Risk Factors For Central Obesity Research Articles

Urban-rural differences in food consumption and central obesity among middle-aged adults: A cross-sectional population study in Indonesia

Background: The prevalence of central obesity is increasing in many regions, including low- and middle-income countries. It has been identified that a poor diet has become a significant risk factor for central obesity. However, the relationship between diet and the prevalence of central obesity among rural and urban communities remains unclear in low- and middle-income countries. Aim: This study aimed to analyze the association of food consumption with central obesity among middle-aged adults (45–59 years) in urban and rural areas in Indonesia. Methods: This was a cross-sectional study using secondary data from a national survey (Indonesia Basic Health Survey) in Indonesia in 2018. A total of 154,449 subjects were analyzed for the study. We used the International Diabetes Federation to define central obesity. Food consumption was measured using a validated food frequency questionnaire. Multivariable logistic regression was used to explore the association between food consumption and central obesity. Results: Frequent consumption of refined desserts, fried food, processed food, and inadequate consumption of fruit was significantly associated with central obesity in urban and rural areas ( p < 0.05). In contrast, frequent consumption of seasoning and inadequate consumption of vegetables was significantly associated with central obesity only in rural areas ( p < 0.05). Conclusion: Food consumption has a different association with central obesity risk in rural and urban areas in Indonesia.

Risk Factors for Central Obesity in Women 45-54 Years of Age in Indonesia (Riskesdas 2018 Analysis)

The prevalence of central obesity in Indonesia, especially in women aged 45-54 years, has increased according to the results of the Basic Health Research (Riskesdas, Riset Kesehatan Dasar). Central obesity is associated with a higher risk of diseases such as diabetes, cardiovascular disease, dyslipidemia, and hypertension. This study aimed to identify factors associated with the incidence of central obesity in women aged 45-54 years in Indonesia using the 2018 Riskesdas data with a cross-sectional study design. The study sample consisted of 60,557 individuals, with 64.54% having central obesity. Marital status (PR=1.12; 95%CI 1.09-1.15), low physical activity (PR=1.18; 95%CI 1.14-1.21), and consumption of high-risk foods (PR=1.03; 95%CI 1.01-1.05) were found to be associated with an increased risk of central obesity. In contrast, primary education (PR=0.86; 95%CI 0.83-0.89), employment status (PR=0.91; 95%CI 0.90-0.93), and smoking status (PR=0.89; 95%CI 0.84-0.95) acted as protective factors against central obesity. The results of this study suggest the need for increased nutrition education and physical activity in women aged 45-54 years as well as health support programs for married women.

Analysis on epidemiological characteristics of central obesity/pre-central obesity and influencing factors in Jilin Province

Objective: To understand the epidemiological characteristics of central obesity and pre-central obesity and influencing factors in residents in Jilin Province, and provide reference for the prevention and control of central obesity and pre-central obesity. Methods: Based on the results of early screening and comprehensive intervention program in high-risk groups of cardiovascular disease in Jilin dyring 2017-2018, a total of 11 903 participants aged 35-75 years in 6 project areas in Jilin were included as the survey subjects for physical examination, laboratory test and questionnaire survey. The prevalence of central obesity and pre-central obesity in populations with different characteristic and health status were analyzed by χ2 test, trend χ2 test, F-test. Multivariate logistic regression model was used for influencing factor analysis. Results: The central obesity rate was 33.35% (3 970/11 903), the standardized rate was 31.73%, the pre-central obesity rate was 28.79% (3 427/11 903), the standardized rate was 28.86%. Multifactor analysis results showed that being rural resident (OR=1.99, 95%CI: 1.78-2.23), being woman (OR=1.76, 95%CI: 1.57-1.97), 65-75 years old (OR=1.21, 95%CI: 1.03-1.45), senior high school and technical secondary school education level (OR=1.38, 95%CI: 1.17-1.63), annual family income >100 000 yuan (OR=1.65, 95%CI: 1.20-2.26), overweight (OR=9.27, 95%CI: 8.26-10.41), obesity (OR=82.82, 95%CI: 62.63-109.52), normal high blood pressure (OR=1.49, 95%CI: 1.27-1.74), hypertension (OR=1.70, 95%CI: 1.42-2.04), diabetes (OR=2.30, 95%CI: 1.94-2.73), dyslipidemia (OR=1.33, 95%CI: 1.18-1.50) were positively related to the risk for central obesity and pre central obesity. Conclusions: The prevalence rates of central obesity and pre central obesity in residents in Jilin were at high levels, being rural resident, being woman, older age, senior high school and technical secondary school education level, high income, overweight and obesity, normal high blood pressure and hypertension, diabetes, dyslipidemia were risk factors for central obesity and pre-central obesity in Jilin.

