Risk Factors For Knee Osteoarthritis Research Articles

Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial.

Obesity is a primary risk factor for knee osteoarthritis (OA). Prebiotics enhance beneficial gut microbes and can reduce body fat and inflammation. Our objective was to examine if a 6-month prebiotic intervention improved physical function in adults with knee osteoarthritis and obesity. We also measured knee pain, body composition, quality of life, gut microbiota, inflammatory markers, and serum metabolomics. Adults (n = 54, mostly women) with co-morbid obesity (BMI > 30kg/m2) and unilateral/bilateral knee OA were randomly assigned to prebiotic (oligofructose-enriched inulin; 16g/day; n = 31) or isocaloric placebo (maltodextrin; n = 21) for 6months. Performance based-tests, knee pain, quality of life, serum metabolomics and inflammatory markers, and fecal microbiota and short-chain fatty acids were assessed. Significant between group differences were detected for the change in timed-up-and-go test, 40m fast paced walk test, and hand grip strength test from baseline that favored prebiotic over placebo. Prebiotic also reduced trunk fat mass (kg) at 6months and trunk fat (%) at 3months compared to placebo. There was a trend (p = 0.059) for reduced knee pain at 6months with prebiotic versus placebo. In gut microbiota analysis, a total of 37 amplicon sequence variants differed between groups. Bifidobacterium abundance was positively correlated with distance walked in the 6-min walk test and hand grip strength. At 6months, there was a significant separation of serum metabolites between groups with upregulation of phenylalanine and tyrosine metabolism with prebiotic. Prebiotics may hold promise for conservative management of knee osteoarthritis in adults with obesity and larger trials are warranted. Clinicaltrials.gov/study/NCT04172688.

Association between Sarcopenic Obesity and Knee Osteoarthritis: A Narrative Review

Sarcopenia and obesity have been studied independently as risk factors for knee osteoarthritis. However, there is now research interest in investigating whether the co-existence of sarcopenia and obesity (sarcopenic obesity) within the same individual significantly increases the risk of knee osteoarthritis, compared to sarcopenia or obesity alone. This review synthesises current literature to explore the association between sarcopenic obesity and knee osteoarthritis, emphasising both the clinical evidence and existing gaps. We highlight the challenges and progress in defining sarcopenic obesity and discuss the impact that the lack of a consensus definition of sarcopenic obesity has on comparing outcomes of studies investigating the relationship between sarcopenic obesity and knee OA. We offer methodological insights to guide future studies investigating whether sarcopenic obesity increases the risk of knee osteoarthritis above and beyond the risk associated with each condition on its own. The implications for clinical practice are discussed, including the need to incorporate effective resistance exercise into weight loss programs for individuals with sarcopenic obesity. This is critical as a general weight loss program alone among individuals with sarcopenic obesity can include substantial loss of muscle mass, potentially predisposing patients to further functional decline.

The Genetic Markers of Knee Osteoarthritis in Women from Russia.

Osteoarthritis is a chronic progressive joint disease that clinically debuts at the stage of pronounced morphologic changes, which makes treatment difficult. In this regard, an important task is the study of genetic markers of the disease, which have not been definitively established, due to the clinical and ethnic heterogeneity of the studied populations. To find the genetic markers for the development of knee osteoarthritis (OA) in women from the Volga-Ural region of Russia, we conducted research in two stages using different genotyping methods, such as the restriction fragment length polymorphism (RFLP) measurement, TaqMan technology and competitive allele-specific PCR-KASPTM. In the first stage, we studied polymorphic variants of candidate genes (ACAN, ADAMTS5, CHST11, SOX9, COL1A1) for OA development. The association of the *27 allele of the VNTR locus of the ACAN gene was identified (OR = 1.6). In the second stage, we replicated the GWAS results (ASTN2, ALDH1A2, DVWA, CHST11, GNL3, NCOA3, FILIP/SENP1, MCF2L, GLT8D, DOT1L) for knee OA studies. The association of the *T allele of the rs7639618 locus of the DVWA gene was detected (OR = 1.54). Thus, the VNTR locus of ACAN and the rs7639618 locus of DVWA are risk factors for knee OA in women from the Volga-Ural region of Russia.

Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study

There is evidence that physical activity (PA) has a long-term positive impact on disease. Whether PA is a risk factor for knee osteoarthritis (OA) is still controversial. The purpose of this study was to explore whether there is a causal relationship between PA and knee OA. We extracted PA and knee OA data from genome-wide association study (GWAS) databases. We used single-nucleotide polymorphisms (SNPs) as instrumental variables. We performed MR analysis by random-effects inverse-variance weighting (IVW), MR‒Egger, weighted median, simple mode, and weighted mode methods. We evaluated the stability and reliability of the results through sensitivity analysis. There was no significant association between PA and knee OA (p > 0.05). We did not detect any pleiotropy (MR‒Egger intercept test et al.: p > 0.05). The sensitivity analysis confirmed our results (p > 0.05). There is no causal relationship between PA and knee OA.

Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis.

Diabetes mellitus (DM) has been suggested as a potential risk factor for knee osteoarthritis (KOA), and its underlying mechanisms remain unclear. The infrapatellar fat pad (IPFP) contributes to OA through inflammatory mediator secretion. Mast cells' (MCs) role in diabetic IPFP pathology is unclear. In 156 KOA patients, hemoglobin A1c (HbA1c) was stratified (HbA1c ≥ 6.5, n = 28; HbA1c < 6.5, n = 128). MC markers (TPSB2, CPA3) in IPFP were studied. Propensity-matched cohorts (n = 27 each) addressed demographic differences. MC-rich fraction (MC-RF) and MC-poor fraction (MC-PF) were isolated, comparing MC markers and genes elevated in diabetic skin-derived MC (PAXIP1, ARG1, HAS1, IL3RA). TPSB2 and CPA3 expression were significantly higher in HbA1c ≥ 6.5 vs. <6.5, both before and after matching. MC-RF showed higher TPSB2 and CPA3 expression than MC-PF in both groups. In the HbA1c ≥ 6.5 group, PAXIP1 and ARG1 expression were significantly higher in the MC-RF than MC-PF. However, no statistical difference in the evaluated genes was detected between the High and Normal groups in the MC-RF. Elevated TPSB2 and CPA3 levels in the IPFP of high HbA1c patients likely reflect higher numbers of MCs in the IPFP, though no difference was found in MC-specific markers on a cell-to-cell basis, as shown in the MC-RF comparison. These findings deepen our understanding of the intricate interplay between diabetes and KOA, guiding targeted therapeutic interventions.

TINGKAT PENGETAHUAN LANSIA TERHADAP OSTEOARTHRITIS KNEE DI POSYANDU ANGGREK TUNJUNG SEKAR

Osteoarthritis of the knee is a degenerative joint disease characterized by pathological symptoms in the entire joint structure, cartilage damage, development of osteophytes and sclerosis at the edges of the bones, stretching of the joint capsule, inflammation and weakness. the muscles around the joint. Risk factors for knee osteoarthritis are genetics, age, gender, obesity and metabolic disorders. This study aims to determine the level of knowledge of elderly people regarding knee osteoarthritis. This type of research uses outreach and poster methods as output results. Before being given counseling, 0% of the 10 respondents did not know information related to knee osteoarthritis, but after being given the counseling, 100% of the 10 respondents were able to answer all questions in the questionnaire correctly. There is a difference in respondents' knowledge before and after being given education about knee osteoarthritis.

Edukasi Lansia Sehat Bebas Osteoarthritis Lutut di Posyandu Teratai Keprabon

The elderly are an age where degenerative diseases often occur, one of the diseases suffered by the elderly is knee osteoarthritis. Knee osteoarthritis (OA) is a degenerative and progressive disease that attacks the knee joints resulting in functional limitations in the elderly. Knee osteoarthritis is caused by an unhealthy lifestyle, lack of exercise, and body weight which are risk factors for knee osteoarthritis. At the posyandu Teratai Keprabon, many elderly people complained of knee pain. This activity is an outreach regarding osteoarthritis and education regarding independent exercise to strengthen and reduce pain in the knee. This activity takes the form of providing leaflets, pre-test, post-test to measure the level of knowledge of the elderly regarding osteoarthritis. Based on the results of filling out the questionnaire, it was seen that the elderly had an increased understanding of osteoarthritis, such as signs and symptoms as well as exercises to reduce pain and strengthen muscles in the knee.

Prevalence and Associated Risk Factors of Knee Osteoarthritis in Contra-lateral Limb After Limb Amputation

Prevalence and Associated Risk Factors of Knee Osteoarthritis in Contra-lateral Limb After Limb Amputation

Psychosocial Determinants of Knee Osteoarthritis Progression: Results from the Promoting Independence in Our Seniors with Arthritis Study.

