Abstract In May 2018, the European Commission unveiled a medium-term strategic action plan as part of the Europe on the Move package, as well as a novel approach to road safety policy. In the long run, the European Union’s Vision Zero initiative has maintained an ambitious target of nearly zero fatalities by 2050. This mindset must grow stronger than it has been in the past, both among decision-makers and in society. The European Union Council, facilitating the Valletta Declaration on Road Safety of March 2017, set, for the first time, an important road safety target of halving the number of serious injuries across all EU countries by 2030, using 2020 as their benchmark. Road accidents are those quiet criminals since they often go unreported in our culture. Most Western countries, including EU members, boast some of the world’s safest roadways. In this connection, they aid other less developed European nations by emphasizing the knowledge acquired in this sector for their growth and advocating the highest possible standards on a worldwide scale. When compared to other continents, Europe is performing well in this regard, owing to decisive action at all levels, including national, regional, and municipal. At the European level, cumulative road accidents kill around 500 people every week. Deaths in other modes of transportation are no longer tolerated, and deaths on the road are no longer acceptable, and this concept must be integrated into the road safety decision-making process. It is absolutely crucial, and also required, to adopt the Safe System at the EU level as soon as possible. The scientific study includes specific research undertaken by the authors to apply various technological and managerial principles, in which correct and up-to-date facts and numbers concerning road safety and its management at the European level are provided. Those interested can thus become acquainted with the current state of play in the field approached about the new safety systems on vehicles, which have become mandatory for all car manufacturers in Europe as of January 1, 2022, but also about how these systems intervene to ensure the safety of the occupants of a vehicle. Finally, the results and future research and development directions are discussed.