ASUPAN LEMAK JENUH DAN OBESITAS SENTRAL PADA IBU RUMAH TANGGA USIA 30-49 TAHUN

Central obesity is excess fat concentrated in the abdomen. One of the risk factors for central obesity is smoking, lack of physical activity, and excess fat intake. This study aims to determine the description of saturated fat intake and central obesity in housewives aged 30-49 years in Sarimahi Village, Ciparay District in 2021. The study design used in this study was cross-sectional. The number of research samples was 95 housewives aged 30-49 years in Sarimahi Village which were obtained randomly. Collecting data by measuring waist circumference, interview method using the Semi-Quantitative FFQ questionnaire to see the average consumption of saturated fat intake per day. Waist circumference data were measured using a waist circumference meter. The data was processed using univariate and bivariate analysis with a chi-square test. The results showed that 62 people (65.3%) had central obesity, as many as 65 people (68.4%) had an excess saturated fat intake, 60 people (63.17%) samples had an excess saturated fat intake with central obesity nutritional status.

Prevalence and Determinants of Central Obesity at Urban Slum Dwellers in North Jakarta

Central obesity, widely known as a major cardiovascular disease risk factor, threatens the urban poor more than other socio-economic groups. The study intended to disclose the prevalence and determinants of central obesity in urban slum dwellers in North Jakarta. We conducted a survey study on residents aged 15 and above. The study randomly recruited two hundred forty-eight residents for direct interviews and body measurements according to the minimum sample requirement. Sociodemographic and Noncommunicable Diseases (NCDs) risk factors questionnaires were used and asked after weight, height, and waist circumference measurements. Descriptive and multivariate analyses were conducted to determine the central obesity prevalence and associated determinants. The central obesity prevalence in urban slum dwellers reaches 68.1%, presiding in women (69.4%) than men (65.3%). The multivariate binary logistic regression analysis indicates that central obesity was higher in the 30-59 y.o age group (Prevalence Ratio [PR]= 1.68; 95% Confidence Interval [CI]=1.19-2.37) and ≥ 60 y.o age group (PR = 1.76; 95%CI = 1.20-1.41). Besides, the residents who do not eat fruits and vegetables daily (PR=1.20; 95%CI=1.01-1.41) and practice less physical activity (PR=1.25; 95%CI=1.01-1.56) were more likely to have central obesity. The productive age group and elderly are at a higher risk for central obesity in an urban slum. Although notable as the main risk factors for central obesity, less consumption of fruits, vegetables and lack of physical activity highlight the urgent need to provide affordable, healthier options for urban slum dwellers.

Risk Factors of Central Obesity in the Group of Tuak Drinkers and Non Tuak Drinkers Study Case Adult Male in Mataram

Central obesity occurs because of an imbalance of energy intake with energy expenditure. The cause of central obesity is excess energy intake and low physical activity. Socio-cultural influence on obesity is consuming alcoholic beverages types of tuak are now becoming a habit that is not quite right. The aim of research to analyze the risk factors of central obesity in the group of tuak drinkers and non tuak drinkers. This study was cross-sectional study. The number of subjects were 92 men divided into two groups 46 people drink tuak and 46 people do not drink tuak. Nutrient intake was measured by recall 2x24h and data on level of physical activity obtained by calculating the physical activities level (PAL). Measurement of central obesity using abdominal circumference size. Data was analyzed by counting prevalance ratio and method of logistic regressio. Based on the chi-square test, risk factors for central obesity in the group drink tuakare energy intake (p = 0.002; PR = 5.556), carbohydrate intake (p = 0.002; PR = 5.556), protein intake (p = 0.002; PR = 5.556), fat intake (p = 0.006; PR = 3.818), physical activity levels (p = 0.005; PR = 3.956) frequency of consumption of tuak (p = 0.026; PR = 3.046) and the volume of consumption of tuak (p = 0.014; PR = 3.400). The risk factors of central obesity in the group do not drink tuak are energy intake (p = 0.004; PR = 1.969), carbohydrate intake (p = 0.001; PR = 3,529), fat intake (p = 0.006; PR = 3.818) and physical activity levels (p = 0.001; PR = 4.306). The risk factors that most influence on the incidence of central obesity have excessive protein intake, frequency of consumption and the volume of tuak with a high probability of 62.77 % in the group of tuak drinkers. The risk factors that most influence on the incidence of central obesity has excess energy intake, excessive carbohydrate intake and low physical activity with a probability of 70.72 % in the group do not drink tuak.