Knee osteoarthritis (OA) is a common cause of physical disability among older adults. While established risk factors for knee OA include age and increased body weight, few studies have examined psychosocial risk factors or progression of knee OA. The Promoting Independence in our Seniors with Arthritis study recruited participants aged 65 years and over from orthopedic outpatients and community engagement events. Participants were invited to annual visits during which knee OA symptoms were assessed with the Knee Injury and Osteoarthritis Outcome Score (KOOS), social network using the 6-item Lubben Social Network Scale and anxiety and depression using the Hospital Anxiety and Depression scale. Knee OA worsening was defined by a 5% reduction in mean KOOS scores at the last visit compared to the first visit. Data were available from 148 participants, mean age 66.2±6.5 years and 74.1% female, of whom 28 (18.9%) experienced OA worsening over a median follow-up period of 29 months. Univariate analyses revealed that age, sex, height, grip strength, and social network were associated with OA worsening. Social network remained statistically significantly associated with OA worsening after adjustment for age and sex difference (odds ratio=0.924; 95% confidence interval, 0.857-0.997). The relationship between social network and OA worsening were attenuated by both depression and handgrip strength at baseline. Psychological status and muscle strength may be modifiable risk factors for social network which may in turn prevent knee OA worsening and should be targeted in future intervention studies.

Plate Hooking Transtibial Medial Meniscus Posterior Root Pull-Out Repair with Medial Open-Wedge High Tibial Osteotomy for Knee Osteoarthritis with Medial Meniscus Posterior Root Tear

Medial meniscus posterior root tears (MMPRT) are a risk factor for knee osteoarthritis (KOA) because it involves disruption of the hoop structure of the meniscus. In recent years, MMPRT pullout repair has been performed to restore the native anatomy of the meniscus attachment. In addition, medial open-wedge high tibial osteotomy (MOWHTO) has been performed with MMPRT pullout repair to reduce the pressure on the medial compartment. However, it has been noted that when MMPRT pullout repair and HTO are performed simultaneously in a patient, the locking screws of the plate interfere with the tibial bone tunnel, which damages the suture. In this technical note, we developed a method to reduce the probability of interference by placing the plate further anteroinferior when digging the bone tunnel from the PM position. This technical note aimed to provide a comprehensive description of the safety of transtibial MMPRT repair with MOWHTO for medial KOA with MMPRT.

Relatively low fluoride in drinking water increases risk of knee osteoarthritis (KOA): a population-based cross-sectional study in China.

Previous studies indicate that fluoride in drinking water has a toxic effect on cartilage and skeleton, which triggers osteoarthritis (OA) of which the most frequent is knee OA (KOA). A cross-sectional study was conducted to assess the association between fluoride exposure and KOA among 1128 subjects. Water fluoride (WF) and urinary fluoride (UF) were chosen as external exposure (internal exposure) of fluoride. Logistic regression analysis showed that an increased fluoride exposure was a risk factor for KOA (WF: OR = 1.318, 95% CI 1.162-1.495, p < 0.001; UF: OR = 1.210, 95% CI 1.119-1.310, p < 0.001). After adjusting for covariates, the risk of KOA in the 4th quartile (Q) of WF was twice that of the 1st Q (OR = 2.079, 95% CI 1.448-2.986, p < 0.001). The risks of KOA in the 2nd Q, 3rd Q and 4th Q of UF were 1.6, 1.5, and 2.9 times higher than in the 1stQ (OR = 1.597, 95% CI 1.066-2.393, p = 0.023; OR = 1.560, 95% CI 1.043-2.333, p = 0.030; OR = 2.897, 95% CI 1.957-4.288, p < 0.001). The population aged < 60 exposed to the 4th Q of WF (or UF) had a higher risk than the population exposed to the 1st Q of WF (or UF) (ORWF = 1.958, 95% CI 1.249-3.070, p = 0.003; ORUF = 2.923, 95% CI 1.814-4.711, p < 0.001). With increasing UF by Q, the male had a risk of KOA. In conclusion, excessive fluoride dose in drinking water could increase the risk of KOA. Especially, the population with aged < 60, male and obesity more likely to having KOA when they exposed to same higher fluoride.

