In order to improve the stability of the slope and prevent the occurrence of landslide disasters, taking the east slope of the first mining area of Zhundong Open-pit Coal Mine as the engineering background, a combination of the 2-Dimensional (2D) limit equilibrium method and 3-Dimensional (3D) numerical simulation is used to optimize the shape of the east slope. By selecting a typical calculation profile based on the Bishop method and the residual thrust method in the 2D rigid body limit equilibrium method, the stability analysis of the profile slope is carried out, and the slope shape of the profile position meeting the requirements of the safety reserve coefficient and stripping ratio is preliminarily designed. Based on the 3D finite element strength reduction method, aiming at the slope shape that does not meet the requirements of safety reserve coefficient and stripping ratio, the width of the transport plate is reasonably changed, and a 3D numerical simulation model of various schemes is established. The influence of different tracking distances and slope angles on slope stability is studied. The 3D stability of the slope under different spatial forms is calculated, and the optimal tracking distance and optimal slope angle are determined. The slope stability and stripping ratio are further optimized. The results show that when the width of the transport plate of the DBS3 section slope is 8 m, it does not meet the requirements of safety reserve coefficient 1.2. When the width of the transport plate is set to 24 m, it meets the requirements of a safety reserve coefficient of 1.2 and an economic stripping ratio of not more than 8.0 m3/t. The 3D numerical simulation results show that the optimal tracking distance on the east side is 50 m, and the optimal slope angle is 35°. After the optimization design of a 2D and 3D slope shape, 2.456 million tons of coal resources were mined, creating a profit of about 21.1268 million yuan. While preventing landslide disasters, the recovery rate of coal resources was further improved.