Obstetric history and its association with cardiometabolic risk factors: a case-control study among Bhil Women of Rajasthan, India

Pregnancy and childbearing are special reproductive events having an impact on women’s health and demographic trends. Reproductive health is not only linked to biological events of gestation and birth, but also are intricately linked to women`s status and their role in society. The current study focuses on the impact of bad obstetric history in the development of cardiometabolic risk factors. The present retrospective case-control study was conducted among Bhil tribal women of Rajasthan, India. A total of 287 women participated in this study which included 125 cases and 162 controls. Data on somatometric measurements, physiological measurements and lipid profile were recorded and analysed using SPSS version 25.0. The mean number of conceptions differed significantly between pregnancy in cases (5.06±1.85) and pregnancy in controls (3.19±1.56). Cases were characterised with significantly increased mean SBP (p=0.010), although the values (116.68±23.04) fell within the normal range. Bad obstetric history was found to be a risk factor for central obesity, hypertension and dyslipidemia among the Bhil women. It was also found to be relatively associated with adverse demographic/lifestyle variables which could enhance the effect of cardiometabolic risk factors. Women with bad obstetric history need special care and lifestyle variables need to be adjusted for better health outputs.

Hypercholesterolemia as a dominant factor of central obesity among adult patients at Bojong Gede Public Health Center, Bogor Regency, Indonesia

The prevalence of central obesity has been increasing rapidly in recent decades. Central obesity, measured by waist circumference, is the most dangerous type of obesity since it is closely related to chronic diseases, metabolic complications, and high COVID-19 infection rates. The objective of this study was to identify the dominant factor of central obesity among the adult population. The study used secondary data from a 2017 cross-sectional study conducted at Bojong Gede Public Health Center, Bogor Regency, Indonesia. A total of 85 men and women aged 25–64 years old were selected through purposive sampling and included in the analysis. The association between risk factors and central obesity were measured through chi-square bivariate analysis and multiple logistic regression multivariate analysis using IBM SPSS application version 22. The prevalence of central obesity was 70.6%. The results showed that sex (women), total blood cholesterol level (hypercholesterolemia), energy, protein, fat, and carbohydrate intake (>110%personal nutritional needs) were significantly associated with central obesity (p-value < 0.05). Hypercholesterolemia was the most dominant risk factor for central obesity (p-value = 0.032; OR = 4.21; 95%CI = 1.131–15.667) adjusted for confounders.

Sugar-sweetened beverages as risk factor of central obesity among women in reproductive age

Background: Several risk factors for central obesity include high Sugar-sweetened Beverages (SSBs) intake, lack of physical activity, and lack of sleep duration. High fructose corn syrup, the sweetener used in SSBs, increase body weight because of the bad effect of insulin secretion and leptin release. The fructose from this beverage can increase visceral adiposity accumulation. Objectives: This study aimed to analyze the intake of Sugar-sweetened Beverages (SSBs), physical activity, and sleep duration as risk factors for central obesity among women in the reproductive AgeMethods: This study used case-control design consists of 38Subjects in case and control groups. All women were in childbearing age (20-29 years) selected using a simple random sampling technique. The data taken were weight, height, waist circumference, and hip circumference. Food intake and sugar-sweetened beverage intake were obtained by using Semi-Quantitative Food Frequency (SQ-FFQ) questionnaire. Physical activity data were obtained using the International Physical Activity Questionnaire (IPAQ) questionnaire. Sleep duration data were obtained using the Pittsburgh Sleep Quality Index (PSQI). Chi-Square test and logistic regression were used to analyze the data.Results: There were a significant relationship between Sugar Sweetened Beverages intake (p = 0.002, OR =5.926), energy intake of SSBs (p = 0.035, OR = 2.979) physical activity (p = 0.035, OR = 0.3111), duration of morning sleep / afternoon (p = 0.000; OR = 9.44) and sleep duration (p = 0.028, OR = 4.42) with central obesity. But there were no significant relationship between energy intake (p = 0.375), carbohydrates (p = 0.1), protein (p = 0.3), fat (p = 0.1) and fibers with central obesity.Conclusion: High intake of sugar-sweetened beverages, short duration of night's sleep and the duration>2 hours/day of a long day sleep are risk factors for increasing the incidence of central obesity among Women in reproductive Age.

Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal.

In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20–69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies.

OBESITAS SENTRAL PADA ORANG DEWASA: STUDI KOHOR PROSPEKTIF DI KOTA BOGOR

Central obesity is one of the public health problems in developing countries. This study aims to analyze the dynamic risk factors for central obesity in adults. This study used secondary data Cohort Study of Non-Communicable Diseases Risk Factors observing period for six years. The study design wa s a prospective cohort. The subjects w ere all household members aged 25 years and above with the criteri a remaining in the study area, healthy, no n- physically disabled, non-pregnant, ha ving normal abdominal circumference ( male ≤ 90 cm and female ≤80 cm) on baseline study, not suffer ing from non-communicable diseases (hypertension, diabetes mellitus, cancer, stroke, chronic obstructive pulmonary disease ) at the baseline of the study, and complete ness of the data. The number of subjects at the baseline of the study w ere 1510, consisting of 613 men and 897 women. The results showed that a cumulative incidence of central obesity during the 6-year observation period of 837 (55.4%). M ultivariate cox regression analysis showed that the risk factors for central obesity in adults were gender, age group, marital status, and physical activity. This study concluded that female subjects with physical inactivity had more central obesity compared to male subjects with physical inactivity .

Determinants of obesity in population of PURE study from Lower Silesia.

The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia. This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Each participant answered PURE questionnaire and International Physical Activity Questionnaire providing information about obesity risk factors. Anthropometric measurements were collected, blood samples were taken for assessment of FTO gene polymorphism. A stepwise logistic regression analysis was performed to identify the most significant predictors of obesity. 31% of the study group had obesity (BMI over 30 kg/m², no difference between men and women), overweight (BMI 25-29.9 kg/m²) affected 48.1% of men and 36.7% of women. Determinants of obesity in female group were: rural inhabitancy, chronic medication, unemployment, age, sedentary leisure time activity, non-smoking, hypertension in family, family related stress (p = 0.66 in the Hosmer-Lemeshow test). Determinants of obesity in male group were rural inhabitancy, chronic medication, family related stress, diabetes in family (p = 0.27 in the Hosmer-Lemeshow test). Risk factors for central obesity were similar, however in women oral contraception and physical activity were associated with lower obesity risk. Environmental factors, especially rural inhabitancy and family related stress were associated with higher obesity risk in our study. Employment, smoking, physical activity and use of oral contraception seemed to have protective role in women.

ASSOCIATION OF THE HUMAN PPARγ2 PRO12ALA POLYMORPHISM WITH OBESITY IN A POPULATION FROM TURKEY.

There have been a number of reports on the relationship between the PPARγ2 Pro12Ala genotype and the development of obesity. A case-control survey was designed to investigate the potential association between a Pro12Ala polymorphism in the PPARγ2 gene and obesity and/or obesity-related phenotypes in a population from Turkey. The polymerase chain reaction and restriction enzyme digestion were used to genotype the Pro12Ala polymorphism of the PPARγ2 gene in 149 unrelated obese and 105 non-obese control subjects from Turkey. The data were analyzed statistically. We found that the overall minor allele frequency was 0.12 in cases and 0.095 in controls. In terms of genotype distribution and allele frequencies among the cases versus controls in the population studied, only the gender-stratified analysis revealed a significantly higher frequency of Pro/Ala genotype within males. The polymorphism was associated with significantly higher weight, height, waist circumference, central adiposity (waist-to-hip ratio, WHR), lean body weight as well as dry body weight, but not overall adiposity (total body fat percentage, TBF) in cases carrying Ala allele (Pro/Ala or Ala/Ala). However, in the subjects carrying Ala allele of the control group, WHR values were found significantly lower. Our results showed that the Pro12Ala polymorphism in the PPARγ2 gene is associated with obesity in the studied adult population from Turkey. These data suggest that the Pro12Ala polymorphism in PPARγ2 may be a potential genetic risk factor for central obesity.