Physical Activity for Osteoarthritis: A Cross-Sectional Study

Background. Physical activity is a fundamental and proactive form of conservative treatment for persons with knee osteoarthritis. Study purpose. This study aims to investigate risk variables for individuals in Indonesia who had knee osteoarthritis (OA). Materials and methods. This study’s cross-sectional study design employed an observational analytical approach. The samples obtained using Slovin’s formula contained as many as 66 respondents. The study’s dependent variables were the primary and secondary types of knee OA. Results. The study’s dependent variables were the primary and secondary forms of knee OA. 43 patients experienced the primary knee OA, while 23 experienced the secondary OA. The logistic regression test used age (p=0.011), gender (p=0.021), body mass index (p=0.027), history of knee injury (p=0.001), hypertension (p=0.023), hypercholesterolemia (p=0.112), and physical activity (p=0.004) as independent variables. These variables also met the criteria to be incorporated into the multivariate analysis with a p value less than 0.25. The biggest risk factor for knee OA was found to be age (OR=1.923; p=0.011; p=0.011). Knee OA is significantly influenced by age, gender, BMI, a history of knee injuries, and physical activity. Conclusions. Increased physical activity is necessary for those with knee osteoarthritis. Patients with knee osteoarthritis should be treated by healthcare professionals who are aware of their physical activity habits, especially those at risk.

Visualization of lateral meniscus extrusion during gait using dynamic ultrasonographic evaluation.

Medial meniscus extrusion is one of the risk factors for knee osteoarthritis (OA). However, lateral meniscus extrusion has not been discussed, and detailed information remains unknown. In particular, the lateral meniscus has high mobility and is expected to be difficult to evaluate in terms of its behavior under static conditions. Dynamic ultrasonographic evaluation was introduced to detect the dynamic behavior of the meniscus during walking. In this study, we aimed to investigate the behavior of the lateral meniscus during walking using dynamic ultrasonographic evaluation. Sixteen participants with knee OA were recruited in this study. The change of lateral meniscus extrusion during walking was recorded using ultrasonography. Medial and lateral meniscal extrusion during the stance phase was measured, and meniscal mobility was defined as the difference in meniscal extrusion between minimum and maximum values (mm), medial meniscal extrusion (∆MME), and lateral meniscal extrusion (∆LME), respectively. The walking cycle and gait forms of lateral thrust were also evaluated using three-dimensional motion analysis systems and analyzed in terms of the correlation with ∆MME and ∆LME. The lateral meniscus was depicted in the articular plane, and extrusion decreased during the stance phase of the gait cycle. The ∆LME was significantly higher than the ∆MME (p < 0.01). There was a significant positive correlation between ∆LME and lateral thrust (r = 0.62, p < 0.05). We found that dynamic ultrasonographic evaluation can be used to visualize lateral meniscus extrusion during walking, and that its behavior is correlated to the degree of lateral thrust.

Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort

ObjectiveObesity is a risk factor for knee osteoarthritis (KOA) development and progression. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are indicated for type 2 diabetes mellitus (T2DM) and obesity. However, whether KOA...

Impact of Lifestyle on Knee Osteoarthritis in Mosul Hospitals

Background &amp; Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis. It is a chronic, degenerative disease of the musculoskeletal system that causes significant disability in patients all over the world. The knee is the most commonly affected joint by OA, especially in older people. Knee OA is a painful disorder that progresses with time and affects the whole knee joint, leading to varying degrees of severe joint failure. It can cause pain, stiffness, and swelling in the knee. It can also lead to disability ,and Lifestyle factors were found to be related to knee OA. This study’s aim was to evaluate how lifestyle choices affected knee OA in patients visiting hospitals in Mosul, Iraq. The specific objectives of the study were to 1 Evaluate demographic characteristics of individuals with knee OA. 2 Discover the lifestyle factors for patients with knee OA. 3 Determine the relationship between lifestyle and the severity of knee OA. Methods: A cross-sectional study design was adopted for the period extended from the 1st of December 2022, to the 20th of July 2023. It included 500 knee osteoarthritis patients collected from consulting clinics in four teaching hospitals in Mosul, Iraq, by using a developed interviewing questionnaire that assessed sociodemographic characteristics, health history, lifestyle factors, and the severity of knee OA. Results: The mean age of patients (59.4) The majority of the participants were female (83.4%). (74.6%) of the sample were housewives, (75.4%) lived in urban. The most common risk factors for knee OA were obesity (27.2%), and family history (47.4%). (90.8%)of the patients had low education level. Patients had bilateral joint OA(right and left) were 64.6%. Most of patients have a sedentary lifestyle. There are significant association between lifestyle domains like health self-responsibility, nutrition, physical activity, stress management, and spiritual growth with joint OA severity. The highest association between lifestyle domains and severity is seen in the areas of health self-responsibility, diet, and physical exercise. Conclusion: Certain demographic and socio-demographic factors, such as age, gender, education, residency, occupation, BMI, previous knee injuries, and family history, had a significant association with knee osteoarthritis patients. This study has shown that lifestyle factors play a role in the development and severity of knee OA. Physical inactivity, poor diet, and obesity are all major risk factors for knee OA. The findings can suggest that modification of lifestyle may be a protective against knee OA. Participants who reported being more physically active, eating a healthier diet, and maintaining a healthy weight were less likely to have severe knee OA. Interventions that target lifestyle factors may be beneficial in preventing and managing knee OA. Keyword: Knee Osteoarthritis, Life-Style, Factor

