In this study, computational fluid dynamics was employed to conduct a numerical simulation of the mixing performance and flow characteristics of two highly viscous liquids under laminar flow conditions within a reversed Tesla valve. Scalar transport techniques are employed to analyze the efficiency of liquid–liquid mixing in high-viscosity fluids. The focus of this study is to investigate the optimal mixing behavior between different parameters. Results indicate that an increase in Reynolds number leads to intensified Dean vortices, thereby promoting liquid–liquid mixing efficiency. Additionally, the mixing coefficient shows a negative correlation with Schmidt number (Sc), with a diminishing impact on the mixing coefficient when Sc ≥ 104. This is attributed to the dominance of fluid flow in controlling mixing within the channel at higher Schmidt numbers. Furthermore, this study compares the influence of valve angles (α) and stage numbers (n) on the mixing coefficient under identical Reynolds and Schmidt number conditions. As the number of Tesla valve stages increases, fluid acceleration within the pipeline is enhanced. Moreover, larger valve angles result in increased lengths of the curved section, leading to higher mixing efficiency. Therefore, to enhance mixing efficiency, it is recommended to increase the valve angle and the number of stages in the Tesla valve.