsy, biopsy of the scalene group of lymph nodes, and direct biopsy of the lung. Biopsy of the lung is seldom used unless all other means have failed to provide a diagnosis. Pulmonary tissue may be obtained in several ways; for example, by needle biopsy, by the limited biopsy procedure described by Klassen (5), and by means of formal thoracotomy. Needle biopsy is hazardous, sometimes causing hemorrhage or pneumothorax, and frequently it fails to furnish sufficient material for adequate examination (6). The limited biopsy of Klassen, employing a small intercostal incision, usually in the third or fourth interspace anteriorly on the right, provides an adequate specimen and accessibility to all portions of the right lung. Formal thoracotomy has the added advantage of allowing gross inspection of the entire lung, thereby insuring that tissue will be obtained from the most advantageous site. In a limited number of cases, therefore, biopsy of the lung provides a definite diagnosis which is useful in planning treatment, in determining prognosis, and in solving the medicolegal problems of patients subjected to occupational hazards. At the Mayo Clinic, from Jan. 1, 1950, to Dec. 31, 1955, biopsy of the lungs was employed in 34 cases of disseminated pulmonary disease. In each instance the results of other methods of diagnosis had been inconclusive, including 17 cases in which exploration of the scalene group of lymph nodes had given negative results. In all 34 cases tissue was obtained by formal thoracotomy.
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