The Effect of Lifestyle on Pain Intensity in Knee Osteoarthritis Patients

Background &amp; Objectives: Knee osteoarthritis (OA) is a degenerative condition that damages the cartilage in the knee joint. The cartilage is a soft, rubbery tissue that acts as a joint cushion and friction reducer. As the joint’s cartilage diminishes, the bones rub against one another, resulting in pain, stiffness, and less mobility. Knee OA is a painful disorder that progresses with time and affects the whole knee joint, leading to varying pain intensity, stiffness, and swelling in the knee. It can also lead to disability, and Lifestyle factors were found to be related to knee OA. This study’s aim was to evaluate how lifestyle choices affected knee OA in patients visiting hospitals in Mosul, Iraq. The specific objectives of the study were to:1. Evaluate the socio-demographic characteristics for knee OA patients. To identify the lifestyle factors for patients with knee OA. To assess the effect of lifestyle on the pain intensity of knee OA. Methods: A cross-sectional study design was adopted for the period extended from the 1st of December 2022, to the 20th of July 2023. It included 500 knee osteoarthritis patients collected from consulting clinics in four teaching hospitals in Mosul, Iraq, by using a developed interviewing and self-admission questionnaire that assessed sociodemographic characteristics, health history, lifestyle factors, and the pain intensity on knee OA patients. Results: The mean age of patients (59.4) The majority of the participants were female (83.4%). (74.6%) of the sample were housewives, (75.4%) lived in urban. The most common risk factors for knee OA were obesity (27.2%), and family history (47.4%). (90.8%) of the patients had low education level. 37.2% of them at severe levels of constant pain intense. 28.6% of them at moderate levels of intermittent pain. Most of patients have a sedentary lifestyle. There are significant association between lifestyle domains with joint pain intensity. Lifestyle domains, except health self-responsibility and nutrition, significantly impact constant pain in knee and Health self-responsibility is associated with intermittent pain. Conclusion: Certain demographic and socio-demographic factors, such as age, gender, education, residency, occupation, BMI, previous knee injuries, and family history, had a significant association with knee osteoarthritis patients. This study has shown that lifestyle factors play a role in the pain intensity of knee OA. Lifestyle factors, such as physical activity, stress management, and enough sleep, have been shown to be effective in managing joint pain.. The findings can suggest that modification of lifestyle may be a protective against knee OA. Participants who reported being more physically active, eating a healthier diet, and maintaining a healthy weight were less likely to have knee pain. Keyword: Knee Osteoarthritis, Life-Style, Factor

Integrin Subunit Alpha M, ITGAM Nonsynonymous SNP Is Associated with Knee Osteoarthritis among Thais: A Case-Control Study

Knee osteoarthritis (OA), which is one of the most common degenerative joint diseases, presents a multifactorial etiology, involving multiple causative factors including genetic and environmental determinants. Four human neutrophil antigen (HNA) systems can be determined using each HNA allele by single-nucleotide polymorphisms (SNPs). However, there are no data on HNA polymorphisms and knee OA in Thailand, so we investigated the association of HNA SNPs and knee OA in the Thai population. In a case-control study, detection of HNA-1, -3, -4, and -5 alleles by polymerase chain reaction with sequence-specific priming (PCR-SSP) was performed in participants with and without symptomatic knee OA. Logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (CI) between cases and controls. Among 200 participants, 117 (58.5%) had knee OA; 83 (41.5%) did not and were included as controls in this study. An integrin subunit alpha M (ITGAM) nonsynonymous SNP, rs1143679, was markedly associated with symptomatic knee OA. The ITGAM*01*01 genotype was identified as an important increased risk factor for knee OA (adjusted OR = 5.645, 95% CI = 1.799-17.711, p = 0.003). These findings may contribute to our understanding of the application prospects for therapeutic approaches to knee OA.