Prevalence and correlates of metabolic syndrome in Hong Kong Chinese adults—a random community sample study

The study investigates the prevalence and correlates of metabolic syndrome (MS) among Hong Kong Chinese adults. Random cluster sampling design and International Diabetes Federation (IDF) MS criteria were adopted. Totally 737 adults participated in questionnaire survey and received waist circumference (WC) measurement. Among them 335 showed central obesity (WC > 80 and 85 cm for women and men respectively). Subsequently 229 accepted blood test. Totally 71 participants met MS criteria, suggesting an overall prevalence of 14.1%. Both central obesity and MS increase sharply with age. Chi-square/ANOVA analyses revealed significant positive associations between central obesity with: being male, marital status being married/cohabit, lower education level, occupation as managers or housewives, and alcohol consumption. For MS, the significant positive correlates were: lower education level, occupation as service workers or housewives, lower income level, and alcohol consumption. After controlling for age, binary logistic regression analyses suggested the significant risk factors for central obesity were being male (OR = 1.4), married/cohabit (OR = 1.8), longer working hours (OR = 1.5), eating less vegetables (OR = 1.5), and alcohol consumption (OR = 1.8). For MS, only alcohol consumption appeared to be a significant risk factor (OR = 2.3). Multivariate binary logistic regressions also supported that age group and alcohol consumption were significant predictors of MS. To conclude, adopting randomized cluster sampling and IDF criteria, the study revealed a prevalence rate of MS at 14.1%. Alcohol consumption appears to be the strongest risk factor of MS, which however needs further investigation.

Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China

BackgroundAtrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China. MethodsWe measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated. ResultsHigh proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend<0.001). Sensitivity analyses further confirmed these associations. Adding proANP1–98 to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI). ConclusionsContrary to known reduced ANP levels in central obesity, we found that plasma proANP1–98 was positively associated with central obesity, suggesting that elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.

Gender-specific association between tobacco smoking and central obesity among 0.5 million Chinese people: the China Kadoorie Biobank Study.

ObjectivesLifestyle factors are well-known important modifiable risk factors for obesity; the association between tobacco smoking and central obesity, however, is largely unknown in the Chinese population. This study examined the relationship between smoking and central obesity in 0.5 million Chinese adults, a population with a low prevalence of general obesity, but a high prevalence of central obesity.SubjectsA total of 487,527 adults (200,564 males and 286,963 females), aged 30-79 years, were enrolled in the baseline survey of the China Kadoorie Biobank (CKB) Study conducted during 2004-2008. Waist circumference (WC) and WC/height ratio (WHtR) were used as measures of central obesity.ResultsThe prevalence of regular smokers was significantly higher among males (60.6%) than among females (2.2%). The prevalence of central obesity increased with age and BMI levels, with a significant gender difference (females>males). Of note, almost all obese adults (99.4%) were centrally obese regardless of gender. In multivariable regression analyses, adjusting for age, education, physical activity, alcohol use and survey site, regular smoking was inversely associated with BMI in males (standardized regression coefficients, β= -0.093, p<0.001) and females (β= -0.025, p<0.001). Of interest, in the BMI stratification analyses in 18 groups, all βs of regular smoking for WHtR were positive in both genders; the βs showed a significantly greater increasing trend with increasing BMI in males than in females. In the analyses with model adjustment for BMI, the positive associations between regular smoking and WHtR were stronger in males (β= 0.021, p<0.001) than in females (β= 0.008, p<0.001) (p<0.001 for gender difference). WC showed considerably consistent results.ConclusionsThe data indicate that tobacco smoking is an important risk factor for central obesity, but the association is gender-specific and depends on the adjustment for general obesity.

Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors

ObjectiveThis study examined whether a novel indicator of overall childhood adversity, incorporating number of adversities, severity, and chronicity, predicted central obesity beyond contributions of “modifiable” risk factors including psychosocial characteristics and health behaviors in a diverse sample of midlife adults. The study also examined whether the overall adversity score (number of adversities×severity×chronicity) better predicted obesity compared to cumulative adversity (number of adversities), a more traditional assessment of childhood adversity. Materials/Methods210 Black/African Americans and White/European Americans, mean age=45.8; ±3.3years, were studied cross-sectionally. Regression analysis examined overall childhood adversity as a direct, non-modifiable risk factor for central obesity (waist–hip ratio) and body mass index (BMI), with and without adjustment for established adult psychosocial risk factors (education, employment, social functioning) and heath behavior risk factors (smoking, drinking, diet, exercise). ResultsOverall childhood adversity was an independent significant predictor of central obesity, and the relations between psychosocial and health risk factors and central obesity were not significant when overall adversity was in the model. Overall adversity was not a statistically significant predictor of BMI. ConclusionsOverall childhood adversity, incorporating severity and chronicity and cumulative scores, predicts central obesity beyond more contemporaneous risk factors often considered modifiable. This is consistent with early dysregulation of metabolic functioning. Findings can inform practitioners interested in the impact of childhood adversity and personalizing treatment approaches of obesity within high-risk populations. Prevention/intervention research is necessary to discover and address the underlying causes and impact of childhood adversity on metabolic functioning.

Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)

Background The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS). Aim To determine the frequency of M235T and T174M- AGT, I/D- ACE and A1166C- AGTR1 in hypertensive patients with MetS and to evaluate the relationship between these polymorphisms and central obesity and dyslipidemia, respectively. Materials and methods We performed AGT, AGTR1 and ACE genotyping in 56 hypertensive women (24 with MetS) and 71 normotensive women using PCR-RFLP methods and PCR, respectively. Results Hypertensive patients carrying the mutated TT235, MM174 and DD genotypes had an 1.53 (p = 0.56), 1.78 (p = 0.52) and 1.28 (p = 0.78)-fold increased risk to develop MetS. Hypertensive carriers of both mutated TT235 and MM174 or TT235 and D/D or TT235 and CC + AC genotypes had an 8.15 (p = 0.04), 4.83 (p = 0.04) and 10.53 (p = 0.05)-fold increased risk to develop MetS. Hypertensive patients with MetS and TT, D/D or CC genotypes had higher body mass index compared to hypertensive patients without MetS (p ≤ 0.05 for all the genotypes). Hypertensive patients with MetS and TT235, MM174, D/D or CC1166 genotypes had higher triglyceride levels, lower HDL-cholesterol levels and higher waist circumference compared to hypertensive patients without MetS (p ≤ 0.05, except for the association between CC1166 and HDL-cholesterol level). Conclusions The effect of the T174M, I/D and A1166C polymorphisms on MetS may depend on the M235T polymorphism. Among hypertensive subjects with MetS, the presence of TT235, MM174, DD and CC1166 genotypes could be a risk factor for central obesity and dyslipidemia.

Prevalence and Determinants of Central Obesity and Age-Specific Waist: Hip Ratio of People in Five Cities: The Indian Women's Health Study

To study the prevalence of central obesity and age-specific waist:hip ratio of urban women from five Indian cities. Cross-sectional surveys were conducted in 6-12 urban streets in different parts of India using similar methods of sample selection and criteria of diagnosis. We randomly selected 3212 women, aged 25-64 years, from Moradabad (n = 902), Trivandrum (n = 760), Calcutta (n = 365), Nagpur (n = 405), and Bombay (n = 780). Evaluation was by a questionnaire administered by a physician and a dietician, a physical examination, and anthropometric measurements. The overall prevalence of central obesity among the total number of women was 55.0%, with the highest prevalence in Calcutta (62.2%) and the lowest in Bombay (47.4%). Waist:hip ratio was 0.85 +/- 0.13 (mean +/- SD) with the highest ratio for women in Calcutta (0.87 +/- 0.12) and the lowest for women in Moradabad (0.84 +/- 0.16). After pooling of data from all five cities, multivariate logistic regression analysis showed that, regardless of age, body mass index (> 23 kg/m2; odds ratio 1.12), sedentary lifestyle (odds ratio 2.51), and family history of obesity (odds ratio 2.15) were strongly associated with central obesity. Excess intake of fat was weakly associated with central obesity but age was not a risk factor for central obesity, although the prevalence was highest among those aged over 55 years in Moradabad, Calcutta, and Nagpur. The overall prevalence of central obesity among the urban women of India has increased, more so in Calcutta and Trivandrum. Body mass index, sedentary lifestyle, and family history of excess intake of fat were significant risk factors for central obesity.