Levothyroxine use and longitudinal changes in thigh muscles in at-risk participants for knee osteoarthritis: preliminary analysis from Osteoarthritis Initiative cohort

BackgroundWe examined the association between levothyroxine use and longitudinal MRI biomarkers for thigh muscle mass and composition in at-risk participants for knee osteoarthritis (KOA) and their mediatory role in subsequent KOA incidence.MethodsUsing the Osteoarthritis Initiative (OAI) data, we included the thighs and corresponding knees of participants at risk but without established radiographic KOA (baseline Kellgren-Lawrence grade (KL) < 2). Levothyroxine users were defined as self-reported use at all annual follow-up visits until the 4th year and were matched with levothyroxine non-users for potential confounders (KOA risk factors, comorbidities, and relevant medications covariates) using 1:2/3 propensity score (PS) matching. Using a previously developed and validated deep learning method for thigh segmentation, we assessed the association between levothyroxine use and 4-year longitudinal changes in muscle mass, including cross-sectional area (CSA) and muscle composition biomarkers including intra-MAT (within-muscle fat), contractile percentage (non-fat muscle CSA/total muscle CSA), and specific force (force per CSA). We further assessed whether levothyroxine use is associated with an 8-year risk of standard KOA radiographic (KL ≥ 2) and symptomatic incidence (incidence of radiographic KOA and pain on most of the days in the past 12 months). Finally, using a mediation analysis, we assessed whether the association between levothyroxine use and KOA incidence is mediated via muscle changes.ResultsWe included 1043 matched thighs/knees (266:777 levothyroxine users:non-users; average ± SD age: 61 ± 9 years, female/male: 4). Levothyroxine use was associated with decreased quadriceps CSAs (mean difference, 95%CI: − 16.06 mm2/year, − 26.70 to − 5.41) but not thigh muscles’ composition (e.g., intra-MAT). Levothyroxine use was also associated with an increased 8-year risk of radiographic (hazard ratio (HR), 95%CI: 1.78, 1.15–2.75) and symptomatic KOA incidence (HR, 95%CI: 1.93, 1.19–3.13). Mediation analysis showed that a decrease in quadriceps mass (i.e., CSA) partially mediated the increased risk of KOA incidence associated with levothyroxine use.ConclusionsOur exploratory analyses suggest that levothyroxine use may be associated with loss of quadriceps muscle mass, which may also partially mediate the increased risk of subsequent KOA incidence. Study interpretation should consider underlying thyroid function as a potential confounder or effect modifier. Therefore, future studies are warranted to investigate the underlying thyroid function biomarkers for longitudinal changes in the thigh muscles.

Factors Contributing to Increase in Knee Osteoarthritis Among Young People of Multan Periphery

Objective: To determine the risk factors of knee osteoarthritis in young patients. Methods: A total of 100 patients with diagnosis of knee arthritis were included as cases and a similar number of 100 patients who presented to the orthopedic clinic for reasons other than knee arthritis were taken as controls. A study questionnaire was designed to gather information regarding the patient’s age, gender, body mass index, physical activity, smoking history and knee injury history. Results: Mean age was 39.1±6.8 years in study group and 40.2±5.7 years in control group. There were 67 (67%) male patients in cases group and 59 (59%) male patients in control group, p-value 0.24. There were 35% obese patients in cases and 13% in control group (p-value 0.0002). There were 56% smokers in cases and 41% in control group with p-value 0.03. Out of 100, 11% patients in cases and 4.0% in control group had history of knee joint injury (p-value 0.06). 47% patients in cases group and 33% patients in control group were belonged to hardworking occupations, p-value 0.04. Conclusion: Obesity, history of knee joint injury, smoking and hardworking occupation are risk factors of knee osteoarthritis in young patients. Keywords: Knee osteoarthritis, young patients, obesity, risk factors.

Knowledge and Associated Risk Factors of Knee Osteoarthritis among School Teachers at Assiut City

Knowledge and Associated Risk Factors of Knee Osteoarthritis among School Teachers at Assiut City